| Project/Area Number |
05454251
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | SHINSHU UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
TOSHIO Kobayashi SHINSHU UNIV.SCH.of MED.ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (80020775)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Kazuhiko SHINSHU UNIV.SCH.of MED.ASSOCIATE PROFESSOR, 医学部・附属加齢適応研究センター, 助教授 (70174985)
HONDA Takayuki SHINSHU UNIV.SCH.of MED.ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (80238815)
FUJIMOTO Keisaku SHINSHU UNIV.SCH.of MED.ASSISTANT, 医学部・附属病院, 助手 (70242691)
KUBO Keishi SHINSHU UNIV.SCH.of MED.ASSISTANT PROFESSOR, 医学部, 講師 (80143965)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1994: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1993: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | High altitude / Pulmonary edema / Hypoxia / Ventilatory control / Hypoxic ventilation response / Interleukin 6 / Interleukin 8 / 低酸素換気応答性 |
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| Research Abstract |
In this project four studies were performed. The results are as follows ;
A The pathway of adaptation to high altitude in Tibetan :
We measured maxiamal O_2 uptake, minute ventilation, aneaerobic threshold, blood gases and blood lactateduring maximal exercise 17 lifelong Tibetan residents and 14 acclimatized Han Chinese newcomers living at the altitude of 4,700m. Although maximal oxygen uptake was significantly lower in the Tibetans than in the HAns, at maximal exercise effort the exercise workload was greater. The Tobetans showed lower blood lactate value than did the Hans both before and at the end of exercise. We conclude that the Tibetan natives have higher exercise performance but lower maximal oxygen uptake than do acclimatized Han newcomers. These results may reflect the effects of genetic or peripheral adaptation factors in the Tibetan natives.
B Inteleulin (IL) 6 and 8 in the bronchoalveolar largel fluid (BALF) in patients with high altitude pulmonary edema (HAPE)
We measured IL6 and IL8 in BALF in four patients with HAPE on admission and on recovery. The levels of both IL6 and IL8 of BALF on admission were much higher than those on recovery. These findings suggest that IL6 and IL8 play the important roles of pathogenesis of HAPE.
C Acute hypoxic ventilatory response and hypoxic depression in HAPE
We made a original machine which was able to measure acute ventiratory response and hypoxic depression. We measured them in susceptible subjects with HAPE,using the machine. The acute hypoxic ventilatory response of the susceptible subjects : with HAPE was lower than those of controls.
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