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A study on pathophysiology of circulatory dysfunction in immature fetuses by extrauterine fetal incubation

Research Project

Project/Area Number 05454344
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionUNIVERSITY OF TOKYO

Principal Investigator

OKAI Takashi  University of Tokyo, Dept.of Obstetrics and Gynecology, Associate Professor, 医学部(病), 助教授 (40126016)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Kouichi  University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (10262015)
RYO Eiji  University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (30221683)
FUJII Tomoyuki  University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (40209010)
UNNO Nobuya  University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (90193979)
KOZUMA Shiro  University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (10272569)
菊池 昭彦  東京大学, 医学部(病), 助手
坂井 昌人  東京大学, 医学部(病), 助手 (30251268)
菊地 昭彦  東京大学, 医学部(病), 助手
亀井 良政  東京大学, 医学部(病), 助手 (00251265)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1993: ¥3,300,000 (Direct Cost: ¥3,300,000)
Keywordsartificial placenta / fetus / cerebral blood flow / colored microsphere / oxygen consumption / ECMO / ECMO / 胎児循環 / 胎動抑制 / 異常胎仔
Research Abstract

1. The condition of isolated goat fetuses with umibilical arteriovenous extracorporeal membrane oxygenation was investigated. (1) Umbilical arteriovenous extracorporeal membrane oxygenation enabled isolated goat fetuses to survive for three weeks. (2) It was confirmed that fetal circulation was maintained with the patent ductus arteriosus during the extrauterine incubation period. (3) The fetuses maintained stable circlatory and respiratory paramaters after the postoperative period. (4) Oxygen consumption in the incubated fetuses was almost the same as the level in the intrauterine fetuses.
2. Effects of repeated umbilical cord occlusion on brain circulation in fetal goats were investigated by colored microsphere technique. (1) The blood flow to the cerebral cortex, white matter, cerebellum and medulla increased by 200-300% respectively during umbilical cord occlusion. (2) The regional blood flow in the brain increased further after the release of cord occlusion. However, it tended to decrease with the repetition of cord occlusion.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Noboru Unno, Yoshinori Kuwabara, Takashi Okai et al.: "Development of an artificial placenta : Survival of isolated goat fetuses for three weeks with umbilial A-V ECMO" Artifical Organs. 17. 996-1003 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 海野信也,木戸浩一郎,梁栄治,岡井崇: "臍帯動静脈A-V ECMOによるヤギ未熟胎仔の長期間子宮外保育法の開発-胎動抑制法の検討" 人工臓器. 22. 876-879 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 梁栄治,海野信也,岡井崇,桑原唐紀: "子宮外保育実験におけるヤギ胎仔の血漿過酸化脂質動態の検討" 人工臓器. 22. 885-889 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Unno N, Kuwabara Y, Okai T, et al: "Development of an artificial placenta : Endocrine responses of goat fetuses furing long-term extrauterine incubation with umbilical arteriovenons sxtracorpored membrane Oxygenatis" Eudocrine Journal. 41. S69-S76 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ryo, E, Okai T, Kikuchi, er al: "Thioborbiturie acid reactor substances during arteriovenous bypass in goat fetuses" Artificial Organs Today. 5. 197-206 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nobuya Unno, Yoshinori Kuwabara, Takashi Okai, Hirotoshi Nakayama, Akihiko Kikuchi, Yumiko Narumiya, Shiro Kozuma, Yuji Taketani, Masanori Tamura: "Development of an artificail Placenta : Survival of isolated goat fetuses for three weeks with unbilical A-VECMO." Artificial Organs. 17 (12). 996-1003 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Unno N,Kido K,Ryo E,Okai T,Kuwabara Y,Taketani Y.: "Long-term extrauterine incubation of premature goat fetuses using umbilical arteriovenous membrane oxygenation--The fetal immobilization method--" Japanese Journal of Artificial Organs. 22 (3). 876-879 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ryo E,Unno N,Okai T,Kuwabara Y.: "Plasma lipid peroxide concentration in extrauterine incubated goat fetuses" Japanese Journal of Artificial Organs. 22 (3). 885-889 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Unno N,Kuwabara Y,Narumiya-Takikawa Y,Takechi K,Masuda H,Ogami Y,Tsushima R,Sakai M,Baba K,Okai T,Kozuma S,Taketani Y: "Development of an artificail placenta : Endocrine responses of goat fetuses during long-term extrauterine incubation with umbilical arteriovenous extracoporeal membrane oxygenation." Endocrine Journal. 41 (Suppl). S69-S76 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ryo E,Okai T,Kikuchi A,Kobayashi K,Nashina H,Sakai M,Kagawa H,Unno N,Kozuma S,Taketani Y: "Kuwbara Y.Thiobarbituric acid reactive substnaces during arteriovenousbypass in goat fetuses" Artificail Organs Today. 5 (3). 197-206 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡井崇、上妻志郎 他: "人工子宮による胎仔保育実験" 進歩する心臓研究. 14. 6-12 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] N.Unno,T.Okai et al: "Development of an Arrificial:Endocrine Response" Endocrine Journal. 41. 69-76 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡井崇、海野信也、他: "人工子宮による胎仔保育実験" 進歩する心臓研究. 14. 6-12 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 海野信也、岡井崇、他: "臍帯動静脈A・V ECMOによるヤギ未熟胎仔の長期間子宮外保育法-胎動抑制法の検討" 人工臓器. 22. 876-879 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梁栄治、岡井崇、他: "子宮外保育実験におけるヤギ胎仔の血漿過酸化脂質動態の検討" 人工臓器. 22. 885-889 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Unnc,T.okai,et al.: "Development of an Artificial Placenta:Survival of Isolated Goat Fctuses for Three Weeks with Umbilical Arteriovenous Extracorporeal Membrane Oxygenation" Artificial Organs. 17. 996-1003 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Unnc,T.okai,et al.: "Development of an Artificial Placenta:Endocrine Responses of Goat Fetuses during Long-Term Extrauterine Incutation with Umbilical Arteriovenous Extracorporeal Membrane Oxygenation" Endocrine Journal. 41(Suppl). S69-S76 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 海野信也,岡井崇他: "臍帯動静脈A-V ECMOによるヤギ未熟胎仔の長期間子宮外保育法-胎動抑制法の検討" 人工臓器. 22. 876-879 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡井崇,海野信也他: "人工子宮による胎仔保育実験" 進歩する心臓研究(予定). 14. (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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