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Functional Design of Glycopolymers and Synthetic Polymers Carrying Biological Ricognition Signals

Research Project

Project/Area Number 05453145
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 高分子合成
Research InstitutionNagoya University

Principal Investigator

KOBAYASHI Kazukiyo  Nagoya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10023483)

Co-Investigator(Kenkyū-buntansha) OKADA Masahiko  Nagoya University Faculty of Agriculture, Professor, 農学部, 教授 (20023103)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsSynthetic Polysaccharides / Glycopolymers / Dynamic Aspects of Natural Products Chemistry / Enzyme-Catalyzed Synthesis / Fluorinated Polysaccharides / Fine Structure Recognition / Biomimetic Materials / Glycotechnology / 分子認織
Research Abstract

Well-defined glycopolymers and synthetic polysaccharides having carbohydrate recognition signals have been synthesized.
(1) A convenient synthetic methodology via N-glycosidation has been developed to introduce biologically important, complex oligosaccharides. Amino function was introduced to the reducing terminal of N,N'-diacetylchitobiose and lactose with ammonium hydrogen carbonate and then allowed to react with rho-vinylbenzoyl chloride. Homo- and copolymerizations of rho-vinylbenzamide-beta-oligosaccharide monomers with acrylamide were carried out with azobisisobutyronitrile as initiator in dimethyl sulfoxide at 60 ゚C.
(2) Artificial glycopeptides were prepared by one-pot reaction of N,N'-diacetyl-chitobiosyl amine and lactosyl amine with the side chain carboxyl groups of polyglutaminic acid in the presence of peptide condensation reagents.
(3) Graft copolymers consiting of synthetic polymer backbone and polysaccharide grafts have been synthesized by phosphorylase-catalyzed synthesis of amylose-substituted stirene derivative and its polymerization.
(4) Regiospefcifically fluorinated stereoregular polysaccharides, 3-deoxy-3-fluoro- (1*6) -alpha-D-glucopyranan was synthesized via ring-opening polymerization of anhydro sugar derivative.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] A.Kobayashi: "Receptor-Mediated Regulation of Differentiation and Proliferation of Hepatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomatrials Sci.,Polymer Edn.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小林明: "細胞接着システムの新展開" 化学と生物. 32. 260-268 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Kobayashi: "Chemo-enzymatic Synthesis of a Glycopolymer Carrying Clustered-N-acetyl-β-lactosamine Moieties" J.Carbohydr.Chem.13. 753-766 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Matsushita: "Induction of Cytochrome P-450s and Expression of Liver-specific Genes in Rat Primary Hepatocytes Cultured on Different Extracelluar Matrices" Biosci.Biotech.Biochem.58. 1514-1516 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小林一清: "人工複合糖質高分子:生物認識能をもつ生体機能材料を目指した展開" 油化学協会誌「分子認識特集号」. 43. 960-967 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小林一清: "新タンパク質応用工学" フジテクノシステム, 印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "Neoglycocojugates:Preparation and Application" Academic Press, 23 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 赤池敏宏: "別冊日経サイエンス 糖鎖と細胞" 日経サイエンス社, 16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.242,Neoglycoconjugates,Part A,Synthesis" Academic Press, 10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.247,Neoglycoconjugates,Part B,Biomedical Applications" Academic Press, 10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Kobayashi: "Receptor-Mediated Regulation of Diffrentiation of Hapatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomaterials Sci., Polymer Edn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "Chemo-enzymatic Synthesis of a Glycopolymer Carrying Clustered-N-acetyl-lactosamine Moieties" J.Carbohydr.Chem.13. 753-766 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Matsushita: "Induction of Cytochrome p-450s and Expression of Liver-Specific Genes in Rat Primary Hepatocytes Cultured on Different Extracellular Matrices" Biosci.Biotech.Biochem.58. 1514-1516 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: Neoglycoconjugates : Preparation and Applications. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: Methods in Enzymology, Vol.242, Neoglycoconjugates, Part A,Synthesis. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: Methods in Enzymology, Vol.247, Neoglycoconjugates, Part B,Biomedical Appplications. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Kobayashi: "Receptor‐Mediated Regulation of Differentiation and Proliferation of Hepatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomaterials Sci.,Polymer Edn.(印刷中).

    • Related Report
      1994 Annual Research Report
  • [Publications] 小林明: "細胞接着システムの新展開" 化学と生物. 32. 260-268 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "Chemo‐enzymatic Synthesis of a Glycopolymer Carrying Clustered‐N‐acetyl‐β‐lactosamine Moieties" J.Carbohydr.Chem.13. 753-766 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Matsushita: "Induction of Cytochrome P‐450s and Expression of Liver‐specific Genes in Rat Primary Hepatocytes Cultured on Different Extracellular Matrices" Biosci.Biotech.Biochem.58. 1514-1516 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小林一清: "人工複合糖質高分子:生物認識能をもつ生体機能材料を目指した展開" 油化学協会誌「分子認識特集号」. 43. 960-967 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小林一清: "新タンパク質応用工学" フジテクノシステム(印刷中),

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "Neoglycoconjugates:Preparation and Applicaitons" Academic Press, 23 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 赤池敏宏: "別冊日経サイエンス 糖鎖と細胞" 日経サイエンス社, 16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.242,Neoglycoconjugates,Part A,Synthesis" Academic Press, 10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.247,Neoglycoconjugates,Part B,Biomedical Applications" Academic Press, 10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "Steric Control in Ring-opening Polymerization of 1,6-Anhydro Galactose Derivatives by Neighboring Group Participation" Polym.J.25. 49-57 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Chemical Synthesis of a Comb-shaped Branched Polysaccharide,4-0-α-Mannopyranosyl-(1→6)-α-D-mannopyranan" Carbohydr.Res.242. 161-166 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Synthesis of Amphiphilic Star-shaped Graft Copolymers Having Clustered Glucosides via Homopolymerization of a Macromonomer Obtained from Methacryloyloxyethyl α-D-Glucopyranoside" Makromol.Chem.,Rapid Commun.14. 293-302 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Kobayashi: "Glucose transporter-mediated dynamic attachment of erythrocytes onto a reducing glucose-carrying polystyrene" Proc.Jpn.Acad.,Ser.B. 69. 89-94 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 赤池敏宏: "細胞特異性材料の細胞・臓器工学的応用" 人工臓器. 1993. 286-299 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小林一清: "糖鎖認識を活用する細胞接着システム" 繊維学会誌(「糖鎖生物学の進歩と工学的応用」特集号). 49. 367-372 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小林明: "グルコーストランスポーターに着目した細胞接着材料の設計" 細胞培養. 19. 515-519 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 赤池敏宏: "生体適合性材料・生体機能材料" 糖鎖工学と医薬品開発. 274-289 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Chemo-enzymatic Synthesis of a Glycopolymer Carrying Clustered-N-acetyl-β-lactosamine moieties" J.Carbohydr.Chem.(印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Goto: "Body Distribution,Pharmacokinetic Analysis,and Binding to Asialoglycoprotein Receptors of 125I-Labeled Lactose-Carrying Polystyrene" J.Control Release. (印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Kobayashi: "Receptor-Mediated Regulation of Differentiation and Proliferation of Hepatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomaterials Sci.,Polymer Edn.4(印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] 小林明: "レセプターおよび糖輸送担体の糖認識機構を活用した細胞接着システムの新展開" 化学と生物. (印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] 小林一清: "「糖質エンジニアリングと製品化技術」" サイエンスフォーラム, 10 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Neoglycoconjugates:Preparation and Application" Academic Press(印刷中),

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Methods in Enzymology" Academic Press(印刷中),

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Kobayashi: "Methods in Enzymology" Academic Press(印刷中),

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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