| Project/Area Number |
05454227
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
YOSHIZAWA Hiroshi Hiroshima University School of Medicine, professor, 医学部, 教授 (30109954)
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| Co-Investigator(Kenkyū-buntansha) |
OGINO Takeo Hiroshima City Institute of Public Health, director, 所長 (40041850)
MORIYA Takashi Hiroshima University School of Medicine, research associate, 医学部, 助手 (40243563)
NAKANISHI Tosio Hiroshima University School of Medicine, assistant professor, 医学部, 講師 (20136089)
TANAKA Junko Hiroshima University School of Medicine, research associate, 医学部, 助手 (70155266)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1994: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1993: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | Hepatitis C virus (HCV) / Polymerase chain reaction (PCR) / HCV Genotype / Anti HCV / HCV carrier / Horizontal transmission / Vertical transmission / HCV関連抗体 / 新規発生率 / C型慢性肝炎 / polymerase chain reacion(PCR) / Genotype / branched DNA probe assay / RIBA-2 |
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| Research Abstract |
Sero-epidemiological and gene-epidemiological studies of HBV and/or HCV infection were conducted in areas showing high Stamdard Mortality Rate (SMR) by chronic liver diseases (chronic hepatitis, liver cirrhosis and hepatocellular carcinoma) and the following results were obtained.
1.It appears that the correlation between SMR and the prevalence of HBV and/or HCV carriers is not clear, that is, areas showing high SMR caused by chronic lever diseases do not necessarily show high prevalence of HBV and/or HCV carries, or vice versa. Further study is necessary to elucidate this point.
2.799 asymptomatic HCV carriers selected from blood donors were clinically diagnosed. 527 (66%) out of 799 cases were diagnosed as chronic liver disease, with one case of hepatocellular carcinoma and 7 cases of liver cirrhosis.
3.The incidence rate of horizontal and/or vertical HCV transmission was studied. In the 2-year follow up study of a total of 80,530 blood donors, there was no case of horizontal transmission and there were 2 (2.3%) cases of vertical HCV transmission from 87 HCV carrier mothers.
These findings will provided the basis for establishing strategy for control of chronic liver diseases.
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