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Randomazied Intervention Study of beta-carotene, Chlorophyll and Catechin on Health Effects : a study on utilizing on biological makers such as mutagenicity, natural killer activity and sister chromatid exchange.

Research Project

Project/Area Number 05454219
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HIROHATA Tomio  Kyushu Univ.Fac.Med Professor, 医学部, 教授 (50102075)

Co-Investigator(Kenkyū-buntansha) TOMITA Yoshifumi  Miyazaki Univ.Fac.Agric.Associate Professor, 農学部, 助教授 (70113230)
TOKUNAGA Shoji  Kyushu Univ.Fac.Med.Research Assistant, 医学部, 助手 (50227584)
KIYOHARA Chikako  Kyushu Univ.Fac.Med.Research Assistant, 医学部, 助手 (00169963)
HIROTA Yoshio  Kyushu Univ.Fac.Med.Associate Professor, 医学部, 助教授 (20080624)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1994: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1993: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywordsbeta-carotene / Male smokers / Lifestyle / Biomarker / Natural killer activity / Micronuclei test / Sister chromatid exchange / Intervention study / biomarker / 姉妹染色分体交換(SCE) / 小核試験(MN) / クロロフィル / 喫煙 / 無作為介入試験 / ベータカロテン / 姉妹染色分体交換 / ナチュラルキラー活性
Research Abstract

About 200 volunteers of smokers who consumed 15 or more cigarettes a day were divided at random into three groups, beta-carotene (30 mg/day), chlorophyll (120 mg/day) and control (1 mg beta-carotene/day) groups. They were followed for six months with biochemical and other measurement of blood at three months intervals. The baseline (at the initiation of the study) examination indicates that vegetables and fruits intake were positively related to beta-carotene and other carotenoid levels. Tofu intake was unexpectedly, but strongly related to decreased the levels of beta-carotene and cryptoxanthine. Alcohol consumption was strongly and inversely associated with the levels of various carotenoids.
As regards the effects of beta-carotene and chlorophyll, natural killer (NK) activities tended to decrease in 3 and 6 months later after the baseline examination for the two groups as well as for the control group.
The frequencies of sister chromatid exchange (SCE) and micronuclei (MN) decreased in 3 and 6 months later for the two study groups, but the control groups showed similar tendency.
Thus, the study did not provide clear-cut effects of beta-carotene and chlorophyll administration on selected biomarkers such as NK activities, SCE and MN frequencies.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Y.Kitamura, K.Tanaka, C.Kiyohara, T.Hirohata, Y.Tomita, M.Ishibashi, K.Kido: "Relationship of alcohol use, physical activity and dietnry habitys with serum carotenoids, retinol and alpha-tocopnerol among male Japanese smokers." Int. J.Epidemiol. 26. 307-314 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Kitamura, K.Tanaka, C.Kiyohara, T.Hirohata, Y.Tomita, M.Ishibashi and K.Kido: "Relationship of alcohol use, physical activity and dietary habits with serum carotenoids, retional and alpha-tocopherol among male Japanese smokers." Int.J.Epdemiol.26 (2). 307-314 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary

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Published: 1993-04-01   Modified: 2016-04-21  

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