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Rapid Screening for drugs and poisons in emergency medical care and clinical forensic toxicology.

Research Project

Project/Area Number 05404027
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionKanazawa University

Principal Investigator

ICHIMURA Fujio  Kanazawa Univ., Hospital Pharmact, Professor, 医学部・附属病院, 教授 (40143911)

Co-Investigator(Kenkyū-buntansha) TAKAYASU Tatsunori  Kanazawa Univ., Faculty of Medicine, Legal Medicine, Assoc. Professor, 医学部, 助教授 (80154912)
YOSHITA Yutaka  Kanazawa Univ., University Hospital, Intensive Care Unit, Instructor, 医学部・附属病院, 助手 (30201023)
OHSIMA Tohru  Kanazawa Univ., Faculty of Medicine, Legal Medicine, Professor, 医学部, 教授 (40183024)
HASHIMOTO Takuma  Kanazawa Univ., Faculty of Medicine, Laboratory Medicine, Professor, 医学部, 教授 (10124710)
NAGANO Taizo  National Institute of Police Science, Head, 所長 (20073679)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥33,200,000 (Direct Cost: ¥33,200,000)
Fiscal Year 1995: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1994: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1993: ¥23,800,000 (Direct Cost: ¥23,800,000)
KeywordsEmergency Medical Care / Pharmacokinetics / Quality Control / Clinical Forensic Medicine / Forensic Toxicology / Rapid Screening System / REMEDi-HS System / 迅速スクリーニングツシステム / REMEDi‐HSシステム / スクリーニングシステム / 薬毒物動態
Research Abstract

The present research is composed of basic and practical studies. Furthermore, the basic study is divided into the following three subjects : 1. pharmacokinetic study, 2. study on quality control and 3. development of new analytical methods for drugs and poisons.
1. The mechanism of interindividual differences on drug action and toxicity was investigated by using physiological pharmacokinetic analyzes. Systematic approach to individualizing the dose was established. In order to predict the change during regeneration and recovery from hepatic damage, an altered AST was found to be a good index of metabolic function. Quantitative relationship between structure and peritoneal membrane transport for acidic drugs were also established. The potential effects of chemical drugs on the effects of biotechnological drugs were discovered.
2. IRMA,EIA and CLEIA methods were studied for LH,FSH,etc. in the plasma in a hospital laboratory. Based on the results obtained, the importance of quality control … More was concretely demonstrated.
3. (1) An analytical method for benzodiazepines was newly developed using supercritical fluid extraction and supercritical fluid chromatography. (2) The availability of rapid quantitative analytical system (REMEDi-HS) was basically examined. Practically, REMEDi-HS system was applied to the samples in emergency medical care and medico-legal autopsy cases, and the advantages and disadvantages of the system were discussed. (3) Pulse heating method was applied to the analysis of volatile substances including widely used anesthetics. (4) Even in the formalin-fixed tissues, methamphetamine, volatile substances, diazepam and chlorpromazine were determined by GC-MS.
In emergency medical care and medico-legal autopsy cases, blood and urine were analyzed by the screening system above. Among the emergency care cases, there was a case with successful diagnosis as an acute bromisovalum intoxication by the system, and the information much contributed to the specific therapy of the patient. In the autopsy cases, there were cases in which methamphetamine and barbital were determined in the lethal and therapeutic level, respectively. In such cases, drug analysis gives useful information to assess objective evidence on dead bodies. Less

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (114 results)

All Other

All Publications (114 results)

  • [Publications] 中島恵美 他: "ラジオレセプターアッセイによる中枢神経作用薬の微量定量法の確立とラットにおける体内動態解析への応用" Jpn.J.Hosp.Pharm.19. 111-118 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 中島恵美 他: "グラフ法を用いた剤形変更に伴うフェニトインの個別投与設計" TDM研究. 10. 159-165 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 中島恵美 他: "定常状態における1点の血獎中濃度を利用したグラフ法によるフェニトインの投与設計-体系的方法の確立-" TDM研究. 10. 231-232 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima et al.: "Sudden death of a young male patient of manic-depressive psychosis under medical treatment with tricyclic antidepressant and carbamazepine." Act.Crim.Japon.59. 165-169 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima et al.: "An autopsy case of pathological intracerebral bleeding suspected of death due to fire-an example of CO-oximeter application to forensic practice" Act.Crim.Japon.59. 189-194 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高安達典 他: "7種の薬物が検出された一中毒死例" 日法医誌. 47. 63-71 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西上 潤 他: "TOXI-LABスクリーニングの法医中毒学的応用.-剖検及び救急患者試料を用いて-." 日法医誌. 47. 372-379 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西部万千子 他: "IRMA法およびEIA法によるLH,FSHの測定値の比較" 医学検査. 43. 909-914 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Hashimoto et al.: "A case of Graves's disease with falsely high THS value due to human anti-murine antibody (HAMA)." Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects,Eds,A.K.Cambell,L.J.Kricka and P.E.Stanley.285-288 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本啄磨 他: "蛍光イムノアッセイ(FIA)" 検査と技術. 22. 61-66 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本啄磨 他: "ホルモン測定法の最前線" 臨床検査. 38. 49-57 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Shibata et al.: "Extensive chemical burns from toluene." Am.J.Emergency Med.12. 353-355 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大島 徹 他: "薬毒物分析が事件の全容解明に寄与した4司法解剖例" 中毒研究. 7. 156-159 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大島 徹 他: "致死的な血中アルコール濃度を示した1焼死例" 法医学の実際と研究. 38. 205-208 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Toxicological analysis for drugs and poisons using the formalin-fixed organ tissues-1.Methamphetamine." Jpn.J.Legal Med.48. 33-37 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Toxicological analysis for drugs and poisons in formalin-fixed organ tissues.2.Volatile substances." Int.J.Legal Med.107. 7-12 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami et al.: "Toxicological analysis of the psychotropic drugs chlorpromazine and diazepam using chemically fixed organ tissues." Int.J.Legal Med.107. 165-170 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami et al.: "A suicidal case due to inhalation of gasoline vapor in the trunk of a car." Jpn.J.Forensic Toxicol.12. 33-39 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西上 潤 他: "水中死体からの薬毒物スクリーニング-4検出例について-" 法医学の実際と研究. 37. 133-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Systematic approach to a dosage regimen for phenytoin based on one-point,steady-state plasma concentration." Ther.Drug Monit.17. 12-18 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Age-related changes in pharmacokinetic parameters of phenytoin after liver resection in rats." Pharm.Res.12. 1530-1534 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide." J.Pharm.Sci.84. 1205-1209 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Human MCAF gene transfer enhances the metastatic capacity of a mouse cachectic adenocarcinoma cell line in vivo." Pharm.Res.12. 1598-1604 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs." Drug Metab.Dispos.23. 1220-1224 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西部万千子 他: "ルミパス1200によるCA125測定の検討" 日本臨床検査自動化学会会誌. 20. 803-806 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本啄磨: "内分泌検査のQuick Return Service" 臨床病理. 43. 1034-1037 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本啄磨: "甲状腺機能検査法の臨床的評価" 日本医事新報. 3734. 21-25 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Tomoda et al.: "Variation of urinary pH and bicarbonate concentrations of students in metropolitan and rural areas of Japan." Arch.Environ.Health.50. 457-461 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Analysis of several volatile anesthetics in biological samples by pulse heating method." Proc.13th meeting Internatl.Assoc.Forensic Sciences. 5. 146-150 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Screening and determination of methamphetamine and amphetamine in the blood,urine and stomach contents in emergency medical care and autopsy caes." J.Clin.Forensic Med.2. 25-33 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Saito et al.: "Determlnation of the volatile anesthetics halothane,enflurane,isoflurane and sevoflurane in bioiogical specimens by pulse-heating GC-MS." J.Anal.Toxicol.19. 15-119 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Screening of volatlle substances and determlnation of toluene (a thinner component) in the blood and urine in emergency medical and autopsy cases by pulse heating method." J.Clin.Forensic Med.2. 65-72 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Postmortem degradation of administered ethanol-d6 and production of endogenous ethanol-Experimental studies using rats and rabbits." Forensic Sci.Int.76. 129-140 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu et al.: "Experimental studies on postmortem diffusion of ethanol-d6 using rats." Forensic Sci.Int.76. 179-188 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大辻雅彦 他: "REMEDi-HSシステムを用いた薬毒物分析" 法中毒. 13. 39-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高安達典 他: "化学固定臓器からの薬毒物分析" 日本医事新報. 3710. 128-129 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuji et al.: "Screening of antihistamine agents (diphenhydramine) with blood and urine samples by REMEDi-HS System." Proc.of the 13th International Conference on Alcohol,Drugs and Traffic Safety. 1. 321-236 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Shibata et al.: "Severe hyponatremia causedby cement ingestion during carbamazepine therapy." Am.J.Emergency Med.13. 245-247 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima et al.: "A case of death due to outbreak of fire during thinner abuse." Jpn.J.Legal Med.50. 33-36 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Morishita et al.: "Hypercoagulability and high lipoprotein (a) levels in patients with type II diabetes mellitus." Atherosclerosis. 120. 7-14 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Kinetic evidence for facilitated peritoneal transport of benzoic acid in rats." J.Pharm.Pharmacol.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuji et al.: "The use of REMEDi-HS in emergency toxicology for a rapid estimate of drug concentrations in urine,serum and gastric samples." J.Forensic Sci.41(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本啄磨: "RIAとIRMA免疫実験操作法(右田俊介,紺田進,本庶佑,濱岡利之編)" 南江堂, 298-309 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, M.Takeda, J.Ishizaki, K.Yokogawa: "R.Matsushita and F.Ichimura. Development of radioreceptor for microdetermination of drug acting on the central nervous system and its application to a pharmacokinetics in rats." Jpn. J.Hosp. Pharm.19(2). 111-118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, H.Kido, R.Matsushita, N.Kanada, F.Ichimura and N.Yamaguchi: "Graphic estimation of individual phenytoin dosage for the change of dosage forms." Jpn. J.Ther. Drug Monit.10(2). 159-165 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima, T.Takayasu and T.Nagano: "Sudden death of a young male patient of manic-depressive psychosis under medical treatment with tricyclic antidepressant and carbamazepine." Act. Crim. Japon.59(4). 165-169 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima, T.Takayasu and T.Nagano: "An autopsy case of pathological intracerebral bleeding suspected of death due to fire-an example of CO-oximeter application to forensic practice." Act. Crim. Japon.59(5). 189-194 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu, J.Nishigami, T.Ohshima, Z.Lin, T.Kondo, T.Nakaya, T.Sawaguchi and T.Nagano: "A fatal case due to intoxication with seven drugs detected by GC-MS and TDx methods." Jpn. J.Legal Med.47(1). 63-71 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami, T.Ohshima, T.Takayasu, T.Kondo, Z.Lin and T.Nagano: "Forensic toxicological application of TOXI-LAB screening for biological specimens in autopsy cases and emergency cares." Jpn. J.Legal Med.47(5). 372-379 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Nishibu, M.Matsubara, T.Hashimoto, K.Ohba and Y.Senda: "Determination of LH and FSH by IRMA and EIA methods." Jpn. J.Med. Technol.43(5). 909-914 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Hashimoto, S.Azuma, M.Nishibu, S.Itoh and S.Tsukamoto: "A case of Graves' disease with falsely high TSH value due to human anti-murine antibody (HAMA)." Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects, John Wiley and Sons Ltd.285-288 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Shibata, Y.Yoshita and H.Matsumoto: "Extensive chemical burns from toluene." Am. J.Emegency Med.12(3). 353-355 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima, T.Takayasu, J.Nishigami, T.Magano: "Four medico-legal autopsy cases with the analysis of contribution of drug and poison to the cause of death." Jpn. J.Toxicol.7. 156-159 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohshima, T.Kondo, T.Minamino and J.Nishigami: "A case of death due to fire with blood alcohol concentration of lethal level." Res. Pract. Forens. Med.38. 205-208 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu, T.Ohshima, J.Nishigami, T.Kondo, Z.Lin, M.Ohtsuji and T.Nagano: "Toxicological analysis for drugs and poisons using the formalin-fixed organ tissues-1. Methamphetamine." Jpn. J.Legal Med.48(1). 33-37 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu, K.Saito, J.Nishigami, T.Ohshima and T.Nagano: "Toxicological analysis of drugs and poisons in formalin-fixed organ tissues. 2. Volatile substances." Int. J.Legal Med.107(1). 7-12 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami, T.Takayasu and T.Ohshima: "Toxicological analysis of the psychotropic drugs chlorpromazine and diazepam using chemically fixed organ tissues." Int. J.Legal Med.107(4). 165-170 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami, T.Ohshima, T.Kondo and M.Ohtsuji: "A suicidal case due to inhalation of gasoline vapor in the trunk of a car." Jpn. J.Forensic Toxicol.12(1). 33-39 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.Nishigami, T.Ohshima, T.Kondo, T.Takayasu, M.Ohtsuji, Z.Lin and T.Minamino: "Forensic Toxicological screening on immersed bodies. -Four positive cases of drug detection-." Res. Pract. Forens. Med.37. 133-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, R.Matsushita, H.Kido, M.Nakamura, M.Asahi and F.Ichimura: "Systematic approach to a dosage regimen for phenytoin based on one-point, steady-state plasma concentration." Ther. Drug Monit.17(1). 12-18 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, R.Matsushita, Y.Iida, T.Ohshima and F.Ichimura: "Age-related changes in pharmacokinetic parameters of phenytoin after liver resection in rats." Pharm. Res.12(10). 1530-1534 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, R.Matsushita, H.Negishi, M.Nomura, S.Harada, H.Yamamoto, K.Miyamoto and F.Ichimura: "Reversal of drug sensitivity in MDR subline of P388 leuklemia by gene-targeted antisense oligonucleotide." J.Pharm. Sci.84(10). 1205-1209 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, N.Mukaida, Y.Kubota, K.Kuno, K.Yasumoto, F.Ichimura, I.Nakanishi, M.Miyasaka and K.Matsushima: "Human MCAF gene transfer enhances the metastatic capacity of a mouse cachectic adenocarcinoma cell line in vivo." Pharm. Res.12(11). 1598-1604 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima, R.Matsushita, T.Ohshima, A.Tsuji and F.Icshimura: "Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs." Drug Metab. Dispos.23(11). 1220-1224 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] M.Nishibu, Y.Senda, K.Kawai and T.Hashimoto: "Evaluation of LUMIPULSE 1200 on the determination of serum CA125." JJCLA. 20(6). 803-806 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Hashimoto: "Quick return service in endocrinological tests." Jpn. J.Clin. Pathol.43(10). 1034-1037 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] A.Tomoda, S.Yamanaka, H.Kawai, H.Itoh, M.Katsumata, M.Minami, T.Hashimoto, H.Tanii and K.Hashimoto: "Variation of urinary pH and bicarbonate concentrations of students in metropolitan and rural areas of Japan." Arch. Environ. Health. 50(6). 457-461 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] T.Takayasu, T.Ohshima, J.Nishigami, K.Saito, T.Nakaya, T.Kondo and T.Nagano: "Analysis of several volatile anesthetics in biological samples by pulse heating method." Proc. 13th Meeting Internatl. Assoc. Forensic Sciences. Vol.5. 146-150 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] T.Takayasu, T.Ohshima, J.Nishigami, T.Kondo, and T.Nagano: "Screening and determination of methamphetamine and amphetamine in the blood, urine and stomach contents in emergency medical care and autopsy cases." J.Clin. Forensic Med.2(1). 25-33 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Saito, T.Takayasu, J.Nishigami, T.Kondo, M.Ohtsuji, Z.Lin and T.Ohshima: "Determination of the volatile anesthetics halothane, enflurane, isoflurane and sevofluranein biological specimens by pulse-heating GC-MS." J.Anal. Toxicol.19(2). 115-119 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu, T.Ohshima, J.Nishigami, M.Ohtsuji, T.Kondo and T.Nagano: "Screening of volatile substances and determination of toluene (a thinner component) in the blood and urine in emergency medical and autopsy cases by pulse heating method." J.Cllin. Forensic Med.2(2). 65-72 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Takayasu, T.Ohshima, N.Tanaka, H.Maeda, T.Kondo, J.Nishigami and T.Nagano: "Postmortem degradation of administered ethanol-d6 and production of endogenous ethanol-Experimental studies using rats and rabbits." Forensic Sci. Int.76(2). 129-140 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] T.Takayasu, T,Ohshima, N.Tanaka, H.Maeda, T.Kondo, J.Nishigami, M.Ohtsuji and T.Nagano: "Experimental studies on postmortem diffusion of ethanol-d6 using rats." Forensic Sci. Int.76(3). 179-188 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuji, T.Kondo, J.Nishigami, T.Takayasu, Y.Yoshita and T.Ohshima: "Analysis for drugs and poisons by the REMEDi-HS system." Jpn. J.Forensic Toxicol.13(1). 39-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuji, T.Ohshima, T.Takayasu, J.Nishigami, T.Kondo, Z.Lin and T.Minamino: "Screening of antihistamine agents (diphenhydramine) with blood and urine samples by REMEDi-HS System." Proc. of the 13th International Conference on Alcohol, Drugs and Traffic Safety. Vol1. 321-326 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Shibata, S.Tsugawa, M.Ohtsuji, T.Kondo and T.Ohshima: "Severe hyponatremia caused by cement ingestion during carbamazepine therapy." Am. J.Emergency Med.13. 245-247 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Ohshima, T.Kondo, M.Ohtsuji, T.Minamino and J.Nishigami: "A case of death due to outbreak of fire during thinner abuse." Jpn. J.Legal Med.50(1). 33-36 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Morishita, H.Asakura, H.Jokaji, M.Saito, C.Uotani, I.Kumabashiri, M.Yamazaki, K.Aoshima, T.Hashimoto and T.Matsuda: "Hypercoagulability and high lipoprotein (a) levels in patients with type II diabetes mellitus." Atherosclerosis. 120. 7-14 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] E.Nakashima, R.Matsushita, N.Kanada and F.Ichimura: "Kinetic evidence for facilitated peritoneal transport of benzoic acid in rats." J.Pharm. Pharmacol.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] M.Ohtsuji, J.Lai, S.R.Binder, T.Kondo, T.Takayasu and T.Ohshima: "The use of REMEDi HS in emergency toxicology for a rapid estimate of drug concentrations in urine, serum and gastric samples." J.Forensic Sci.41 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E.Nakashima et al.: "Systematic approach to a dosage regimen for phenytoin based on one‐point, steady‐state plasma concentration." Ther. Drug Monit.17. 12-18 (1995)

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  • [Publications] E.Nakashima et al.: "Age‐related changes in pharmacokinetic parameters of phenytoin after liver resection in rats." Pharm. Res.12. 1530-1534 (1995)

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  • [Publications] E.Nakashima et al.: "Reversal of drug sensitivity in MDR subline of P388 leukemia by gene‐targeted antisense oligonucleotide." J.Pharm. Sci.84. 1205-1209 (1995)

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  • [Publications] E.Nakashima et al.: "Human MCAF gene transfer enhances the metastatic capacity of a mouse cachectic adenocarcinoma cell line in vivo." Pharm. Res.12. 1598-1604 (1995)

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  • [Publications] E.Nakashima et al.: "Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs." Drug Metab. Dispos.23. 1220-1224 (1995)

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  • [Publications] 西部万千子 他: "ルミパス1200によるCA125測定の検討" 日本臨床検査自動化学会会誌. 20. 803-806 (1995)

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  • [Publications] 橋本琢磨: "内分泌検査のQuick Return Service" 臨床病理. 43. 1034-1037 (1995)

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  • [Publications] 橋本琢磨: "甲状腺機能検査法の臨床的評価" 日本医事新報. 3734. 21-25 (1995)

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  • [Publications] A.Tomoda et al.: "Variation of urinary pH and bicarbonate conentrations of students in metropolitan and rural areas of Japan." Arch. Environ. Health.50. 457-461 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takayasu et al.: "Analysis of several voiatile anesthetics in biological samples by pulse heating method." Proc. 13th meeting Internatl. Assoc. Forensic Sciences. 5. 146-150 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takayasu et al.: "Screening and determination of methamphetamine and amphetamine in the blood, urine and stomach contents in emergency medical care and autopsy cases." J.Clin. Forensic Med.2. 25-33 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Saito et al.: "Determination of the volatile anesthetics halothane, enflurane, isoflurane and sevoflurane in biological specimens by pulse‐heating GC‐MS." J.Anal. Toxicol.19. 115-119 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takayasu et al.: "Screening of volatile substances and determination of toluene (a thinner component)in the blood and urine in emergency medical and autopsy cases by pulse heating method." J.Clin. Forensic Med.2. 65-72 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takayasu et al.: "Postmortem degradation of administered ethanol‐d6 and production of endogenous ethanol‐Experimental studies using rats and rabbits." Forensic Sci. Int.76. 129-140 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takayasu et al.: "Experimental studies on postmortem diffusion of ethanol‐d6 using rats." Forensic Sci. Int.76. 179-188 (1995)

    • Related Report
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  • [Publications] 大辻雅彦 他: "REMEDi‐HSシステムを用いた薬毒物分析" 法中毒. 13. 39-48 (1995)

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  • [Publications] M.Ohtsuji et al.: "Screening of antihistamine agents (diphenhydramine)with blood and urine samples by REMEDi‐HS System." Proc. of the 13th International Conference on Alcohol, Drugs and Traffic Safety. 1. 321-326 (1995)

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  • [Publications] K.Shibata et al.: "Severe hyponatremia causedby cement ingestion during carbamazepine therapy." Am.J.Emergency Med.13. 245-247 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Ohshima et al.: "A case of death due to outbreak of fire during thinner abuse." Jpn.J.Legal Med.50. 33-36 (1996)

    • Related Report
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  • [Publications] E.Morishita et al.: "Hypercoagulability and high lipoprotein(a)levels in patients with type II diabetes mellitus." Atherosclerosis. 120. 7-14 (1996)

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  • [Publications] E.Nakashima et al.: "Kinetic evidence for facllitated peritoneal transport of benzoic acid in rats." J.Pharm. Pharmacol.(in press). (1996)

    • Related Report
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  • [Publications] M.Ohtsuji et al.: "The use of REMEDi HS in emergency toxicology for a rapid estimate of drug concentrations in urine, serum and gastric samples." J.Forensic Sci.41(in press). (1996)

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  • [Publications] 橋本琢磨: "RIAとIRMA 免疫実験操作法(右田俊介、紺田進、本庶佑、濱岡利之編)" 南江堂, 298-309 (1995)

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  • [Publications] 西上 潤,大島 徹他: "固定臓器からの精神神経用剤(ジアゼパム及びクロルプルマジン)の分析" 日法医誌. 49. 補256 (1994)

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  • [Publications] 吉田 豊,大島 徹他: "薬毒物中毒例におけるREMEDi(薬物同定システム)の使用経験" 日救急医会誌. 5. 626 (1994)

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  • [Publications] 近藤稔和,大島 徹他: "出血性膵炎を伴ったカ-バメイト系殺虫剤の中毒死例" 法中毒. 12. 150-151 (1994)

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  • [Publications] 西上 潤,大島 徹他: "経口服用による覚醒剤急性中毒死の一剖検例" 法中毒. 12. 124-125 (1994)

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  • [Publications] 大辻雅彦,大島 徹他: "REMEDi-HS Systemを用いた薬毒物分析-第1報-" 法中毒. 12. 152-153 (1994)

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  • [Publications] 大辻雅彦,大島 徹他: "REMEDi-HS Systemを用いた薬毒物分析" 法中毒. 13. 38-48 (1995)

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  • [Publications] 大辻雅彦,大島 徹他: "REMEDi-HSシステムによるジフェンヒドラミンの分析及びGC-MS法による測定値との比較" 日法医誌. 49(発表予定). (1995)

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  • [Publications] Ohtsuji,M.,Ohshima,T.et al: "Screening of antihistamine agents(diphenhydramine)with urine samples by REMEDi-HS system" Proc 13th Int Conf.Alcohol Drug and traffic Safety(Aug.,1995,Adelaide). (発表予定). (1995)

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  • [Publications] 大辻 雅彦、大島 徹 他: "REMEDi-HSR Systemを用いた薬毒物分析-第1報-" 法中毒. 12(発表予定). (1994)

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  • [Publications] 西上 潤、大島 徹 他: "経口服用による覚せい剤急性中毒死の一剖検例" 法中毒. 12(発表予定). (1994)

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  • [Publications] 近藤 稔和、大島 徹 他: "出血性膵炎を伴ったカルバメート系殺虫剤による中毒死例" 法中毒. 12(発表予定). (1994)

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Published: 1993-04-01   Modified: 2016-04-21  

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