| Project/Area Number |
05404028
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
NISHIOKA Kusuki St.Marianna University School of Medicine, Professor Institute of Medical Science, 難病治療研究センター, 教授 (60049070)
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| Co-Investigator(Kenkyū-buntansha) |
SUMIDA Takayuki St.Marianna University School of Medicine, Assistant Professor, 難病治療研究センター, 助教授 (00183054)
丸山 征郎 鹿児島大学, 医学部・臨床検査医学講座, 教授 (20082282)
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| Project Period (FY) |
1993 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1995: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1994: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1993: ¥14,400,000 (Direct Cost: ¥14,400,000)
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| Keywords | HTLV-1 / retrovirus / flavivirus / apoptois / T cell receptor / HTLV-I tax遺伝子 / HTLV-I / tax遺伝子 / 単球マクロファージ / 滑膜細胞 |
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| Research Abstract |
We have identified the pathogenic virus component from Human T cell leukemia virus type-1 (HTLV-1) which strongly suggested the association of rheumatoid arthritis (RA). This gene product is HTLV-1 env-p40X and contributed in the synovial proliferation and alternation of T cell recognition process in tissue lesion. These findings are confirmed by either experimental animal models carrying this virus gene or in vitro intransfection to synovial cells.
More, recently, we have several data which suggest the flavivirus family takes some role in the pathogenesis in RA.
On the other hand, we have identified apoptotic process which takes an important role in the RA synovium proliferating and withdrawing proces molecular interaction of Fas/Fas L abnormality. This process also takes an important role in the pathophysiology and disease progression of RA.
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