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Studies on the cytokines in heart failure

Research Project

Project/Area Number 05404034
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SASAYAMA Shigetake  Kyoto University, Internal Medicine, Professor, 医学部, 教授 (70109007)

Co-Investigator(Kenkyū-buntansha) MATOBA Yoshiki  Kyoto University, Internal Medicine, Instructor, 医学部, 助手 (70239135)
MATSUMORI Akira  Kyoto University, Internal Medicine, Lecturer, 医学部, 講師 (70135573)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥34,600,000 (Direct Cost: ¥34,600,000)
Fiscal Year 1994: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1993: ¥26,600,000 (Direct Cost: ¥26,600,000)
KeywordsCytokine / Myocarditis / Heart failure / Cardiomyopathy / Virus / Interleukin / TNF / PCR / G-CSF / 強心薬 / ベスナリノン
Research Abstract

This study showed that increased circulating cytokines were detected in patients with acute myocarditis and cardiomyopathy and suggested that cytokines may play some role in the pathogenesis of myocardial injury in these diseases. In our animal model of EMC virus myocarditis, plasma tumor necrosis factor (TNF) -alpha was elevated in the acute stage and exogenously administered anti-TNF-alpha antibody improved survival and myocardial lesion, suggesting importance of TNF-alpha in the pathogenesis. Persistent expression of messenger RNA of TNF-alpha and IL-beta was seen in this model. A recently developed inotropic agent, vesnarinone was effective in the treatment of EMC virus myocarditis by its immunomodulating effect such as inhibition of production of TNF-alpha.
Vesnarinone inhibited the production of various cytokines by peripheral blood from patients with heart failure and the reduction of cytokine release may contribute to the beneficial effect of the drug in the treatment of heart failure.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (54 results)

All Other

All Publications (54 results)

  • [Publications] Tominaga M et al: "Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes." J Clin Invest. 91. 1231-1234 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki H et al: "Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis.An-SH dependent reduction of its expression and myocardial injury." J Clin Invest. 91. 2727-2733 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A et al: "Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy:Clinical and experimental studies." Clin Immunol Immunopathol. 68. 215-219 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shioi T et al: "Inhibition of cytokine production by a new inotropic agent,vesnarinone,in human lymphocytes,T cell line and monocytic cell line." Life Sci. 54. PL11-16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamada T et al: "Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus." Circulation. 89. 846-851 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A et al: "Vesnarinone,a new intropic agent,inhibits cytokine production by stimulated human blood from patients with heart failure." Circulation. 89. 955-958 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato Y et al: "Autoantibodies against vimentin in a murine model of myocarditis." Autoimmunity. 18. 145-148 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsui S et al: "Treatment of virus-induced myocardial injury with a novel immunomodulating agent,vesnarinone:suppression of natural killer cell activity and tumor necrosis factor-α production." J Clin Invest. 94. 1212-1217 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tanaka A et al: "An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis." Circulation. 90. 2051-2055 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsui S et al: "Vesnarinone Prolongs survival and reduces lethality in a murine model of lethal endotoxemia." Life Sci. 55. 1735-1741 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A et al: "Increased circulating cytokines in patients with cardiomyopathy and myocarditis." Br Heart J. 72. 561-566 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawamoto M et al: "Significance of myocardial uptake of iodine 123-labeled beta-methyl iodophenyl pentadecanoic acid:Comparison with kinetics of carbon 11-labeled palmitate in positron emission tomography." J Nucl Cardiol. 1. 522-528 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirozane T et al: "Experimental graft coronary artery disease in a murine heterotopic cardiac tらnspらnt model・" Circulation. 91. 386-392 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A: "Viral infections of the heart:Part II.Animal models:Pathological findings and therapeutic considerations." Edward Arnold, 28 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A: "Idiopathic Dilated Cardiomyopathy:Animal models for therapeutic trials of viral myocarditis.Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia." Springer-Verlag, 12 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A: "Cardiomyopathy Update 5:Viral myocarditis:Viral persistence,autoimmunity and oxygen radicals." University of Tokyo Press, 16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Anan R et al: "Cardiomyopathy Update 5:Molecular genetic analysis of familial hypertrophic cardiomyopathy." University of Tokyo Press, 8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tominaga M,Matsumori A,Horie M,Yoshida H,Okada Y.: "Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes." J Clin Invest. 91. 1231-1234 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A.Part II.Animal models: "Pathological findings and therapeutic considerations." Viral Infections of the Heart Edward Arnold, Kent. 110-137 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki H,Matsumori A,Matoba Y,Kyu B,Tanaka A,Fujita J,Sasayama S.: "Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An-SH dependent reduction of its expression and myocardial injury." J Clin Invest. 91. 2727-2733 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A,Kawai C,Yamada T,Ohkusa T,Morishima S,Tamaki N,Watanabe Y,Yonekura Y,Endo K,Konishi J,Yoshida A.: "Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy : Clinical and experimental studies." Clin Immunol Immunopathol. 68. 215-219 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A.: "Animal models for therapeutic trials of viral myocarditis." Idiopathic Dilated Cardiomyopathy Springer-Verlag, Berlin-Heidelberg-New York. 351-362 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shioi T,Matsumori A,Matsui S,Sasayama S.: "Inhibition of cytokine production by a new inotropic agent, vesnarinone, in human lymphocytes, T cell line and monocytic cell line." Life Sciences. 54. PL11-16 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamada T,Matsumori A,Sasayama S.: "Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus." Circulation. 89. 846-851 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A,Shioi S,Yamada T,Matsui S,Sasayama S.: "Vesnarinone, a new intropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure." Circulation. 89. 955-958 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato Y,Matsumori A,Sasayama S.: "Autoantibodies against vimentin in a murine model of myocarditis." Autoimmunity. 18. 145-148 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsui S,Matsumori A,Matoba Y,Uchida A,Sasayama S.: "Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone : suppression of natural killer cell activity and tumor necrosis factor-alpha production." J Clin Invest. 94. 1212-1217 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A.Viral myocarditis: "Viral persistence, autoimmunity and oxygen radicals." Cardiomyopathy Update 5 University of Tokyo Press, Tokyo. 209-224 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Anan R,Matsumori A,Tanaka H,Watkins HC,Seidman CE.: "Molecular genetic analysis of familial hypertrophic cardiomyopathy." Cardiomyopathy Update 5 University of Tokyo press, Tokyo. 93-100 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tanaka A,Matsumori A,Wan W,Sasayama S.: "An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis." Circulation. 90. 2051-2055 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsui S,Matsumori A,Sasayama S.: "Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia." Life Sci. 55. 1735-1741 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumori A,Yamada T,Suzuki H,Matoba Y,Sasayama S.: "Increased circulating cytokines in patients with cardiomyopathy and myocarditis." Br Heart J. 72. 561-566 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawamoto M,Tamaki N,Yonekura Y,Magata Y,Tadamura E,Nohara R,Matsumori A,Sasayama S,Konishi J.: "Significance of myocardial uptake of iodine 123-labeled beta-methyl iodophenyl pentadecanoic acid : Comparison with kinetics of carbon 11-labeled palmitate in positron emission tomography." J Nucl Cardiol. 1. 522-528 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirozane T,Matsumori A,Sasayama S.: "Experimental graft coronary artery disease in a murine heterotopic cardiac transplant model." Circulation. 91. 386-392 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shioi T et al: "Inhibition of cytokine production by a new inotropic agent,vesnarinone,in human lymphocytes,T cell line and monocytic cell line." Life Sci. 54. PL11-16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamada T et al: "Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus." Circulation. 89. 846-851 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsumori A et al: "Vesnarinone, a new intropic agent,inhibits cytokine production by stimulated human blood from patients with heart failure." Circulation. 89. 955-958 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sato Y et al: "Autoantibodies against vimentin in a murine model of myocarditis." Autoimmunity. 18. 145-148 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsui S et al: "Treatment of virus-induced myocardial injury with a novel immunomodulating agent,vesnarinone:suppression of natural killer cell activity and tumor necrosis factor-α production." J Clin Invest. 94. 1212-1217 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tanaka A et al: "An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis." Circulation. 90. 2051-2055 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsui S et al: "Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia." Life Sci. 55. 1735-1741 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsumori A et al: "Increased circulating cytokines in patients with cardiomyopathy and myocarditis." Br Heart J. 72. 561-566 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawamoto M et al: "Significance of myocardial uptake of iodine 123-labeled beta-methyl iodophenyl pentadecanoic acid:Comparison with kinetics of carbon 11-labaled palmitate in positron emission tomography." J Nucl Cardiol. 1. 522-528 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirozane T et al: "Experimental graft coronary artery disease in a murine heterotopic cardiac transplant model." Circulation. 91. 386-392 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsumori A: "Cardiomyopathy Update 5:Viral myocarditis:Viral persistence,autoimmunity and oxygen radicals." University of Tokyo Press, 16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Anan R et al: "Cardiomyopathy Update 5:Molecular genetic analysis of familial hypertrophic cardiomyopathy." University of Tokyo Press, 8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tominaga M et al: "Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes." J Clin Invest. 91. 1231-1234 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suzuki H et al: "Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis.An-SH dependent reduction of its expression and myocardial injury." J Clin Invest. 91. 2727-2733 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsumori A et al: "Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy:Clinical and experimental studies." Clin Immunol Immunopathol. 68. 215-219 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shioi T et al: "Inhibition of cytokine production by a new inotropic agent,vesnarinone,in human lymphocytes,T cell line and monocytic cell line." Life Sciences. 54. PL11-16 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamada T et al: "Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus." Circulation. 89. 846-851 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsumori A et al: "Vesnarinone,a new intropic agent,inhibits cytokine production by stimulated human blood from patients with heart failure." Circulation(in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsumori A: "Viral infections of the heart:Part II.Animal models:Pathological findings and therapeutic considerations." Edward Arnold, 28 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsumori A: "Idiopathic Dilated Cardiomyopathy:Animal models for therapeutic trials of viral myocarditis." Springer-Verlag, 12 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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