| Project/Area Number |
05403012
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
機能・物性・材料
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| Research Institution | Nagoya University |
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Principal Investigator |
IMAE Toyoko Nagoya University, Dept.of Chem., Associate Prof., 理学部, 助教授 (80101161)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 1995: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1994: ¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 1993: ¥19,700,000 (Direct Cost: ¥19,700,000)
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| Keywords | vesicle / fusion / fractal aggregation / electron microscope / atomic force microscope / Langmuir-Blodgett film / surface force apparatus / small-angle neutron scattering / 分子間力直接測定装置 / 分子間力 / 走査プローブ顕微鏡 |
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| Research Abstract |
The intermolecular interactions which contribute to the fractal aggregation and the fusion process of vesicles in water were investigated for the purpose of making sure of the reaction mechanism of cell segmentation and fusion in an organism. When fatty acid analogs were added in lipid vesicles, the gel-liquid crystal transition were examined. The structure of vesicles constructed by lipid, fatty acid, and the relating amphiphilic molecules was observed by optical and electron microscopes and determined by light scattering and small-angle neutron scattering. These investigation indicates that the character of vesicle membrane depends on the character of additives. The fractal aggregation of crystal islands on Langmuir-Blodgett (LB) membrane of C_<60> fullerene molecules was observed by the atomic force microscope. This is the model investigation of the effect of interparticle interaction on the aggregation process of small particles. The functionality of vesicles is strongly related to the stability of bilayrs. Therefore, amphiphiles with bilayr formation ability were two-dimentionally organized by LB method. The experimental result suggests that the interaction induced by the hydrophilic atmosphere affects to the fractal aggregation and the fusion process of vesicles.
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