| Project/Area Number |
05454232
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Jichi Medical School |
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Principal Investigator |
NOMIYAMA Kazuo Jichi Medical School, School of Medicne, Professor, 医学部, 教授 (80048967)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Yasuo Azabu University, Veterinary Medicine, Professor, 獣医学部, 教授 (40063961)
NOMIYAMA Hiroko Jichi Medical School, Medicne, Assistant Professor, 医学部, 講師 (70049039)
河野 慶三 自治医科大学, 医学部, 助教授 (10225378)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | Cadmium / Lead / Mercury / Blood Pressure / Hypertensive heredity / SHR rat / remnant like lipoprotein / atherosclerosis / プラバスタチン / 動脈硬化 |
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| Research Abstract |
1) Both normotensive and spontaneously hypertensive (SHR) rats were given 15 g/day pelleted food containing CdCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Cd, but was depressed in SHR rats exposed to 300 ppm Cd. This might suggest that systolic blood pressure is accelerated by Cd at a lower dose level only in subjects with hypertensive heredity. Depression in systolic blood pressure may be a sign of Cd toxicity.
2) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing PbCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Pb. This might suggest that systolic blood pressure is accelerated by Pb at a lower dose level only in subjects with hypertensive heredity. Supplemental studies suggested that age-related elevation in systolic blood pressure was accelerated more markedly by Pb at lower dose levels (0.3 and 1 ppm), and that blood pressure elevation may be accelerated by atherosclerosis through abnormal cholesterol metabolism.
3) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing HgCl_2 at a dose level of 0,1,3 10 or 30 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to all levels of Hg. Biochemical data suggested that age-related elevation in systolic blood pressure may be accelerated by atherosclerosis through abnormal cholesterol metabolism induce by Hg.
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