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Intracellular calcium signaling in malignant brain tumor cells and new application to the management of the brain neoplasms

Research Project

Project/Area Number 05454398
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionSHIMANE MEDICAL UNIVERSITY

Principal Investigator

YAMASAKI Toshiki  Department of Neurosurgery, Shimane Medical University Associate Professor, 医学部, 助教授 (50201835)

Co-Investigator(Kenkyū-buntansha) NAGAO Seiichi  Department of Neurosurgery, Instructor, 医学部, 助手 (80180454)
KAMEI Tsutomu  Shimane Institute of Health Science, Dvision of Medical Research, Chief Research, 研究部長
ENOMOTO Kouichi  Department of Physiology, Instructor, 医学部, 助手 (70112125)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsbrain neoplasm / molecular biology / calcium signaling / proto-oncogene / major histocompatibility complex antigen / nerve impulse / elderly / computed imaging / グリオーマ / 分化
Research Abstract

1. Role of histocompatibility antigen gene and proto-oncogene expressions in intracerebral tumorigenicity of mouse neuroblastoma.
2. Effect of calcium blocker and tumor necrosis factor-alpha on the membrane potential of cultured neuroblastoma-glioma hybrid cells.
3. Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line.
4. Clinical significance of Doppler ultrasound and endoscopic intraoperative monitoring in the stereotactic neurosurgery.
5. Clinical role of single photon emission computed tomography (SPECT) in preoperative discrimination of brain neoplasms.
6. Clinical investigation of multimodel treatments consisting of surgery, radiotherapy, chemotherapy and immunotherapy for malignant brain neoplasms.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report

Research Products

(43 results)

All Other

All Publications (43 results)

  • [Publications] Yamasaki T: "Extended survival with high quality of life in patients with primary intracerebral non-Hodgkin's lymphoma:Report of 4 cases." Surgical Neurology(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Analysis of intra-and intercellular calcium signaling in a mouse malignant glioma cell line." Journal of Neurosurgery. 81. 420-426 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Intraoperative use of Doppler ultrasound and endoscopic monitoring in the stereotactic biopsy of malignant brain tumors." Jourmal of Neurosurgery. 80. 570-575 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Intratumoral administration of tumor necrosis factor-α for malignant gliomas.-Two case reports-." Neurologia medico-chirurgica. 34. 216-220 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Role of histocompatibility antigen gene and proto-oncogene expressions in intracerebral tumorigenicity of mouse neuroblastoma" Journal of Neurosurgery. 78. 619-629 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Chemotherapeutic-effects of intra-arterial administration of ACNU in primary intracerebral non-Hodgikin's lymphoma." Surgical Neurology. 40. 383-389 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "神経電気活動に及ぼす腫瘍壊死因子の作用に関する基礎的検討." 医学のあゆみ(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "培養株化神経細胞の膜電位と興奮性インパルスに及ぼすカルシウム拮抗剤(Nilvadipine)の影響" 脳神経外科. 22. 327-331 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "膠芽腫に対するIFN‐β・MCNU+VP16・放射線併用療法の効果." Biotherapy. 8. 471-472 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 秋山恭彦: "Natural Killer細胞活性に及ぼすグリチルリチンの効果.第一報-マウス悪性グリオーマ細胞株を用いた基礎的検討-." Minophagen Medical Review. 39. 134-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 秋山恭彦: "Natural Killer細胞活性に及ぼすグリチルリチンの効果.第2報-グリチルリチンの至適投与に関する基礎的検討-." Minophagen Medical Review. 39. 259-262 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "マクロファージのグリオーマ細胞に対する抗腫瘍活性の発現機構の基礎的検討." 神経免疫研究. 6. 328-332 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "脳腫瘍に対する自然抵抗性の関与する免疫監視機構の実験的検討." 神経免疫研究. 6. 80-83 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "アンギオテンシン変換酵素阻害剤の培養株化神経細胞における膜電位と興奮性インパルスに及ぼす影響." 脳と神経. 45. 1039-1044 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎俊樹: "脳における自然抵抗性免疫機構の基礎的解析." Minophagen Medical Review. 38. 109-112 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大山憲治: "活性化Mφのグリオーマ細胞傷害作用に及ぼすγ型インターフェロンの影響に関する実験的検討." 脳と神経. 45. 525-530 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: Nagai M 編集,Springer‐Verlag press社27HC01:Brain Tumor Research and Therapy(in press),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Clinical PET in Oncology" Matsuzawa T 編集,World Scientific press社, 6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line." Journal of Neurosurgery. 81. 420-426 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Intraoperative use of Doppler ultrasound and endoscopic monitoring in the stereotactic biopsy of malignant brain tumors." Journal of Neurosurgery. 80. 570-575 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Intratumoral administration of tumor necrosis factor-alpha for malignant gliomas. -Two case reports-." Neurologia medico-chirurgica. 34. 216-220 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Experimental analysis of proto-oncogene and histocompatibility antigen gene expressions during brain tumor progression." Brain Tumor Research and Therapy Nagai M (Ed), Springer-Velag Press. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Role of SPECT in evaluating the malignancy of intracranial neoplasms." Clinical PET in Oncology, Matsuzawa T (Ed), World Scientific Press. 111-116 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Experimental analysis of effects of tumor necrosis factor-alpha on electro-physiological activity in cultured neuronal cells" Igaku no ayumi. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells" Neurological Surgery. 22. 327-331 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Multimodal treatment of glioblastoma multiforme with interferon-beta・MCNU+VP16・radiation" Biotherapy. 8. 471-472 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Akiyama Y: "Effect of glycyrrhizin on natural kill cell activity. Part 1. Experimental analysis with mouse malignant glioma cell line." Minophagen Medical Review. 39. 134-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Akiyama Y: "Effect of glycyrrhizin on natural kill cell activity. Part 2. Experimental analysis on optimal dosage of glycyrrhizin." Minophagen Medical Review. 39. 259-262 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Experimental analysis of cytotoxic effector mechanism mediated by macrophages against glioma cell in mice" Neuroimmunological Research. 6. 328-332 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Experimental analysis of intracerebral immunosurveillance mechanism with reference to natural immunity against brain neoplasm" Neuroimmunological Research. 6. 80-83 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Effect of enalaprilat, an angiotensin converting enzyme inhibitor, on the membrane potential of cultured neuroblastoma-glioma hybrid NG 108-15 cells" Brain and Nerve. 45. 1039-1044 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Experimental analysis of natural resistance immune mechanism in the brain." Minophagen Medical Review. 38. 109-112 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohyama K: "Effects of interferon-gamma on cytotoxicity of murine activated macrophages against murine glioma cells" Brain and Nerve. 45. 525-530 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamasaki T: "Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line." Journal of Neurosurgery. 81. 420-426 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki T: "Intraoperative use of Doppler ultrasound and endoscopic monitoring in the stereotactic biopsy of malignant brain tumors." Journal of Neurosurgery. 80. 570-575 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki T: "Intratumoral administration of tumor necrosis factor-α for malignant gliomas.-Two case reports-." Neurologia medico-chirurgica. 34. 216-220 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山崎俊樹: "培養株化神経細胞の膜電位と興奮性インパルスに及ぼすカルシウム拮抗剤(Nilvadipine)の影響" 脳神経外科. 22. 327-331 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山崎俊樹: "神経電気活動に及ぼす腫瘍壊死因子の作用に関する基礎的検討." 医学のあゆみ. (印刷中).

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki T: "Brain Tumor Research and Therapy" Nagai M 編集,Springer-Verlag press 社 (in press),

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki T: "Clinical PET in Oncology" Matsuzawa T 編集,World Scientific press 社, 6 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki T: "Role of histocompatibility antigen gene and proto-oncogene expressions in intracranial tumorigenicity of mouse neuroblastoma." Journal of Neurosurgery. 78. 619-629 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山崎俊樹: "アンギオテンシン変換酵素阻害剤の培養株化神経細胞における膜電位と興奮性インパルスに及ぼす影響." 脳神経. 45. 1039-1044 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamasaki T: "Chemotherapeutic effects of intra-arterial administration of ACNU in primary intracerebral Non-Hodgkin's lymphoma." Surgical Neurology. 40. 383-389 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-03-31   Modified: 2016-04-21  

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