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The Role of Radiation Therapy in The Treatment for Non-Small Cell Lung Cancer.

Research Project

Project/Area Number 05454298
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionGunma University School of Medicine

Principal Investigator

NIIBE Hideo  Gunma Univ.Sch.of Med.Radiol.& Radiat.Oncol.Professor, 医学部, 教授 (90008293)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Takashi  Gunma Univ.of Med.Radiol.& Rad.Oncol.2nd dpt.of Pathology, Professor, 医学部, 教授 (20124422)
YAMAKAWA Michitaka  Gunma Univ.of Med.Radiol.& Rad.Oncol.Assist.Prof., 医学部, 講師 (40182414)
SAITO Yoshihiro  Gunma Univ.of Med.Radiol.& Rad.Oncol.Instructor, 医学部, 助手 (50170543)
HAYAKAWA Kazushige  Gunma Univ.of Med.Radiol.& Rad.Oncol.Assist.Prof., 医学部, 講師 (70114189)
MITSUHASHI Norio  Gunma Univ.of Med.Radiol.& Rad.Oncol.Associate Prof., 医学部, 助教授 (20008585)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsNon-small cell lung cancer / Radiation therapy / Radiosensitivity / Radiation-induced apoptosis / Combined modality / Prognostic factor / Optimal dose / 非小細胞性肺癌 / 放射線治療 / 類表皮癌(扁平上皮癌) / 間期死 / アポトーシス / モノクローナル抗体
Research Abstract

In the patients with unresectable stage III NSCLC received definitive radiation therapy (RT) at Gunma University Hospital from 1976 through 1989, the five year survival rates were 12% for stage IIIA and 8% for stage IIIB respectively. By histologic types, 14% were alive at five years for squamous cell carcinoma as compared with only 3% for other histologic types. Furthermore of the patients without progression of disease at the end of two years after RT,79% of squamous cell carcinoma patients were alive free of disease after 5 years from RT.However only 17% of adenocarcinoma patients lived longer than 5 years. Our results suggested that, in NSCLC patients, squamous cell carcinoma patients were most favorable candidate for definitive RT.Our analyzes of the factors affecting survival demonstrated that the performance status was significantly correlated to prognosis among host characteristics, and that, among tumor variables, N3 stage, thoracic bony invasion and malignant pleural effusion were unfavorable prognostic factors, and that tumor size and primary sites were the significant factors on survival. For the treatment factros of RT,the portal size given over 40 Gy, that should not exceed 100 cm^2, was correlated to survival. The optimal radiation doses for squamous cell carcinoma of the lung were considered to range from 60 to 70 Gy. our Biohistological studies using human lung cancer xenograft into the nude mice demonstrated the well correlation between radiation-induced apoptosis and radio-sensitivity.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Hayakawa,K.: "Definitive radiation therapy for clinical Stage N0-N1 epidermoid carcinoma of the lung." J.Jpn.Soc.Ther.Radiol.Oncol.5. 261-269 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa,K.: "Effect of Krestin as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell cancer." Anticancer Research. 13. 1815-1820 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa,K.: "Adverse chronic effects of high-does irradiation on proximal bronchus in patients treated for bronchogenic carcinoma." The British Journal of Radiology. 66. 480-483 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki,T.: "High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection." Jpn.J.Cancer Res.85. 1087-1093 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kazumoto,T.: "Radioimmunodetection of lung cancer with IMACIS-1,I-131 labeled monoclonal antibodies to CEA and CA19-9." Annals of Nuclear Medicine. 7. 39-44 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuhashi,N.: "Establishment and characterication of a new human lung poorly differentiated adenocarcinoma cell line,GLL-1,producing carcinoembryonic antigen (CEA) and CA19-9." Lung Cancer. (in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 新部英男(分担): "Annual Review 呼吸器1995" 中外医学社, 264 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Yamakawa, M., Nakayama, Y., Katano, S., Furuta, M., Niibe, H.: "Definitive radiation therapy for clinical stage N0-NI epidermoid carcinoma of the lung." J Jpn Soc Ther Radiol Oncol. 5 (4). 261-269 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Takahashi, M., Katano, S., Shiojima, K., Furuta, M., Niibe, H.: "Effect of Krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer." Anticancer Res. 15 (3c). 1815-1820 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kazumoto, T., Mitsuhashi, N., Hayakawa, K., Yonome, I., Niibe, H.: "Radioimmunodetection of lung cancer with IMACIS-1, I-131 labeled monoclonal antibodies to CEA and CA19-9. Comparison of accumulation in irradiated and non-irradiated site" Ann Nuc Med. 7 (1). 39-44 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuhashi, N., Takahashi, T., Sakurai, H., Yamakawa, M., Hasegawa, M., Furuta, M., Matsumoto, H., Higuchi, K., Hayakawa, K., Niibe, H.: "Establishment and charac terization of a new human lung poorly differenciated adenocarcinoma cell line, GLL-1, producing carcinoembryonic antigen (CEA) and CA19-9" Lung Cancer. 12 (1,2) (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki, T., Shidara, K., Hara, F., Makajima, T.: "High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection" Jpn J Cancer Res. 85. 1087-1093 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Nakajima, N., Niibe, H.: "Adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma" Br J Radiol. 66 (785). 477-479 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Furuta, M., Hayakawa, K., Mitsuhashi, N., Saito, Y., Niibe, H.: "Second lung cancer following radiation therapy of locally advanced pulmonary cancer" Lung Cancer. 10 (3,4). 251-255 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Saito, Y., Hayakawa, K., Mitomo, O., Nakayama, Y., Katano, S., Furuta, M., Mitsuhashi, N., Niibe, H.: "Radiation therapy after non-curative resection or exploration in non-small cell lung cancer" Jpn J Lung Cancer. 34 (4). 489-495 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayakawa,K.: "Definitive radiation therapy for clinical Stage NO-N1 epidermoid carcinoma of the lung." J. Jpn. Soc. Ther. Radiol. Oncol.5. 261-269 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hayakawa,K.: "Effect of Krestin as adjuvant treatment on the prog-nosis after radical radiotherapy in patients with non-small cell cancer." Anticancer Research. 13. 1815-1820 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hayakawa,K.: "Adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma." The British Journal of Radiology. 66. 480-483 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,T.: "High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papilloma virus infection." Jpn. J. Cancer Res.85. 1087-1093 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazumoto,T.: "Radioimmundetection of lung cancer with IMACIS-1,I-131 labeled monoclonal antibodies to CEA and CA19-9" Annals of Nuclear Medicine. 7. 39-44 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mitsuhashi,N.: "Establishment and characterization of a new human lung poorly differentiated adenocarcinoma cell line, GLL-1, producing carcinoembryonic antigen (CEA) and CA19-9." Lung Cancer. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 新部英男(分担): "Annual Review 呼吸器1995" 中外医学社, 264 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Niibe,H.: "Radiation therapy for Stage I-III epidermoid carcinoma of the lung" LUNG CANCER. 8(3,4). 213-223 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Niibe,H.: "Radioimmunodetection of lung cancer with IMACIS-1,^<131>I labeled monoclonal antibodies to CEA and CA 19-9,Comparison of accumulation in irradiated and non-irradiated site" ANN Nucl Med. 1(7). 39-44 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Niibe,H.: "Short communication : Adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma" Brit J.Radiol. 66. 477-479 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Niibe,H.: "Effect of Krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer" ANTICANCER RESERCH. 13. 1815-1820 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Mitsuhashi,N.: "Second lung cancer following radiation therapy of locally advanced pulmonary cancer" LUNG CANCER. 10(3,4). 251-255 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hayakawa,K.: "Definitive radiation therapy for clinical stage NO-N1 epidermoid carcinoma of the lung" J.Jpn.Soc.Ther.Radiol.Oncol.5. 261-269 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 新部英男: "がんへの挑戦" 群馬放射線腫瘍研究会, 270 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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