| Project/Area Number |
05453205
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioorganic chemistry
|
|---|
| Research Institution | THE UNIVERSITY OF TOKUSHIMA |
|---|
Principal Investigator |
KUSUMI Takenori UNIVERSITY OF TOKYSHIMA,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (70015882)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHNO Nobuo SUMITOMO CHEMIGA INDUSTRY,CHIEF RESEARCHER, 宝塚総合研究所, 主席研究員
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1993: ¥6,000,000 (Direct Cost: ¥6,000,000)
|
|---|
| Keywords | Natural Product / pearl-oyster / allelopathic substances / insecticide / alga / marine invertebrate / Polydore / aquaculture / アレロパシー物質 / 海洋天然物 / 海藻化学成分 / 海洋養殖産業 / ホタテ貝 |
|---|
| Research Abstract |
A tiny marine invertebrate, Polydora, give serious damages to Japanese aquaculture, especially to cutivated pearl-oyster and scallop. Chemical components of marine organisms which inhibit Polydora have been search for. After establishing a good bioassay system using larval Polydora, we have found that the brown alga, Dictyota dichotoma, contains extremely active compouds. After separation by use of chromatographic methods, crenulacetal C has been isolated as the most active compoud : It kills larval Polydora at 1 ppm during 3 h. On the basis of the chemical structure of crenulacetal C,simpler compounds have been synthesized. A compound having a nonyl side chain has been found to be as active as the nautralproduct.
|
