| Project/Area Number |
05454276
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
OGAWA Satoshi Keio University, Dept.of Medicine, Professor, 医学部, 教授 (90124940)
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| Co-Investigator(Kenkyū-buntansha) |
AKAISHI Makoto Keio University, Dept.of Medicine, Associate, 医学部, 助手 (90150961)
YAMAGUCHI Kazuhiro Keio University, Dept.of Medicine, Assistant Professor, 医学部, 講師 (30129712)
MITAMURA Hideo Keio University, Dept.of Medicine, Assistant Professor, 医学部, 講師 (70129675)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | Space / Gravity / Systemic circulation / Coronary circulation / Pulmonary circulation / ventilation / perfusion imbalance / EDRF |
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| Research Abstract |
To simulate the space environment, the animals were tilted down by 10degrees.The chronically instrumented dog enabled us to measure coronary blood flow continuously were studied.In the setting of simulated space environment, there was no discernible change in coronary flow reserve assessed by reactive hyperemia created with 20-second occlusion.Although there was little increase in left ventricular volume in the setting of the simulated space environment, the blockade resulted in the augmented response of left ventricular volume to the head-down tilt.This augmentation caused the marked increase in coronary blood flow.This was probably due to increase in oxygen demand of the heart in the setting of simulated space environment.
Acetylcholine induced systemic hypotension.This response was partially inhibited by 1-Nitro Arginine Methyl Ester (1-NAME), and was completely inhibited by mucarinic-1 receptor blockade (Pirenzepine).On the other hand, the response of coronary arterial resistance to acetylcholine was hardly inhibited by 1-NAME and strongly inhibited by Pirenzepine.
To clarify the effect of high-gravity condition on pulmonary circulation, the determination of EDRF was established and the effects of low alveolar oxygen on the gravity dependent distribution of pulmonary blood flow were studied.Low alveolar oxygen redistributed the blood flow from lower lung field to upper lung field.
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