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Involvement of L-arginine-nitric oxide pathway in cerebral vasospasm

Research Project

Project/Area Number 05454396
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KIKUCHI Haruhiko  Kyoto Univ.Facalty of Medicine, Professor, 医学部, 教授 (20072746)

Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1994: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1993: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsCerebral Vasospasm / Subarachnoid Hemorrhage / Nitric Oxide / 一酸化窒素合成酵素
Research Abstract

Although cerebral vasospasm is one of the major complications after subarachnoid hemorrhage, its pathogenesis remains to be elucidated. Cerebral circulation is regulated by vasoactive substances released from vasoactive substances such as EDRF (i.e.NO) , endothelin, and also by neurotransmitters from perivascular nerve fibers such as CGRP,VIP,SP,NO.We investigated in the present study the possible involvement of NO in the occurrence of cerebral vasospasm after subarachnoid hemorrhage. Experimental subarachnoid hemorrhage was produced in rats and dogs by injecting autologous arterial blood into the cistema magna.Severe vasospasm was obtained in basilar arteries on Day 1 in rats and Day 3 in dogs. Immunopositive materials for NO synthase in the endothelium and in the adventitial nerve fibers of major cerebral arteries were reduced after subarachnoid hemorrhage, and NO mediated endothelium dependent vasorelaxations and NO mediated neurogenic vasorelaxations were impaired after subarachnoid hemorrhage. These results indicated that the impairement of NO mediated vasorelaxation mechanisms might be involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 野崎和彦: "脳血管攣縮の病態" 脳神経外科速報. 3. 647-652 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 野崎和彦: "脳血管壁NO合成酵素(NOS)含有神経線維" スパズムシンポ講演集,脳血管攣縮. 9. 16-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 野崎和彦: "脳循環調節におけるNOの役割" 血管. 17. 39-44 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kazuhiko Nozaki: "Pathogenesis of Cerebral Vasospasm" Neurosurgery Letters. Vol 3. 647-652 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kazuhiko Nozaki: "Role of Nitric oxide in Cerebral Circulation" Blood Vessel (in Japanese). Vol 17. 39-44 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 野崎 和彦: "脳血管攣縮の病態" 脳神経外科速報. 3. 647-652 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野崎 和彦: "脳血管壁NO合成酵素(NOS)含有神経線維" スパズムシンポ講演集,脳血管攣縮. 9. 16-23 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野崎 和彦: "脳循環調節におけるNOの役割" 血管. 17. 39-44 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野崎和彦: "脳血管攣縮の病態" 脳神経外科速報. 3. 647-652 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 野崎和彦: "脳血管壁NO合成酵素(NOS)含有神経線維-くも膜下出血後の変化について-" スパズムシンポ講演集. 9. (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 野崎和彦: "脳循環調節におけるNOの役割" 血管. 17. (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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