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Development of magnetically suspended centrifugal pump (MSCP) and operation system

Research Project

Project/Area Number 05454384
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

BAN Toshihiko  Kyoto University, Faculty of Medicine, Department of Cardiovascular Surgery Professor, 医学研究科, 教授 (00173120)

Co-Investigator(Kenkyū-buntansha) AKAMATSU Teruaki  Kyoto University, Faculty of Engineering, Department of Mechanical engineering P, 工学部, 教授 (40025896)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1995: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsMagnetically suspended centrifugal pump / Assist heart / Left ventricular assist / Hemolysis test / Thrombus / Long-term animal experiment / Coating / 溶血 / 抗血栓性 / エネルギー効率 / 温度上昇
Research Abstract

To overcome problems derived from the shaft within conventional centrifugal pump, we have developed a magnetically suspended centrifugal pump (MSCP) , which operates as a bearingless sealless centrifugal pump. The impeller is suspended freely and centrally by magnetic force within the pump. Hemolysis tests were performed in comparison with the Biopump. Index of hemolysis and destruction of platelets were significantly lower in the MSCP.Animal studies were designed to evaluate antithrombogenecity and durability of the MSCP.Short-term animal studies in which several coating methods on the impeller of the pump were investigated showed that silicon coating was best with results of no thrombus on the surface after continuous pumping for 24 hours. Long-term animal studies were performed using 5 sheep weighing 40 - 50 kg. The left heart by pass was established with a withdrawal cannula into the left atrium and a return cannula into the descending aorta. Heparin was given for anticoagulation only at cannulation, and Warfarin was orally administrated subsequently to keep the prothrombin time 1.5 to 2.0 folds. Five sheep survived more than two weeks with 46 days of the longest survival. The pump flow rate obtained during the pumping was 3.0 to 5.0 l/min. The free hemoglobin concentration was less than 20 mg/dl, and other parameters relating biochemistry were within normal ranges. The cause of termination was thrombus formation in the cannula in two, systemic infection in one, gastrointestinal disturbance in one, and thrombus inside the pump in one sheep, that was the longest survival. These results suggest that the MSCP could be durable for at least more than a month, and is promising for application of long-term circulatory assist device, whch is mandatory to rescue patients with the profound heart failure.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Akamatsu T: "Recent studies of centrifugal blood pump with a magnetically suspended impeller." Artif Organs. 19(7). 631-634 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akamatsu T: "Recent development of a centrifugal blood pump with a magnetically suspended impeller" Artificial Heart. 4. 305-308 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Park CH: "Development of a magnetically suspended centrifugal pump-in vitro and in vivo assessment" ASAIO Journal. 41. M345-350 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 朴 昌禧: "長期使用を目的にした新しい遠心ポンプ(磁気浮上遠心ポンプ)のin-vitroにおける性能評価" 人工臓器. 24. 809-814 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura K: "Development of magnetically suspended centrifugal pump as a cardiac assist device for long-term application." ASAIO Journal. 25. in press (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akamatsu T.: "Recent studies of centrifugal blood pump with a magnetically suspended impeller." Artif Organs. 19(7). 631-634 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akamatu T.: "Recent development of a centrifugal blood with a magnetically suspended impeller." Aetificial Heart. 4. 305-308 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Park CH.: "Development of a magnetically suspended centrifugal pump-in vitro and in vivo assessment." ASAIO Jouranl. 41. M345-350 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Prak CH.: "In-vitro Analysis of A New Centrifugal Pump "Magnetically Suspended Centrifugal pump" for Long Term Cardiac Assist." Jpn J Artif Organs. 24(3). 809-814 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura K.: "Development of magnetically suspended centrifugal pump as a cardiac assist device for long-term application." ASAIO Journal. 25 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akamatsu T: "Recent studies of centrifugal blood pump with a magnetically suspended impeller." Artif Organs. 19(7). 631-634 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akamatsu T: "Recent development of a centrifugal blood with a magnetically suspended impeller" Artificial Heart. 4. 305-308 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Park CH: "Development of a magnetically suspended centrifugal pump-in vitro and in vivo assessment" ASAIO Journal. 41. M345-350 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 朴昌禧: "長期使用を目的にした新しい遠心ポンプ(磁気浮上遠心ポンプ)のin-vitroにおける性能評価" 人工臓器. 24. 809-814 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura K: "Development of magnetically suspended centrifugal pump as a cardiac assist device for long-term application." ASAIO Journal. 25(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Chang-Hee Paek: "A New Centrifugal Pump “Magnetically Suspended Centrifugall Pump"" Artificial Organs. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Teruaki Akamatsu: "Recent Studies of the Centrifugal Bood Pump with a Magnetically Suspended Impeller" Artificial Organs. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 朴 昌禧: "長期使用を目的にした遠心ポンプ(磁気浮上ポンプ)の開発とその有望性について" 人工臓器. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Chang-Hee Park: "Heart Replacement 5" Springer-Verlag Tokyo (in press), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Akamatsu: "Recent Developement to a Centrifugal Blood Pump with a Magnetically Suspended Impeller." Artificial Heart. 4. 305-308 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Akamatsu: "Studies on Performance and Operating Condition of Centrifugal Blood Pump with Magnetically Suspended Impeller" Int.Soc.for.Rotary Blood Punp. 1(suppl). 18-18 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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