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Measurement of mental physical health status utilizing biophysical and psychological methods

Research Project

Project/Area Number 05404025
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Kanehisa  Osaka Univ.Sch.Med., Dept.Hyg.Prev.Med., Professor, 医学部, 教授 (20143414)

Co-Investigator(Kenkyū-buntansha) TAKADAYA Kumiko  Tokyo Univ.Fac, Med., Dept.Matern.Child Health, Assist.Prof., 医学部, 助手 (20125983)
EZOE Satoko  Osaka Univ.Sch.Med., Dept.Hyg.Prev.Med., Assist.Prof., 医学部, 助手 (40232954)
MARUYAMA Soichiro  Osaka Univ.Sch.Med., Dept.Hyg.Prev.Med., Assist.Prof., 医学部, 助手 (70219567)
TAKEUCHI Toru  Osaka Univ.Sch.Med., Dept.Hyg.Prev.Med., Assist.Prof., 医学部, 講師 (00188161)
TAKESHITA Tatsuya  Osaka Univ.Sch.Med., Dept.Hyg.Prev.Med., Assoc.Prof., 医学部, 助教授 (20150310)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥18,100,000 (Direct Cost: ¥18,100,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1994: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1993: ¥10,900,000 (Direct Cost: ¥10,900,000)
Keywordslifestyle / mental health / stress / genetic polymorphism / aldehyde dehydrogenase / active oxygens / NK cell activity / urinary mutagenic activity / 精神的健康度 / 染色体変異 / 活性酸素 / 変異原性 / グルタチオントランスフェラーゼ / IgE / アルデヒド脱水素酸素
Research Abstract

The aim of the present studies was to develop appropriate scientific methods to measure mental and physical health status in a general population. The subjects were healthy Japanese workers in a medium-sizad plant. As for relevant environmental factors, we got information on the subjects' lifestyles such as smoking, alcohol drinking, exercise, and working hours. We utilized various established questionnaires to evaluate mental health status, including General Health Questionnaire (GHQ), Life event scale, Daily hassles scale, and Job strain scale. We also used various experimental methods to assess biophysical health atatus including NK cell activity, total IgE level, chromosome alterations in peripheral lymphocytes, DNA damage caused by active oxygens in leukocytes, and urinary mutagenic activity. Some outstanding genetic polymorphisms such as those in low Km aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH2) genes were assessed using polymerase chain reaction (PCR) coupled with digestions by resriction enzymes. A significant association between NK cell activity and job strains was suggested. Urinary mutagenic activity was significantly correlated with smoking and other lifestyles. We established the method to accurately measure 8-hydroxy-deoxyguanosine (8-OHdG) levels, typical DNA damage caused by active oxygens, using an oxygen-free DNA extracting system. Habitual alcohol drinkers lacking the ALDH2 activity had significantly higher chromosome damage levels than nonhabitual drinkers or habitual drinkers with active ALDH2. We also established the method to detect the polymorphism in glutathione-s-transferase mu type (GSTM1).

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (90 results)

All Other

All Publications (90 results)

  • [Publications] Morimoto,K.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity" Int.Arch.Occup.Environ.Health. 65. S37-S41 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita,T.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa,T.: "Effect of lifestyle on levels of specific IgE antibodies." Allergy. 48. 177-182 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Increased formation of 8-hydroxydeoxy-guanosine,an oxidative DNA damage,in lymphoblasts from Fanconi′s anemia patients due to possible catalase deficiency." Carcinogenesis. 14. 115-1120 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Spin trapping of superoxide released by opsonized asbestos from human promyelocytic leukemia cell line,HL60." Biochem.Biophys.Res.Com.194. 57-64 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita,T.: "Elevated chromosome aberration frequency after X-ray exposure in cultured fibroblasts derived from patients with porokeratosis." Cancer Genet.Cytogenet.73. 161-164 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita,T.: "Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population." Hum.Genet.94. 217-223 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Crocidolite asbestos increased 8-hydroxy-guanosine levels in cellular DNA of a human promyelocytic leukemia cell line,HL60" Carcinogenesis. 15. 635-639 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Evaluation of 8-hydroxydeoxyguanosine,a typical oxidative DNA damage,in human leukocytes." Carcinogenesis. 15. 1519-1523 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Establishment of a human system that generates O2-and induces 8-hydroxydeoxyguanosine,typical of oxidative DNA damage,by a tumor promotor." Cancer Res.54. 5837-5840 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Calyculin A,a non-phorbol ester type tumor promotor,induced oxidative DNA damagein stimulated human neutrophil-like cells." Biochem.Biophys.Res.Commun.205. 1803-1807 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa,T.: "Linkage between severe atopy and chromosome 11q13 in Japanese families." Clin.Genet.46. 228-232 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ezoe,S.: "Behavioral lifestyle and mental health status among Japanese industril workers" Prev.Med.23. 98-105 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ezoe,S.: "Quantitative assessment of stressors and stress reaction: A review." Jpn.J.Ind.Health. 36. 397-405 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Zhu,J.H.,: "Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes." Cancer Res.55. 1221-1223 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa,T.: "Association between FcεβRl and atopic disorder in a Japanese population." Lancet. 347. 394-395 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita,T.: "The contribution of polymorphism in the alcohol dehydrogenase β subunit to alcohol sensitivity in a Japanese population." Hum.Genet.97. 409-413 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakajima,M.: "Determination of 8-hydroxyguanosine in human cells under oxygen-free conditions." Garcinogenesis. 17. 787-791 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Inoue,C: "Cigarette smokingis associated with the reduction of lymphokine-activated killer celi and natural killer cell activities." Environ.Health Pre.Med.1. 14-19 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mao,X-Q: "Association between genetic variants of mast-cell chymase and eczema." Lancet. 348. 581-583 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi,T.: "Relationship between the intracellular reactive oxygen species and the induction of oxidative DNA damage in human neutrophil-like cells." Carcinogenesis. 17. 1543-1548 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morimoto,K.: "Low Km Aldehyde Dehydrogenase (ALDH2) polymorphism,Alcohol-drinking behavior,and chromosome alterationa in peripheral lymphocytes." Env.Health Perspect.104. 563-567 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mure,K.: "Urinary mutagens and lifestyle factors." Prev.Med.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maruyama,S.: "Effects of long working hours on life-styles,stress and quality of life in the Japanese intermediate managers." Scan.Work.Environ Health. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morimoto,K.: "In: Obe,G.and Natarajan,A.T.(eds.): Chromosomal aberrations.Basic and applied aspects." Does he genetic deficiency in ALDH2 determine the alcohol-drinking behavior and the alcohol induction of chromosome alterations in peripheral lymphocytes?, 293-305 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 森本兼曩: "高度技術社会の展望(竹内 啓編)" 丸善(in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morimoto, K., Takeshita, T., Takeuchi, T., Maruyama, S., Ezoe, S., Mure, K.and Inoue, C: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity" Int.Arch.Occup.Environ.Health. 65. S37-S41 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, T., Morimoto, K., Mao, X., Hashimoto, T.and Furuyama, J.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japaneseworkers." Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sandford, A.J., Shirakawa, T., Moffatt, M.F., Daniels, S.E., Ra, C., Faux, J.A., Yound, R.P., Nakamura, Y., Lathrop, G.M., Cookson, W.O.C.M., and Hopkin, J.M: "Localisation of atopy and beta subuit of high-affinity IgE receptor (FcepsilonbetaRI) on chromosome 11q" Lancet. 341. 332-334 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T.and Morimoto, K: "Effect of lifestyle on levels of specific IgE antibodies." Allergy. 48. 177-182 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T.and Morimoto, K: "Increased formation of 8-hydroxydeoxy-uyanosine, an oxidative DNA damage, in lymphoblasts from Fanconi's anemia patients due to possible catalase deficiency." Carcinogenesis. 14. 1115-1120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Morimoto, K., Kosaka, H.and Shiga, T: "Spintrapping of superoxide released by opsonized asbestos from human promyelocytic leukemia cell line, HL60" Biochem.Biophys.Res.Com. 194. 57-64 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ono, Y., Ezoe, S., Sueoka, R., Hirashima, N., Shirahase, J., Morimoto, K., Okonogi, K.and Asai, M.: "Comparative study of personality disorders diagnosed by DSM-III-R and ICD-10" Jpn.J.Psychiat.Neurol. 47. 947-948 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tarumi, K., Hagihara, A.and Morimoto, K: "An inquiry into the relationship between job strain and blood pressure in male whitecollar workers." Jpn.J.Ind.Health. 35. 269-276 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morimoto, K., Miura, K., Takeshita, T., Mure, K., and Inoue, C: "Does the genetic deficiency in ALDH2 determine the alcohol drinking behavior and the alcohol induction of chromosome alterations in peripheral lymphocytes?" In : Obe, G.and Natarajan, A.T.(eds.) : Chromosomal aberrations.Basic and applied aspects Springer-Verlag, Berlin, Heidelberg. 293-305 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, T., Higurashi, M., Ariizumi-Shibusawa, C., Shimizu, K., Iijima, S., Yamagata, Z., Asaka, A.Morimoto, K., Ishibashi, Y.and Otsuka F.: "Elevated chromosome aberration frequency after X-ray exposure in cultured fibroblasts derived from patients with porokeratosis." Cancer Genet.Cytogenet. 73. 161-164 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, T., Morimoto, k., Mao X.Q., Hashimoto, T., Furuyama, J: "Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population." Hum.Genet. 94. 217-223 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Morimoto, K: "Crocidolite asbestos increased 8-hydroxy-guanosine levels in cellular DNA of a human promyelocytic leukemia cell line, HL60." Carcinogenesis. 15. 635-639 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Nakajima, M., Ohta, Y., Mure, K., Takeshita, t.and Morimoto, K: "Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes." Carcinogenesis. 15. 1519-1523 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Nakajima, M.and Morimoto, K: "Establishment of a human system that generates O2-and induces 8-hydroxydeoxyguanosine, typical of oxidative DNA damage, by a tumor promotor." Cancer Res. 54. 5837-5840 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Nakajima, M.and Morimoto, K: "Calyculin A,a non-phorbol ester type tumor promotor, induced oxidative DNA damage in stimulated human neutrophil-like cells." Biochem.Biophys.Res.Commun. 205. 1803-1807 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T., Hashimoto, T., Furuyama, J., Morimoto, K: "Linkage between severe atopy and chromosome 11q13 in Japanese families." Clin.Genet. 46. 228-232 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ezoe, S.and Morimoto, K: "Behavioral lifestyle and mental health status among Japanese industrial workers" Prev.Med. 23. 98-105 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ezoe, S.and Morimoto, K: "Quantitative assessment of stressors and stress reaction : A review" Jpn.J.Ind.Health. 36. 397-405 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mandai, T., Ohashi, K., Ishii, K., Ono, M., Kishi, K., Hashimoto Y., Minakata, T., Takagi, J., Fujita, H., Egoh, Y., TSUCHIYA,K., Saeki, H., Takashima, S., Asahi, T., Mandai, K., Adachi, s., maruyama, S.and Morimoto, K.: "Quality of life in patients with Haemodialysis, coronary artery bypass craft (CABG) surgery and mammary cancer." Qualiy of Life Research. 1. 85-86 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mure, K.and Morimoto, K.: "Genotoxic potentials of lifestyles assessed by urinary mutagenicity." J.Osaka Univ. 43. 9-15 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tarumi, K., Hagihara, A.and Morimoto, K.: "An investigation of the effects of lifestyle on care-seeking behavior using data from health insurance claims." Jpn.J.Hyg. 49. 984-997 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Zhu, J.H., Takeshita, T., Kitagawa, I.and Morimoto, K: "Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes." Cancer Res. 55. 1221-1223 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T., Mao, X-O., Sasaki, S., Kawai, M., Morimoto, K.and Hopkin, J.M: "Association between FcE<square root> RIE* and atopic disorder in a Japanese population." Lancet. 347. 394-395 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, K., Mao, X-Q.and Morimoto, K: "The contribution of polymorphism in the alcohol dehydrogenase E*subunit to alcohol sensitivity in a Japanese population." Hum.Genet. 97. 409-413 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, T.and Morimoto, K: "Effects of genetic polymorphisms in alcohol-merabolizing enzymes on alcohol hypersensitivity and alcohol-related health prblems in orientals" Environmental Health and Preventive Medicine. 1. 1-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakajima, M., Takeuchi, T.and Morimoto, K: "Determination of 8-hydroxyguanosine in human cells under oxygen-free conditions." Carcinogenesis. 17. 787-791 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Inoue, C,Takeshita, T., Kondou, H.and Morimoto, K: "Cigarette smoking is associated with the reduction of lymphokine-activated killer cell and natural killer cell activities." Environ.Health Pre.Med. 1. 14-19 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mao, X-Q., Shirakawa, T., Yoshikawa, T., Yoshikawa, K., Kawa, M., Sasaki, S., Enomoto, T., Hashimoto, T., Furuyama, J., Hopkin, J.M., and Morimoto, K: "Association between genetic variants of mast-cell chymase and eczema." Lancet. 348. 581-583 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeuchi, T., Nakajima, M.and Morimoto, K: "Relationship between the intracellular reactive oxygen species and the induction of oxidative DNA damage in human neutrophil-like cells." Carcinogenesis. 17. 1543-1548 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mure, K., Takeshita, T.and Morimoto, K: "Categorization of micronuclei by size and measurement of each ratio in cytokinesis-block and conventional cultures of human lymphocytes exposed to mitomycin C and colchicine." Environ.Health Pre.Med. 1. 93-99 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ogura, H., Takeuchi, T.and Morimoto, K: "A comparison of the 8-hydroxydeoxyguanosine, chromosome aberrations and micronucleus techniques for the assessment of the genotoxicity of mercury compounds in human blood lymphocytes." Mutation Res. 340. 175-182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morimoto, K.and Takeshita, T: "Low Km Aldehyde Dehydrogenase (ALDH2) polymorphism, Alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes." Env.Health Perspect. 104 (Suppl.3). 563-567

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T.and Morimoto, K: "Brief recersible bronchospasm due to bichromate exposure." Arch.Environ.Health. 51. 221-226 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshita, T.and Morimoto, K: "Health promotion activities in Japan." J.Epidemiol. 6. S165-S168 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, H.and Morimoto, K: "Effects of mental arithmetic stress on blood cell counts and the immune system." Environ.Health Prev.Med. 1. 76-79 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mure, K., Takeshita, T., Takeuchi, T.and Morimoto, K: "Urinary mutagens and lifestyle factors." Prev.Med. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T., Hayakawa, K., Shimizu, T.and Morimoto, K: "Unhealthy lifestyle promotes allergic disorder as well as immuno-suppression modulated by IgE." J.Clin.Epidemiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mao, X-Q., Morimoto, K., Shirakawa, T., Hopkin, J.M.et al: "Association between serotonin type 2 receptor (HTR2) and bronchial asthma in humans." J.Med.Genet. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maruyama, S.and Morimoto, K: "Effects of long working hours on lifestyles, stress and quality of life in the Japanese intermediate managers." Scan.J.Work.Environ Health. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maruyama, S., Inoue, C., Fukuda, S.and Morimoto, K: "Assessing stress reactions in adults after the Great Hanshin Earthquake." Physiological Anthropology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shirakawa, T., Morimoto, K., Sasaki, S.and Kuroda, E: "Effect of maternal lifestyle on cord blood IgE factor." Eur.J.Epidemiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 森本兼曩: "ストレス反応の意味するもの-遺伝子変異からJob.satisfactionまで-" 産業ストレス研究. 3. 12-24 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Zhu,J.H.: "Suppression of the formation of sister chromatid exchanges by low conccntrations of ginsenoside Rh2 in buman blood lymphocytes" Cancer Research. 55. 1221-1223 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 丸山総一郎: "中間管理職のメンタルヘルスに関する予防医学的研究(第2報):部課長における長時間労働のライフスタイル,ストレス及び労働生活満足度への影響" 日本衛生学雑誌. 50. 849-860 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakajima,M.: "Determination of 8-hydroxyguanosine in human cells under oxygen-free conditions" Carcinogenesis. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inoue,C.: "Cigarette smoking is associated with the reduction of lymphokineactivated killer cell and natural killer cell activities" Environ Health Prev.Med.1(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takeshita,T.: "The contribution of polymorphism in the alcohol dehydrogenase subunit to alcohol sensitivity in a Japanese population" Human Genetics. 97(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 森本兼曩: "高度技術社会の展望(竹内 啓編)" 丸善.(in press), (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 森本兼曩: "ライフスタイル環境と健康度との関連性にかかわる予防医学研究" Deutsche Medizinische Wochenschrift 日本語翻訳版. 16. 50-66 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森本兼曩: "ライフスタイルとアレルギー反応感受性" 治療. 76. 2766-2768 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森本兼曩: "ライフスタイルと免疫学的防御機構" 日本医事新報. (3684). 2766-2768 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takeuchi T.: "Establishment of a human system that generates 02-and induces 8-hydroxydeoxyguanosine,typical of oxidative DNA damage,byk a tumor" Cancer Research. 54. 5837-5840 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takeshita T.: "Characteriztion of the three genotypes of low Km aldehyde dehydrogenase in a Japan population" Human Genetics. 94. 217-223 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ezoe,S.: "Behavioral lifestyle and mental health status of Japanese factory workers" Preventive Medicine. 23. 98-105 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Morimoto,K.: "Chromosomal aberrations.Basic and applied aspects." Springer-Verlag, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森本兼曩: "労働衛生ハンドブック補遣" 労働科学研究所, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Morimoto,K.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity." Int.Arch.Occup.Env.Health. 65. 37-41 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeshita,T.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shirakawa,T.: "Effect of lifestyle on levels of speciffic IgE anti-bodies." Allergy. 48. 177-182 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeuchi,T.: "Increased formation of 8-hydroxydeoxyguanosine,an oxidative DNA damage,in lymphoblasts from Fanconi's anemia patients due to possible catalase deficiency" Carcinogenesis. 14. 1115-1120 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeuchi,T.: "Spin trapping of superoxide released by opsonized asbestos from human promyelocytic leukemia cell line." HL60.Biochem:Biophys.Res.Com.194. 57-64 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ezoe,S.: "Behavioral life-style and mental health status of Japanese factory worker" Prev.Med.(in press). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Obe,G.: "Chromosomal aberrations,Basic and applied aspects.(in press)(分担)" Springer-Verlag,Berlin, (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 志賀 健: "環境と健康" HBJ出版局, (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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