| Project/Area Number |
05454398
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | SHIMANE MEDICAL UNIVERSITY |
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Principal Investigator |
YAMASAKI Toshiki Department of Neurosurgery, Shimane Medical University Associate Professor, 医学部, 助教授 (50201835)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Seiichi Department of Neurosurgery, Instructor, 医学部, 助手 (80180454)
KAMEI Tsutomu Shimane Institute of Health Science, Dvision of Medical Research, Chief Research, 研究部長
ENOMOTO Kouichi Department of Physiology, Instructor, 医学部, 助手 (70112125)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | brain neoplasm / molecular biology / calcium signaling / proto-oncogene / major histocompatibility complex antigen / nerve impulse / elderly / computed imaging / グリオーマ / 分化 |
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| Research Abstract |
1. Role of histocompatibility antigen gene and proto-oncogene expressions in intracerebral tumorigenicity of mouse neuroblastoma.
2. Effect of calcium blocker and tumor necrosis factor-alpha on the membrane potential of cultured neuroblastoma-glioma hybrid cells.
3. Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line.
4. Clinical significance of Doppler ultrasound and endoscopic intraoperative monitoring in the stereotactic neurosurgery.
5. Clinical role of single photon emission computed tomography (SPECT) in preoperative discrimination of brain neoplasms.
6. Clinical investigation of multimodel treatments consisting of surgery, radiotherapy, chemotherapy and immunotherapy for malignant brain neoplasms.
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