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Neurobiological Study for Demintia. -In vivo analysis of human brain using PET.

Research Project

Project/Area Number 05454297
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

FUKUDA Hiroshi  Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University. Professor, 加齢医学研究所, 教授 (30125645)

Co-Investigator(Kenkyū-buntansha) IDO Tatsuo  Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, To, サイクロトロンラジオアイソトープセンター, 教授 (80134063)
ITO Masatoshi  Division of Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku Universi, サイクロトロンラジオアイソトープセンター, 教授 (00125501)
IRIE Toshiaki  Division of Clinical Research and Radiation Health, National Institute of Radiol, 障害・臨床研究部, 主任研究官 (40160072)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsBrain / acetylcholine receptors / acetylcholine esterase activity / positron emission tomography (PET) / 痴呆 / 脳神経受容体 / アセチルコリンエステラーゼ / サル脳 / アセチルコリンエステレース
Research Abstract

In order to visualize acetylcholine neurotransmission disorders in demented patients, the following studies were performed in this year.
(1) Imaging for acetylcholine receptors : positron emission tomography (PET) with ^<11>C-benztropin, a ligand for acetylcholine receptors, were performed in 6 normal subjects. Serial arterial blood sampling was performed and the fraction of unmetabolized radio-ligand in plasma was measured by HPLC.Receptor binding potential in regional brain was estimated by Patlak plot analysis using PET images and plasma input function. Then, these data were transformed into standard brain format using anatomical standardization system (HBA) and mean and standard deviation of the binding capacity were calculated. For further development, PET studies with this ligand in aged normals and demented patients were going on.
(2) Estimation of acetylcholine esterase (AchE) activity in the brain : N-methyl-3-piperidyl ester, which we have designed as a substrate for AchE,is trapped in the brain after metabolic change by the enzyme. We have developed and established C-11 labeling of the compound. Acute toxicity in the animals and radiation dose estimation by MIRD procedure were performed, and use of this radiotracer for humans was authorized by ethical committee. Then, PET imaging of the brain with this tracer was firstly performed in a normal subject. Arterial blood sampling and analysis of metabolites in the plasma was also performed. Using PET images and plasma input function, mathematical modeling for the measurement of AchE activity in the brain were under developing. Now PET studies in normal subject and demented patients were going on.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] Hiroshi Ito: "Error analysis of Table look-up method for cerebral blood flow measurement by ^<123>I-IMP brain SPECT : Comparison with conventional microsphere model method." Annals of Nuclear Medicine. 9. 75-80 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Aging effect on neutron amino acid transport at the blood-brain barrier measured with L-|2-18F|-fluorophenylalanine and PET." Journal of Nuclear Medicine. 36. 1232-1237 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Cerebral blood flow measurement with iodine-123-IMP SPECT, Calibrated standard input function and venous blood sampling." Journal of Nuclear Medicine. 36. 2339-2342 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Rapid calculation of regional cerebral blood flow and distribution volume using Iodine-123-Iodoamphetamine and Dynamic SPECT." Journal of Nuclear Medicine. 36. 531-536 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ryuta Kawashima: "Activity in the human primary motor cortex related to arm and finger movements" NeuroReport. 6. 238-240 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshiaki Irie: "Brain acetylcholinesterase activity : validation of a PET tracer in a rat model of alzheimer's disease." Journal of Nuclear Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川島隆太: "PETによる脳機能マッピング" 医学のあゆみ. 175. 185-188 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 後藤了以: "新しい核医学三次元的頭部固定装置の作成と評価" 核医学. 32. 689-694 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 福田寛: "画像診断" 臨床と研究. 72. 43-47 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小山真道: "^<99m>Tc-HMPAO SPECTによる正常平均脳血流像の作成-解剖学的標準化による評価-" 核医学. 32. 969-977 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 福田寛: "痴呆の病態の神経生物学的研究-ポジトロンCTによるヒト脳でのインビボ解析-" INNERVISION. 8. 30- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川島隆太: "^<99m>Tc-ECD SPECTによる正常平均脳血流像の作成-解剖学的標準化による評価-" 核医学. 33. 69-72 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takehiko Fujiwara: "Quantitative Imaging of ^<11>C-Benztropine in Human Brain with Graphic Analysis and Spectral Analysis." Quantification of Brain Function Using PET. R Myers, V Cunningham, D Bailey, T Jones eds, Academic Press.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshiaki Irie: "Evaluation of phenylmethanesulfonyl fluoride (PMSF) as a tracer candidate mapping acetylcholinesterase in vivo." Nuclear Medicine Biology. 20. 991-992 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshiaki Irie: "Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo" Nuclear Medicine Biology. 21. 801-808 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroki Namba: "In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog." Brain Research. 667. 278-282 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shigeo Kinomura: "Functional anatomy of taste perception in the human brain studied with positron emission tomography" Brain Research. 659. 263-266 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ryuta Kawashima: "Activity in the human primary motor cortex related to ipsilateral hand movements." Brain Research. 663. 251-256 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masao Tada: "An efficient synthesis of Nomega- [^<18>F] fluoroacetylserotonin (Nomega- [^<18>F] -fluoroacetyl-5-hydroxytryptamine)." Journal of Labelled Compounds and Radiopharmaceuticals. 741-746 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Error analysis of table look-up method for cerebral blood flow measurement by ^<123>I-IMP brain SPECT : Comparison with conventional microsphere model method." Annals of Nuclear Medicine. 9. 75-80 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hroshi Ito: "Aging effect on neutral amino acid transport at the blood-brain barrier measured with L-[2-^<18>F] -fluorophynylalanine and PET." Journal of Nuclear Medicine. 35. 1232-1237 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Cerebral blood flow measurement with iodine-123-IMP SPECT,Calibrated standard input function and venous blood sampling." Journal of Nuclear Medicine. 36. 2339-2342 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Rapid calculation of regional cerebral blood flow and distribution volume using Iodine-123-Iodoamphetamine and dynamic SPECT" Journal of Nuclear Medicine. 36. 531-536 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshiaki Irie: "Brain acetylcholinesterase activity : validation of a PET tracer in a rat model of alzheimer's disease." Journal of Nuclear Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fujiwara T,Mejia M,Itoh M,Yanai K,Meguro K,Sasaki H,Ono S,Itoh H,Fukuda H,Iwata R,Ido T,Watabe H,Cunningham VJ,Ashburner J,Jones T: Quantitative Imaging of 11C-Benztropine in Human Brain with Graphic Analysis and Spectral Analysis. Quantification of Brain Function Using PET.Ralph Myers, Vincent Cunningham, Dale Bailey, Terry Jones eds, Academic Press, Inc. (in press)., (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Error analysis of Table look-up method for cerebral blood flow measurement by ^<123>I-IMP brain SPECT:Comparison with conventional microsphere model method." Annals of Nuclear Medicine. 9. 75-80 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroshi Ito: "Aging effect on neutron amino acid transport at the blood-brain barrier measured with L-〔2-18F〕-fluorophenylalanine and PET." Journal of Nuclear Midicine. 36. 1232-1237 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroshi Ito: "Cerebral blood flow measurement with iodine-123-IMP SPECT,Calibrated standard input function and venous blood sampling." Journal of Nuclear Medicine. 36. 2342-2339 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroshi Ito: "Rapid calculation of regional cerebral blood flow and distribution volume using Iodine-123-Iodoamphetamine and Dynamic SPECT." Journal of Nuclear Medicine. 36. 531-536 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ryuta Kawashima: "Activity in the human primary motor cortex related to arm and finger movements." NeuroReport. 6. 238-240 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toshiaki Irie: "Brain acetylcholinesterase activity:validation of a PET tracer in a rat model of alzheimer's disease." Journal of Nuclear Medicine. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川島隆太: "PETによる脳機能マッピング" 医学のあゆみ. 175. 185-188 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 後藤了以: "新しい核医学三次元的頭部固定装置の作成と評価" 核医学. 32. 689-694 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 福田寛: "画像診断" 臨床と研究. 72. 43-47 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小山真道: "^<99m>Tc-HMPAO SPECTによる正常平均脳血流像の作成-解剖学的標準化による評価-" 核医学. 32. 969-977 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 福田寛: "痴呆の病態の神経生物学的研究-ポジトロンCTによるヒト脳でのインビボ解析-" INNERVISION. 8. 30- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川島隆太: "^<99m>Tc-ECD SPECTによる正常脳血流像の作成-解剖学的標準化による評価-" 核医学. 33. 69-72 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takehiko Fujiwara: "Quantitative Imaging of ^<11>C-Benztropine in Human Brain with Graphic Analysis and Spectral Analysis." Quantification of Brain Function Using PET.R Myers,V Cunningham,D Bailey,T Jones eds,Academic Press.(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroki Namba: "In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog" Brain Research. 667. 278-282 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shigeo Kinomura: "Functional anatomy of taste perception in the human brain studied with positron emission tomography" Brain Research. 659. 263-266 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ryuta Kawashima: "Activity in the human primary motor cortex related to ipsilateral hand movements" Brain Research. 663. 251-256 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ryuta Kawashima: "Activity in the human primary motor cortex related to arm and finger movements" Neuro Report. 6. 238-240 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masao Tada: "An efficient synthesis of Nω-[^<18>F]fluoroacetylserotonin(Nω-[18F]fluoroacetyl-5-hydroxytryptamine)" Journal of Labelled Compounds and Radiopharmaceuticals. 34. 741-746 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 藤井 亮: "神経情報伝達系イメージング剤:^<11>C標識ジアシングリセロール-可容化剤の体内分布に与える影響および被爆線量の推定-" 核医学. 31. 1503-1510 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masatoshi Itoh: "Assesment of dopamine metabolism in brain of patients with dementia by means of ^<18>F-fluorodopa and PET" Annals of Nuclear Medicine. 8. 245-251 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Michinao Mizugaki: "The distribution of [11C]cocaine in Nomal and cocainesensitization Mice" Nuclear Medicine Biology. 21. 793-799 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Haruo Nagasawa: "Metabolic disturbances in exo-focal brain areas after cortical stroke studied by positron emission tomography" Journal of Neurological Sciences. 123. 961-964 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Toshiaki Irie: "Evaluation of phenylmethanesulfonyl fluoride(PMSF) as a tracer candidate mapping acetylcholinesterase in vivo" Nuclear Medicine Biology. 20. 991-992 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroki Namba: "A simple method for measuring glucose utilization of the insuline-sensitive tissues by using the brain as a reterence" European Journal of Nuclear Medicine. 21. 228-231 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Toshiaki Irie: "Design and evaluation of radeoactive acetylcholine analogs for mepping brain acetylcholinesterase(AchE) in vivo" Nuclear Medicine Biology. 21. 801-808 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ryuta Kawashima: "Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateal hand movement" Brain Research. 623. 33-40 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ryuta Kawashima: "Changes of cerebral blood flow listening to an unfamiliar spoken langage" Neurosciense Letters. 161. 69-72 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masaomi Iyo: "Dopamine D_2 and Serotonin S_2 Receptors in Susceptibility to Methamphetamine Psychoses Detected by Positron Emission Tomography" Psychiatry Research:Neuroimaging. 50. 217-231 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 福田 寛: "脳ドーパミン受容体の画像診断" 病態生理. 12. 765-771 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 福田 寛: "脳の老化-その形態と機能の画像診断-" 加齢医学研究所雑誌. 45. 1-9 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 福田 寛: "神経系の老化と検査.PET" CLINICAL NEUROSCIENCE. 11. 94-95 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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