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Biomedical studies on the age-related changes of the sound trasduction mechanisms and its clinical applidations.

Research Project

Project/Area Number 05404057
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTOHOKU UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

TAKASAKA Tomonori  DEPT.OTOLARUNG.PROFESSOR, 医学部, 教授 (80004646)

Co-Investigator(Kenkyū-buntansha) KAWASE Tetsuaki  DEPT.OTOLARYNG.ASSIST.PROFESSOR, 医学部, 講師 (50169728)
HOZAWA Kouji  DEPT.OTOLARYNG.ASSIST.PROFESSOR, 医学部, 講師 (20199459)
IKEDA Katsuhisa  DEPT.OTOLARYNG.ASSIST.PROFESSOR, 医学部, 講師 (70159614)
NAMURA Naoki  DEPT.OTOLARYNG.ASSIST.PROFESSOR, 医学部, 講師 (20158760)
KOBAYASHI Toshimitsu  DEPT.OTOLARYNG.ASSOC.PROF., 医学部, 助教授 (80133958)
大島 猛史  東北大学, 医学部, 助手 (40241608)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥30,900,000 (Direct Cost: ¥30,900,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1994: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1993: ¥22,400,000 (Direct Cost: ¥22,400,000)
Keywordssound transduction / age-related changes of hearing / sonsory hair cells / hearing aid for aged persons / digital hearing aid / 聴覚 / 加齢変化 / 耳音響放射 / 細胞運動能 / 基底膜振動 / モンゴリアン・ジャービル / 歪成分耳音響放射 / 加齢による形態的変化
Research Abstract

Dr. Takasaka, head investigator of this research project, and his group has studied biological mechanisms of age-related changes of the sound transduction systems as well as otologic evidences of the presbycusis. This project has been accomplished by the development of the completely digitalized portable hearing aid (CLAIDHA) for elders who suffer from hearing impairment.
For the first two years since this project has started in 1995, we have mainly spent a time performing the basic biology of the peripheral sound transduction mechanisms, and the results obtained have been reported at the Midwinter Meeting of the Association for Research in otlaryngology in Florida and other otology related domestic meetings.
In July 1995, production of the CLAIDHA has finally been completed and permission for clinical application was obtained from the Ministry of Health and Welfare. Therefor, we have started audiometric clinical studies on the differential diagnosis for the presbycusis as well as on the fitting procedures for the newly developed CLAIHDA.The preliminary studies of the clinical applications for the CLAIDHA was reported at the International Conference on the New Trend of the Hearing Aid held at Bethesda, MD,USA.
As mentioned above, we have been able to contribute to the acceleration for the research in presbycusis and also to provide a newly developed aiding system for the aged peoples with hearing impairment. We would like to express our thanks to the Ministry of Eduction for providing Grant-in Aid for Scientific Reaserch (A) from 1993 to 1995.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] 池田勝久 他: "Calcium metabolization and entry induced by ・・・・" Cell Calcium. 18. 89-99 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 池田勝久 他: "Inhibition of acetylcholine-evoked Clcurrents ・・・・" Am J Resp Cell Mol Biol. 13. 449-454 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 池田勝久 他: "Cellular mechamisms in activation of Na-K-Cl ・・・・" J Membrane Biol. 146. 307-314 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川瀬哲也: "The effecfs of contralateral noise on ・・・・" Hearing Research. 91. 1-6 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高坂知節: "Cochlear Ultrastructure and its mieromechanics" 笹気出版, 343 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Suzuki Yukio Katori Katsuhisa Ikeda Tomonori Takasaka: "Carbohydrate distribution in the living utricularmacula of the guinea pig detected by lectins" Hearing Research. 87. 32-40 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Suzuki Katsuhisa Ikeda Tomonri Takasaka: "Biological characteristics of the globular substance in the otoconial membrane of the guinea pig" Hearing Research. 90. 212-218 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katsuhisa Ikeda, Masaaki Suzuki Masayuki SUzuki Tomonori Takasaka: "Calcium mobilization and entry induced by extracellular ATP in the non-sensory epithelial cell of the cochlear lateral wall." Cell Calcium. 18. 89-99 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masaaki Suzuki, Katsuhisa Ikeda, Hiroshi Sunose, Koji Hozawa, Chikashi Kusakari, Yukio Katori, Tomonori Takasaka: "ATP-induced increase in intracellular Ca2^+ concentration in thecultured marginal cell of the stria vasculatis of guinea-pig." Hearing Research. 86. 68-75 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seiji Kakehata Takeshi Yamamoto Tomonori Takasaka Norio Akaike: "Suppression if a non-selective cation conductance by substance P in cochlear outer hair cells." American Journal of Physiology. 269. C1185-C1192 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seiji Kakehata Joe Santos-Sacchi: "Membrane tension directlyshifts voltage dependence of outer hair cell motility andassociated gating charge" Biophysical Journal. 68. 2190-2197 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tetsuaki Kawase, Tomonori Takasaka: "The effects ofcontralateral noise on masked compound action potential inhumans" Hearing Research. 91. 1-6 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshimitsu Kobayashi, Toshinori Sato Masaru Toshima, Masako Ishidoya, Mitsuko Suetake, Tomonori Takasaka: "Treatment of labyrinthine fistula with interruption of the semicircular canals" Arch Otolaryngol Head Neck Surg. 121. 469-475 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Chikashi Kusakari Masato Nose Tamonori Takasaka Ryo Yuasa M.Kato K.Miyazono T.Fujita M.Kyogoku: "Immunopathological features of palatine tonsil characteristic of IgA nephropathy : IgA 1 localization in follicular dendritic cells" Clinical Experimental Immunology. 95. 42-48 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Sunose Katsuhisa Ikeda Masaaki Suzuki Tomonori Takasaka: "Voltage-activated K channel in luminal membrane of marginal cells of stria vascularis dissected from guinea pig." Hearing Research. 80. 86-92 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hozumi Motohashi Koji Hozawa Takeshi Oshima Takuji Takeuchi Tomonori Takasak: "Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice." Hearing Research. 80. 10-20 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katsuhisa Ikeda Hiroshi Sunose Tomonori Takasaka: "Ion transport mechanisms in the outer hair cell of mammalian cochlea." Progress in Neurobiology. 42. 703-717 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 池田勝久他: "Calcium mobilization and entry induced by extracellular ATP in the……" Cell Calcium. 18. 89-99 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 池田勝久他: "Inhibition of acetylcholine-evoked Cl^- currents by……" Am J Resp Cell Mol Biol. 13. 449-454 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 池田勝久他: "Cellular mechanisms in activation of Na-K-Cl cotronsport……" J Membrane Biol. 146. 307-314 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川瀬哲明他: "The effects of contralateral noise on masked compound……" Hearing Research. 24-53 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大島猛史他: "Bilateral sensorineural hearing loss……" Laryngoscope. 106. 43-48 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] TAKASAKA,T.,HOZAWA,K.etal: "Strial dysfunction caused by immune injury:apossible pathogenesis...." ImmunoblOLOGY IN OTORHINOL ARYNGOLOGY. 175-179 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] KOBAYASHI,T.et al: "Treatment of labyrinthine fistula with interruption of the semicircular canals." Arch Otolaryng Head Neck Surg. 121(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] KOBAYASHI,T.et al: "Pathogenesis of attic retraction pocket and chdeste atoma as studied by CT." Am J Otol. 15. 658-662 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,M.et al: "ATP-induced increase in intracellular Ca^<2+> concentrations in the cultured marginal cells" Hearing Res. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikeda,K.: "Involvement of Na-H exchange in intracellular pH recovery from acid load in the stria vascularis" Aeta Otolaryngol.(Stokh). 114. 162-166 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Motohashi,H.et al: "Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia(mi)mouse" Hearing Res.80. 10-20 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋辰,大山健二,池田勝久,和田仁,高坂知節: "シスブラチン投与症例におけるDPOAE" Audiology Japan. 38(発表予定). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鄭玉蓮,大山健二,朴沢孝治,和田仁,高坂知節: "スナネズミのDPOAEに対する麻酔剤の影響" Audiology Japan. 38(発表予定). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤利徳,高橋辰,大山健二,和田仁,高坂知節: "音響性聴器障害例でのDPOAEの検討" Audiology Japan. 38(発表予定). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤利徳,大山健二,和田仁,高坂知節: "感音性難聴者の聴力レベルとDPOAEレベルの相関" Audiology Japan. 36. 230-237 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大山健二,佐藤利徳,和田仁,高坂知節: "モルモットのDPOAEに対する中耳動特性の影響" Audiology Japan. 35. 666-674 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] MOGI,HONJO,ISHII,TAKASAKA: "RECENT ADVANCES IN OTITIS MEDIA" KUGLER PUBLICATIONS/AMSTERDAM/NEWYORK, 875 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.TAKASAKA,et.al.: "Age-related changes of the Mongolian gerbils cochlea." Proc.of Kyoto Satellite Symposium. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.TAKASAKA,et.al.: "Distortion Produet of Otoacoustic Emissions and Eochlear Ultrastructure" Abst.of 17th Midwinter Research Meeting of ARO. 47 (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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