• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on Tracheal Prosthesis using promotive materials for tissue regeneration

Research Project

Project/Area Number 05454385
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

NAKAMURA Tatsuo  Kyoto University, Res.Ctr.Biomed.Engr Vice Professor, 生体医療工学研究センター, 助教授 (70227908)

Co-Investigator(Kenkyū-buntansha) IKADA Yoshito  Kyoto University, Res.Ctr.Biomed.Engr.Professor, 生体医療工学研究センター, 教授 (00025909)
HITOMI Shigeki  Kyoto University, Chest Disease Ins.Professor, 胸部疾患研究所, 教授 (80173186)
SHIMIZU Yasuhiko  Kyoto University, Res.Ctr.Biomed.Engr.Professor, 生体医療工学研究センター, 教授 (00027111)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1994: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1993: ¥4,400,000 (Direct Cost: ¥4,400,000)
KeywordsArtificial tracheal / Biocompatible material / Tracheal segmental reconstruction / Collagen / Marlex mesh / Collagen sponge / Omentpexy / 人工食道 / 気管・気管支形成術 / マーレックスメッシュ / 人工臓器
Research Abstract

(1) We replaced the intrathoracic trachea of dogs'using our tracheal prosthesis. The tracheal prosthesis consists of Marlex mesh (polypropylene mesh) reinforced with a continuous polypropylene spiral, which is grafted and coated with porcine dermal collagen. At the operation the air leakage from the tracheal prosthesis and anastomotic site were minimal. All the prosthesis were completely incorporated with the host tissue. However, the exposure of mesh to tracheal lumen were more remarkably observed than in the previous experiment of replacement at the cervical trachea.
(2) In order to overcome this problem, we added omentpexy to the intrathoracic tracheal replacement prosedure. As the result, the regeneration of neomucosa was faster and more complete than in the previous replacements without omentopexy. Moreover, in histological study, the epithelial regeneration were faster and more complete. But, since there were still remain in some dogs, stenoses of tracheal lumen furter improvement is requiered to promote the epithelial regeneration.
(3) Therefore, we manufactured a new tracheal prosthesis to promote the regeneration of neomucosa. This prosthesis consists of tthe same as the prosthesis used in the experiment (1) as a bulk on which collagen sponge made from porcine dermal collagen was laminated.We replaced dog's cervical tracheae using this prosthesis. This new trachea could partially overcome the 2 major problems such as stenosis of the lumen and exposure of the mesh. However, since collagen sponge easily came off from the cylinder of mesh, the complications at the anastomotic sites is consider to be ready to occure. As the air leakage from this trachea were lethal in some intrathoracic replacements, the use of collagen sponge appeared not so effective than expected.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-高張力下での吻合に関して-" 人工臓器. 22(3). 1025-1030 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Norihito Okumura: "A New Trocheal Prosthesis Made from Collagen Grafted Mesh" ASAIO Journal. 39(3). M475-M479 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "人工気管による気管再建の研究" 気管支学. 15(8). 772-777 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Norihito Okumura: "Experimental reconstruction of the intrathoracic trachea using a new prosthesis made from collagen groftedrnes." ASAIO Journal. 40(3). M834-M839 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-胸腔内気管への応用に関して-" 人工臓器. 23(3). 878-882 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Norihito Okumura: "Experimental Study on a new tracheal prosthesis made from collagen conjugated mesh" J.Thorac.Cardiovasc.Surg.108(2). 337-345 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masayoshi Teramachi: "A new prous type tracheal prosthesis sealed with collagen sponge." ASAIO Abstract. (in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Norihito Okumura: "Experimintal study on a new tracheal prosthesis made from collagen-grafted mesh" ASAIO Abstract. 102- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "人工気管による気道再建の研究" 気管支学. 15(4). 88- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究" 日本胸部外科学会雑誌 臨時増刊号. 41. 1999- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-胸腔内気管への応用に関して-" 人工臓器. 22. 163- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Norihito Okumura: "Experimental reconstruction of the intrathoracic trachea using a new prosthesis made from collagen-grofted mesh" ASAIO Abstract. 103- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 寺町政美: "コラーゲン加工メッシュ製人工気管の実験的研究" 日本呼吸器外科学会誌. 8(3). 287- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 寺町政美: "コラーゲンスポンジを用いたメッシュ式人工気管の実験的研究" 日本胸部外科学会雑誌 臨時増刊号. 42. 1626- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masayoshi Teramach: "A new prous type tracheal prosthesis seald with collagen sponge" ASAIO Abstract. 93- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村典仁: "人工臓器1994-95" 中山書店, 312 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study of a tracheal prosthesis made form collagen-grafted mesh ; investigation of anastomosis under high tension" J Jpn Artifi.Organs. 22 (3). 1025-1030 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "A New Tracheal Prosthesis Made form Collagen Grafted Mesh" ASAIO Journal. 39 (3). M475-479 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on the prosthetic reconstruction of airway" J Jpn Soc.for Bronchology. 15 (8). 772-777 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental reconstruction of the intrathoracic trachea using a new prosthesis made form collagen grafted mesh" ASAIO Journal. 40 (3). M834-839 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on a new tracheal prosthesis made from collagen grafted mesh ; investigation of application to intrathoracic tracheai replacement" J Jpn.Artif.Organs. 23 (3). 878-882 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh" J.Thorac.Cardiovasc.Surg.108 (2). 337-345 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Teramachi: "A new porous type tracheal prosthesis sealed with collagen sponge" ASAIO Journal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on a new tracheal prosthesis made from collagen-grafted mesh" Abstract of the 39th Annual Meeting of ASAIO. 102. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on the prosthetic reconstruction of airway" J.Jpn.Soc.for Bronchology. 15 (4). S-8 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on a tracheal prosthesis made from collagen-grafted mesh" 41 Supplement of Jpn.Assc.for Thoracic Surg.1999. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental study on a new tracheal prosthesis made from collagen grafted mesh ; investigation of application to intrathoracic tracheal replacement" Transaction of Jpn.J.Artifi.Organs. 22. 163 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Experimental reconstruction of the intrathoracic trachea using a new prosthesis made from collagen-grafted mesh" Abstract of the 40th Annual Meeting of ASAIO. 103. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Teramachi: "Experimental study on a porous type tracheal prosthesis made from collagen-grafted mesh" Supplement of the 11th annual meeting of Jpn.Assc.for Chest Surgery. 287. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Teramachi: "Experimental study on a new porous type tracheal prosthesis sealed with collagen sponge" 42 Supplement of Jpn.Assc.for Thoracic Surg.1626. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Teramachi: "A new porous type tracheal prosthesis sealed with collagen sponges" Abstract of the 41th Annual Meeting of ASAIO. 93. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Okumura: "Artificial Trachea" Artificial Organs. 1994-95. 221-224 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshito Ikada: "Experimental reconstruction of the intrathoracic trachea using a new prosthesis made from collagen grafted mesh" ASAIO Journal. 40(3). M834-M479 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 筏 義人: "コラーゲン加工メッシュ製人工気管の実験的研究-胸腔内気管への応用に間して-" 人工臓器. 23(3). 878-882 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 清水 慶彦: "コラーゲン加工メッシュ製人工気管の実験的研究" 日本呼吸器外科学会雑誌. 8(3). 287- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 清水 慶彦: "コラーゲンスポンジを用いたメッシュ式人工気管の実験的研究" 日本胸部外科学会雑誌. 42. 1626- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 清水 慶彦: "人工臓器1994-95" 人工気管, 312 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Norihito Okumura: "A New Tracheal Prosthesis Made from Collagen Grafted Mesh" ASAIO Journal. 39(3). M475-M479 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-高張力下での吻合に関して-" 人工臓器. 22(3). 1025-1030 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 奥村典仁: "人工気管による気道再建の研究" 気管支学. 15(8). 772-777 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Norihito Okumura: "Experimental Study on a New Tracheal Prosthesis Made from Collagen-Conjugated Mesh" The Journal of Thoracic and Cardiovascular Surgery. (in print).

    • Related Report
      1993 Annual Research Report
  • [Publications] Norihito Okumura: "Experimental Study on a New Tracheal Prosthesis Made from Collagen-grafted Mesh" ASAIO Abstracts. 102 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 奥村典仁: "人工気管による気道再建の研究" 気管支学. 15(4). 318 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究" 日本胸部外科学会雑誌. 41(臨時増刊号). 401 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-胸腔内気管への応用に関して-" 第31回日本人工臓器学会大会 予稿集. 163 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 清水慶彦: "生体内吸収性材料の臨床応用" Progress in Medicine. 13(11). 2595-2598 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Norihito Okumura: "Experimental Reconstruction of the Intrathoracic Trachea Using a New Prosthesis Made from Collagen-grafted Mesh" Preliminary Program of ASAIO Meeting. 18 (1994)

    • Related Report
      1993 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi