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Targeting thermo-chemotherapy for malignant brain tumor using thermosensitive liposome and local hyperthermia

Research Project

Project/Area Number 05454394
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

TANAKA Ryuichi  NIIGATA UNIV., BRAIN RES.INST., PROFESSOR, 脳研究所, 教授 (30018816)

Co-Investigator(Kenkyū-buntansha) WATANABE Masato  NIIGATA UNIV., BRAIN RES.INST., ASSISTANT, 脳研究所, 助手 (30221691)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsthermosensitive liposome / thermochemotherapy / malignant brain tumor / targeting therapy / 温熱化学療法 / ターゲッティング療法
Research Abstract

Malignant glioma responds poorly to chemotherapy presumably mainly because the antitumor drugs can not be delivered in effective concentrations to the tumor site without causing complications, and because the existence of the blood-brain barrier (BBB) restricts the distribution of many antitumor drugs to malignant gliomas. We used thermosensitive liposomes containing CDDP(CDDP-liposome) with localized heating, and the possibilities of this drug delivery system to the brain tumor were discussed. First, this unique and attractive strategy showed remarkable effects against the subcutaneous tumor. The authors then investigated the antitumor effect on rat malignant brain tumor. The brain tumor heating was given using a radiofrequency antenna which was designed at our institute. As a result, the rats treated by CDDP-liposome+hyperthermia had the longest survival time, and the tumor CDDP level of this group was the highest when compared to other groups. These findings suggest that the combination of thermosensitiveliposome and localized hyperthermia could 1)bring a direct thermal killing of the tumor cells, plus 2)increase a permeability of the BBB to transport of CDDP,plus 3)target CDDP-liposomes to the tumor site and produce an effective release of liposomal CDDP with greater activity than when free CDDP was infected .

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] K.Kakinuma: "Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia" Jaurnal of Neurosurgery. 84. 180-184 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Drug delivery to the brain using thermosensitive liposome and local hyperthermia" International Journal of Hyperthermia. 12. 157-165 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Antitumor Effect of CDDP-entrapping Thermosensitive Liposome Combined with Local hyperthermia against Rat Malignant Glioma" Hyperthermic Oncology in Japan '93. 197-198 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋 英明: "脳腫瘍に対する温熱治療のための温度シミュレーション-二次元有限要素解析によるcomputersimulation-" Jpn.J.Hyperthermic Oncol.11. 356-364 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia" Jaurnal of Neurosurgery. 84. 180-184 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Drug delivery to the brain using thermosensitive liposome and local hyperthermia" International Journal of and Hyperthermia. 12. 157-165 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Antitumor Effect of CDDP-entrapping Thermosensitive Liposome Combined with Local hyperthermia against Rat Malignant Glioma" Hyperthermic Oncology in Japan'93. 197-198 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Takahashi: "Computer simulation of temperature distribution for brain tumor hyperthermia using the two dimmensional finite elements method." Jpn.J.Hyperthermic oncol. 11. 356-364 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kakinuma: "Antitumor Effect of CDDP-entrapping Thermosensitive Liposome Combined with Local hyperthermia against Rat Malignant Glioma" Hyperthermic Oncology in Japan'93. 197-198 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 柿沼 健一: "Targeting Chematherapy for malignant brain tumor using thermosensitive liposme and local hyperthermia" 新潟大学脳研究所業積集. 26. 85 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 柿沼 健一: "実験的脳腫瘍に対する熱感受性ポリソームと局所温熱治療法の治療効果の検討" 新潟大学脳研究所業積集. 26. 86 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kakinuma: "Targeting Therapy for Malignant Brain Tumor using Thermosensitive Liposome" Hyperthermic Oncology-in Japan. 393-394 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 柿沼 健一: "熱感受性liposomeと局所温熱療法を用いた悪性脳腫瘍に対するTargeting療法" 新潟大学脳研究所業績集. 24. 80 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] 柿沼 健一: "熱感受性liposomeと局所温熱療法を用いた悪性脳腫瘍に対するTargeting療法(第2報)" 新潟大学脳研究所業績集. 25. 91 (1992)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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