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Combination Therapy of Hyperthermia and Immunotherapy with Radiation to Cancer.

Research Project

Project/Area Number 05454300
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionChiba University

Principal Investigator

MIYOSHI Takeyoshi  Chiba Univ.Radiol.Instructor., 医学部, 講師 (10114331)

Co-Investigator(Kenkyū-buntansha) 斉藤 正好  千葉大学, 医学部附属放射線技師学校, 講師
YAMAMORI H  Chiba Univ.Surg.Instructor., 医学部, 講師 (00166836)
TASHIRO A  Chiba Univ.Surg.Instructor., 医学部, 講師 (70143310)
NUNOMURA M  Chiba Univ.Surg.Assist., 医学部, 助手 (20208276)
SAITO N  Chiba Univ.Surg.Assist., 医学部, 助手 (50170519)
SAITO M  Chiba Univ.Red.Tecn.Sch.Instruct.
斎藤 正好  千葉大学, 医学部・附属放射線技師学校, 講師
竹田 明彦  千葉社会保険病院, 外科臓器不全研究室, 医員
滝口 伸浩  千葉大学, 医学部・附属病院, 医員
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1995: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsRadiation / Hyperthermia / Streptococcus preparation / OK-432 / gammadelta-T cell / Vx-2 carcinoma / Immunotherapy / Multimodal therapy / Radiation / Hyperthermia / Immunotherapy / OK-432 / γδ-Tcell / Vx-2Tumor / Thermotherapy / OK-432(ピシバニール) / γδ-T cell / Vx-2 Tumor / Recurrence of Breust Cancer / OK-IA1(HLA-DR)
Research Abstract

For advanced cancer, we studied a new protocol that both immunotherapy (Streptococus preparation, OK-432) and hyperthermia were combined with radiation. Both therapy began from experiences that malignant tumor sometimes regressed and disappeared after Erysipelas with heat. It was known that heating sensitized radiation effects and produced Heat Shock Protein (HSP) induced thermotolerance. And it was reported that OK-432 injection induced HSP production and activated gammadelta-T cell against HSP.
A)Animal studies : Experimental tumor was rabbit's Vx-2 carcinoma. Radiation was 10 MeV X-ray. OK-432 was injected arround and in tumor. Experimental group was a)Radiation alone, b)Radiation+Hyperthermia, c)OK-432+Radiation and d)OK-432+Radiation+Hyperthermia.
In group a and b, tumors temporally regressed but regrew again and all rabbits died. In group c and d, all tumor remarkablly regressed and disappeared for 25 weeks. By a reduction of radiation dose, the antitumor activity of group c was declined.
B)Clinical studies : 1)By intradermal injection of OK-432, gammadelta-T cell slightly increased. 2)By intratumoral injection, gammadelta-T cell in 26% of patients remarkablly increased in peripheral blood, and gammadelta-T cell in 26% of patients remarkablly increased in all patients. 3)Recurrenced rhabdo-myosarcoma in case one was disappeared by group c pattern's therapy.
In case 2, big and inoperable supraclavicular metastasis of operated stomach cancer and in case 3, wide spreaded skin metastasis of male operated breast cancer were completely regressed by group d pattern's therapy.
Combination therapy of immunotherapy and hyperthermia with radiation showed the same results on big rumors in animal and clinical studies. These results showed that this combination therapy would be importantly useful for advanced cancer.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 遊左昌樹,三好武美,有水昇: "温熱治療における大血管血流が加温に及ぼす影響に関する基礎的研究" 千葉医学会雑誌. 70. 189-200 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Busch, W.: "Uber den Einflusz Welhen heftigere Erysipelen zuweilen auf organizierte Neubildungen ausuben." Verhandelungen des Naturheikunde Preussen & Rheinwestphlen. 23. 28-30 (1866)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Coley, W.B.: "The treatment of malignant tumors by repeated innoculation of erysipelas with a report of 10 original cases." Amer.J.Med.Sci.105. 487-511 (1893)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Coley, W.B.: "Apreliminary note on the treatment of inoperable sarcoma by the toxic product of erysipelas." Post-graduate. 8. 278-286 (1983)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Westermark, F.: "Uber die behandelung des ulcerierende cervix carcinoma mit der konstanter waerme." Zeitblatt der Gynaekologie. 22. 1335-1339 (1898)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okamoto, H., Shoin, S.and Koshimura, S.: "Studies on the anticancer and Streptolysin S forming abilities of Hemolytic Streptococci." Japan J.Microbiol.11. 332-336 (1967)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ono, T., Kurata, M., Wakabayashi, K., Sugawara, Y., Saito, M.and Ogawa, H.: "Inhibitory effect of a streptococal preparation (OK-432) on the neucleic acid synthesis in tumor cells in vitro." Gann. 64. 59-69 (1973)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Uchida, A.and Hoshino, T.: "Clinical studies on cell mediated immunity in patients with malignant disease." Cancer. 45. 476-483 (1980)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Zocchi, M.R., Ferrarini, M.and Rugarli, C.: "Selective lysis of the autologous tumor by deltaT S1^+ gamma/delta^+ tumor-infiltrating lymphocytes from human lug carcinomas." Eur.J.Immunol.20. 2685-2689 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Valdagni, R., Amichetti, M., Pani, G.et al.: "Radical radiation alone versus radical radiation plus microwave hyperthermia for N_3 (TNMUICC) neck nodes : A prospective randomized trial." Int.Radiat.Oncol.Biol.Phys.15. 13-24 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mukai, M., Ando, K., Koike, S.and Nagao, K.: "Effect of combination therapy of radiation and local administration of OK-432 on murinee fibrosarcoma." Int.J.Radiat.Oncol.Biol.Phys.17. 125-130 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mukai, M., Morita, S.and Tsunemoto, H.: "Combination therapy of local administration of OK-432 and radiation for esophageal cancer." Int.J.Radiat.Oncl.Biol.Phys.22. 1047-1050 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumagai, K., Fujii, M., Abo, T., et al.: Characterization and idetification of LAK precarsors : Induction of double negative (CD4^-CD8^-)T cells with a cytotoxic activity by a streptococcus pyogenes preparation (OK-432). In New Horizones of Tumor Immunotherapy. Elsvier Science Publishers, 243 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 遊佐昌樹、三好武美、有水 昇: "温熱治療における大血管血流が加温に及ぼす影響に関する基礎的研究" 千葉医学会雑誌. 70. 189-200 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 遊佐昌樹,三好武美,有水 昇: "温熱治療における大血管血流が加温に及ぼす影響に関する基礎的研究" 千葉医学会雑誌. 70. 189-200 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 遊佐昌樹,三好武美,有水昇: "温熱治療における大血管血流が加温に及ぼす影響に関する基礎的研究" 千葉医学会雑誌. (印刷中). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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