• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Roles of brain cytokines and sympathetic nervous system in neural immune interaction during environmental stress.

Research Project

Project/Area Number 05454143
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

KATAFUCHI Toshihiko  Kyushu University, Dept.of Physiology, Associate Professor, 医学部, 講師 (80177401)

Co-Investigator(Kenkyū-buntansha) TAKE Sachiko  Kyushu University, Dept.of Physiology, Assistant Professor, 医学部, 助手 (80253425)
TAKAKI Atsushi  Kyushu University, Dept.of Physiology, Assistant Professor, 医学部, 助手 (30243934)
HORI Tetsuro  Kyushu University, Dept.of Physiology, Professor, 医学部, 教授 (00022814)
粟生 修司  九州大学, 医学部, 助教授 (40150908)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1993: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsSplenic sympathetic nerve / interleukin-1beta / interferon-alpha / corticotropin-releasing factor / prostaglandin E2 / anterventral region of the III vetricle / glial cell / long term potentiation / EP1レセプター / c-fosタンパク / アンチセンスオリゴDNA / TNF / グルタミン酸 / 第3脳室壁前腹側領域 / CRF / 内側視索前野 / 視床下部室傍核 / ナチュラルキラー細胞活性 / スライスパッチ法 / NMDA応答電流 / 視床下部視索前野 / インターロイキンIL-1beta / 血液-脳関門 / インターフェロンalpha / ナチュラルキラー(NK)細胞
Research Abstract

What we found by this project is as follows.
(1) Suppression of splenic natural killer (NK) cell activity by noradrenaline released from splenic sympathetic nerve (SSN) terminals is one of the mechanisms of immobilization-induced immunosuppression. (2) Brain IL-1beta induces reduction of cellular immunity at least partly through an activation of the SSN.(3) Immunosuppression induced by both brain IFN-alpha and IL-1beta is due to an activation of CRF system which leads to an enhancement of the SSN.(4) EP1 receptors for PGE2 are partly involved in the activation of brain CRF system. (5) The medial preoptic area (MPO) , which is the most potent acting site of IFN-alpha, is involved in the central regulation of immunity by its suppressive influence on the SSN.(6) Splenic NK activity decreases during dynamic phase of the ventromedial hypothalamus (VMH) lesiong-induced hyperphagia, while it increases during static phase. (7) An expression of c-fos protein in the MPO is important in thermoregulation during an exposure to high temperature. (8) An expression of IFN-alpha mRNA enhances by the immoblization stress in mouse. (9) Neurons in the anteroventral region of the III ventricle projecting to the MPO and the paraventricular nucleus play an important role in blood-borne cytokine-brain signal transduction. (10) Inhibition of the dorsal vagal motoneurons by IL-1beta through the prostanoids is considered to be one of the mechanisms of the IL-1beta-induced suppression of gastric acid secretion. (11) TNF-alpha inhibits the VMH neuronal activity, while TNF-beta activates it. (12) IFN-alpha suppresses the NMDA-induced inward current through the second mediators such as superoxide and nitric oxide. (13) The suppression of the NMDA-induced responses by IFN-alpha occurs only in the presence of the glial cells. PGE2 enhances the Ca^<2+> dependent K^+ current induced by glutamate. (14) IL-6 suppresses the long term potentiation in the hippocampal CA1 region.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (70 results)

All Other

All Publications (70 results)

  • [Publications] Katafuchi, T.: "Roles of sympathetic nervous system in the suppression of cytotoxicity of natural killer cells in the rat." Journal of Physiology (Lond.). 465. 343-357 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Hypothalamic obesity and neural regulation of immune functions : involvement of sympathetic nervous system." Bulletin of the Physical Fitness Research Institute. 83. 28-35 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Take, S.: "Central interferonα inhibits the natural killer cytotoxicity through sympathetic innervation." American Journal of Physiology. 265. R453-R459 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Hypothalamic modulation of splenic natural killer cell activity in rats." Journal of Physiology (Lond.). 471. 209-221 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ichijo, T.: "Central administration of interleukin-1β enhances splenic sympathetic nerve activity in rats." Brain Research Bulletin. 34. 574-553 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.: "The biphasic changes in splenic natural killer cell activity following the ventromedial hypothalamic lesions in rats." Brain Research. 652. 164-168 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "生理活性物質の生理学.ホルモンと生理活性物質." 臨床検査. 38(11)(増刊号). 20-24 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "脳と免疫のクロストーク:視床下部-交感神経系による免疫系の制御." ブレインサイエンス. 5(4). 381-387 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "脳-免疫系関連とサイトカイン.免疫疾患-state of arts." 医学のあゆみ. (別冊). 94-97 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 堀哲郎: "脳・免疫系関連と発熱." 第24回日本医学会総会会誌. II. 538-539 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "交感神経系を介する免疫調節." 第24回日本医学会総会会誌. III. 79 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Cerebellar afferents to neuroendocrine cells : implications for adaptive responses to simulated weightlessness." Endocrine Journal. 42. 729-737 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Take, S.: "Interferon-α acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." American Journal of Physiology. 268. R1406-R1410 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Niijima, A.: "The effect of interleukin-1β on the efferent activity of the vagus nerve to the thymus." Journal of the Autonomic Nervous System. 54. 137-144 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ando, T.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." American Journal of Physiology. 269. R662-R668 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Uchimura, D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." Journal of Neuroendocrinology. 8. 137-143 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafichi, T.: "Roles of cytokines in the neural-immune interactions : modulation of NMDA responses by IFNα" Neurobiology. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.: "The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity." Neurobiology. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.: "The autonomic nervous system as a communication channel between the brain and the immune system." Neuroimmunomodulation. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "NEURO-IMMUNO-ENDOCRINE NETWORKSとヒューマン・ネットワーク-第4回内藤コンファレンスに参加して-" 日本生理学雑誌. 57(2). 51-52 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "Neuro-Immuno-Endocrine Networks (I) -第4回内藤コンファレンスに参加して-" 福岡医学会雑誌雑誌. 86(3). 105-106 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 堀 哲郎: "内藤コンファレンス一神経・免疫・内分泌ネットワーク(I)" 月刊細胞. 27(7). 34-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "神経内分泌免疫学 井村裕夫,堀哲郎,村松繁編" 朝倉書店, 312 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "臨床医のための実験医学シリーズ,サイトカインと疾患 平野俊夫編" 羊土社, 151 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "神経系と免疫系の相互関連 佐藤公道編" エクセプタ・メディカ社, 89 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "脳と免疫-脳と生体防御系との関わりあい(第五章)" 共立出版, 195 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.: "Integrative and Cellular Aspects of Autonomic Functions : temperature and osmoregulation" John Libbey Eurotext Paris., 554 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片渕俊彦: "脳機能の解明-分子から病態まで-赤池紀扶,小暮久也編" 創風社, 286 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.et al.: "Roles of sympathetic nervous system in the suppression of cytotoxicity of natural killer cells in the rat." Journal of Physiology (Lond.). 465. 343-357 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Hypothalamic obesity and neural regulation of immune functions : involvement of sympathetic nervous system." Bulletin of the Physical Fitness Research Institute. 83. 28-35 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Take, S.et al.: "Central interferonalpha inhibits the natural killer cytotoxicity through sympathetic innervation." American Journal of Physiology. 265. R453-R459 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.et al.: "Hypothalamic modulation of splenic natural killer cell activity in rats." Journal of Physiology (Lond.). 471. 209-221 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ichijo, T.et al.: "Central administration of interleukin-1beta enhances splenic sympathetic nerve activity in rats." Brain Research Bulletin. 34. 547-553 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.et al.: "The biphasic changes in splenic natural killer cell activity following the ventromedial hypothalamic lesions in rats." Brain Research. 652. 164-168 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Take, S.et al.: "Interferon-alpha acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." American Journal of Physiology. 268. R1406-R1410 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Niijima, A.et al.: "The effect of interleukin-1beta on the efferent activity of the vagus nerve to the thymus." Journal of the Autonomic Nervous System. 54. 137-144 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ando, T.et al.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." American Journal of Physiology. 269. R662-R668 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Uchimura, D.et al.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." Journal of Neuroendocrinology. 8. 137-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafichi, T.et al.: "Roles of cytokines in the neural-immune interactions : modulation of NMDA responses by IENalpha" Neurobiology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.et al.: "The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity." Neurobiology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katafuchi, T.et al.: "Cerebellar afferents to neuroendocrine cells : implications for adaptive responses to simulated weightlessness." Endocrine Journal. 42. 729-737 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.et al.: The autonomic nervous system as a communication channel between the brain and the immune system.Neuroimmunomodulation (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.et al.: Immune cytokines modulate peripheral cellular immunity through the hypothalamo-sympatethic nervous system. In : Integrative and Cellular Aspects of Autonomic Functions : temperature and osmoregulation Edited by Pleschka, K., Gersberger, R.John Libbey Eurotext Paris. (125-129), 554 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hori, T.et al.: Brain Function in Hot Environment : Basic and Clinical Perspectives. Progress in Brain Research. Elsevier, Amsterdam, The Netherlands, (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Take, S.: "Interferon-α acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." American Journal of Physiology. 268. R1406-R1410 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Niijima, A.: "The effect of interleukin-1β onthe efferent activity of the vagus nerve to the thymus." Journal of the Autonomic Nervous System. 54. 137-144 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ando, T.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." American Journal of Physiology. 269. R662-R668 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Uchimura, D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." Journal of Neuroendocrinology. 8. 137-143 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katafichi, T.: "Cerebellar afferents to neuroendocrine cells: implications for adaptive responses to simulated weightlessness." Endocrine Journal. 42. 729-737 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 片渕俊彦: "脳-免疫系関連とサイトカイン.免疫疾患-state of arts." 医学のあゆみ. 別冊. 94-97 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 片渕俊彦: "交感神経を介する免疫調節." 第24回日本医学会総会会誌. III. 79 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 堀哲郎: "免疫系連関と発熱." 第24回日本医学会総会会誌. II. 538-539 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katafichi, T.: "Roles of cytokines in the neural-immune interactions: modulation of NMDA responses by IFNα" Neurobiology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hori, T.: "The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity." Neurobiology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hori, T.: "The autonomic nervous system as a communication channel between the brain and the immmune system." Neuroimmunomodulation. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 片渕俊彦: "脳と免疫-脳と生体防御系との関わりあい(第五章)" 共立出版, 195 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hori, T.: "Thermoregulation and immunity: the brain-immune interaction mechanisms. Physiological Basis of Occupational Health: Stressful Environments." SPB Academic publishing, Amsterdam, The Netherlands (in press), (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Take,S.et al.: "Interferon-α acts at the preoptic hypothalamus to reduce natural keller cytotoxicity in rats." American Journal of Physiology. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katafuchi,T.et al.: "The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats." Brain Research. 652. 164-168 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ichijo,T.et al.: "Central administration of interleukin-1β enhances splenic sympathetic nerve activity in rats." Brain Research Bulletin. 34. 547-563 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片渕 俊彦,堀 哲郎: "生理活性物質の生理学" 臨床検査. 8. 20-24 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片渕 俊彦: "視床下部-交感神経系による免疫系の制御" ブレインサイエンス. 5. 381-387 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片渕 俊彦: "第五章 脳から免疫系への通信(2)「脳と免疫」" 共立出版(堀 哲郎編),(印刷中), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片渕 俊彦,堀 哲郎: "脳-免疫系連関,脳機能の解明-分子から病態まで-" 創風社(赤池 紀扶,小暮 久也編), 286 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katafuchi,T.: "Roles of sympathetic nervous system in the suppression of cytotoxicity of splenic natural Killer cells in the rat." J.Physiol.(Lond.). 465. 343-357 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Take,S.: "Central interferon alpha inhibits the natural killer cytotoxicity through sympathetic innervation." Am.J.Physiol.265. R453-R459 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Katafuchi,T.: "Hypothalamic modulation of splenic natural killer cell activity in rats." J.Physiol.(Lond.). 471. 209-221 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ichijo,T.: "Central interleukin-Ib enhances splenic sympathetic nerve activity in rats." BrainRes.Bull.(in Press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 片渕俊彦: "神経内分泌系とサイトカイン「サイトカインと疾患」pp.56-68" 羊土社(平野俊夫編), 151 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 片渕俊彦: "脳による免疫修飾・自律神経系・機能「神経内分泌免疫学」" 朝倉書店(井村裕夫、堀 哲郎、松村 繁編), 312(171-184) (1993)

    • Related Report
      1993 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi