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Study on Long-term Prognosis of Schizophrenia after the Introduction of Long-acting Antipsychotic drugs by Personal Examination

Research Project

Project/Area Number 05454311
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

FURUTA Hisakazu (1994)  Kanazawa University School of Medicine, Department of Neuropsychiatry, Assistant Professor, 医学部・附属病院, 講師 (80190156)

山口 成良 (1993)  金沢大学, 医学部, 教授 (00064501)

Co-Investigator(Kenkyū-buntansha) KIBA Seiko  Kanazawa University School of Medicine, Department of Neuropsychiatry, Instructo, 医学部, 助手 (50110614)
KAWASAKI Yasuhiro  Kanazawa University School of Medicine, Department of Neuropsychiatry, Instructo, 医学部・附属病院, 助手 (80242519)
HIGASHIMA Masato  Kanazawa University School of Medicine, Department of Neuropsychiatry, Instructo, 医学部・附属病院, 助手 (00173146)
KOBAYASHI Katsuji  Kanazawa University School of Medicine, Department of Neuropsychiatry, Instructo, 医学部・附属病院, 助手 (50221239)
古田 寿一  金沢大学, 医学部附属病院, 講師 (80190156)
和田 有司  金沢大学, 医学部附属病院, 講師 (30175153)
地引 逸亀  金沢大学, 医学部, 助教授 (60110532)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsLong-term prognosis / Schizophrenia / Long-acting antipsychotic drug / Haloperidol decanoate / Personal examination / haloperidol decanoate / 抗精神病薬 / 初回入院
Research Abstract

We investigated the long-term prognosis of patients with schizophrenia who were first hospitalized at the Department of Neuropsychiatry of Kanazawa University Hospital between 1978 and 1992, and compared them with the results of the surveys that were carried out in the past by using the same criteria in our department. Furthermore, we examined the prognosis of the patients who were treated by the long-acting antipsychotic drug (haloperidol decanoate) that came to be used clinically from 1987. The investigation was done by means of personal interview.
The subjects were 62 patients, 35 male and 27 female, and the present average age was 32.6 <plus-minus>9.3 years. The remission rate of all the patients, including complete remission and partial remission, was 58%. It was almost equal to the previous two reports after the introduction of pharmacotherapy. The remission rate tended to decrease in the group of patients that had the longest clinical course over 12 years. The remission rate was lower in the group of patients with the hebephrenic type in comparison with the catatonic type and the paranoid type. Generally, the outcome at the time of the first discharge from the hospital tended to correspond with the present state of the patient as the long-term prognosi
In addition, there were four patients who were treated by the long-acting antipsychotic drug. In these cases, one patient had complete remission and three patients showed partial remission, and two of the four patients had long clinical course over 12 years. However, there was no case of the hebephrenic type, although there was one case of the catatonic type and three cases were of the paranoid type. Therefore, we need larger samples to evaluate the contribution of the long-acting antipsychotic drug to the long-term prognosis of patients with schizophrenia.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 山口成良: "精神疾患と生体リズム" 神経研究の進歩. 36. 1020-1028 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川崎康弘: "MRIを用いた精神分裂病患者脳の形態的検討について" 精神神経学雑誌. 94. 960-965 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kawasaki,Y.: "A quantitative magnetic resonance imaging study of patients with schizophrenia" Eur Arch Psychiatry. 242. 268-272 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 地引逸亀: "精神分裂病と前頭葉" 神経精神薬理. 15. 513-520 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kawasaki,Y.: "SPECT analysis of regional cerebral blood flow changes in patients with schizophrenia during the Wisconsin card sorting test" Schizophrenia Research. 10. 109-116 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 和田有司: "未治療の精神分裂病患者における光駆動反応-平均加算波形による検討-" 脳と精神の医学. 4. 447-450 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川崎康弘: "日本生物学的精神医学会編,生物学的精神医学Vol.4,認知機能からみた精神分裂病" 学会出版センター, 203 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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