| Project/Area Number |
05454216
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | The Ciba University |
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Principal Investigator |
NOGAWA Koji The Chiba University School of Medicine Professor, 医学部, 教授 (40019584)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Etsuko The Chiba University School of Medicine Lecturer, 医学部, 講師 (80097427)
KIDO Teruhiko The Chiba University School of Medicine Associate Professor, 医学部, 助教授 (20167373)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1993: ¥3,300,000 (Direct Cost: ¥3,300,000)
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| Keywords | Urinary calcium / Urinary phosphorus / Urinary beta_2-microglobulin / Cd-exposed inhabitant / Cd-exposure / カドミウム暴露 / 尿中β_2-ミクログロブリン / カドミウム / 腎機能障害 / カルシウム / リン / 骨障害 / カドミウム汚染者 |
|---|
| Research Abstract |
The study was performed to make clear whether cadmium-exposure could cause urinary excretions of calcium and phosphorus. Morning urine samples were collected from 3178 persons living in Cd-polluted Kakehashi River basin and 294 persons in non-polluted areas. Mean values of urinary cadmium concentrations were higher in the persons in the cadmium-polluted areas than ones in the nonpolluted areas. However, there was no significant differences in urinary phosphorus concentrations between the Cd-exposed and nonexposed persons. Multiple regression analysis revealed that urinary calcium excretion was closely related to urinary concentrations of amino acids, sodium and cadmium. However, urinary beta_2-microglobulin was not significantly related to urinary calcium excretions.
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