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Stereotactic laser balloon hyperthermia treatment

Research Project

Project/Area Number 05454402
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

HARA Mitsuhiro  Kyorin University Neuro. Surg. Prof., 医学部, 教授 (30086607)

Co-Investigator(Kenkyū-buntansha) SAKUMA Tadashi  Kyorin University Neuro. Surg. Staff, 医学部, 助手
KONISHI Yoshifumi  Kyorin University Neuro. Surg. Staff, 医学部, 助手
SAITO Isamu  Kyorin University Neuro. Surg. Prof., 医学部, 教授 (20186927)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1994: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1993: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordslaser / hyperthermia / stereotactic surgery
Research Abstract

To establish the stereotactic laser balloon hyperthermia treatment for the deep seated small malignant glioma, the experimental study of the interstitial hyperthermia treatment using the Nd : YAG laser unit was reported. The Ultra Line^<TM> fiber (Heraeus Laser Sonics, Inc.) was inserted into the 6F silicone balloon catheter. The laser fiber transmits the laser beam laterally (80゚C). And the balloon was inflated with physiological saline to make the tumor's tissue around the laser fiber hypoxic state. This state means to enhance the thermal effect for tumors
The laser power was 5W.The computer was programd with specific parameters to maintatin the 10 mm tissue temperature apart from laser fiber through feed back control at 45゚C.In this condition. 45 minutes hyperthermia treatment was done for the rat's implanted subcutaneous glioma. The thermal damaged area of the tumor was detected the fun-shaped according to the laser beam (10 mm thickness and 100 degree angle). And by rotating the laser fiber in the balloon catheter, the direction of the laser beam can be changed for the tumor's extention.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 原充弘: "脳神経外科におけるレーザー治療" 日本外科系連合学会誌. 19(4). 115-118 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 原充弘: "定位的laser温熱治療による悪性腫瘍の治療-第一報-" 日演発表:第53回日本脳神経外科学会総会,1994年10月,徳島.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 原充弘: "脳神経外科におけるレーザー治療の現況と展望" 日演発表:第19回日本外科学会連合学術集会,1994年6月,神戸.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 原 充弘: "脳神経外科におけるレーザー治療" 日本外科系連合学会誌. 19(4). 115-118 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 原 充弘: "定位的laser温熱療法による悪性脳腫瘍の治療-第一報-" 口演発表:第53回日本脳神経外科学会総会,1994年10月,徳島.

    • Related Report
      1994 Annual Research Report
  • [Publications] 原 充弘: "脳神経外科におけるレーザー治療の現況と展望" 口演発表:第19回日本外科系連合学術集会,1994年6月,神戸.

    • Related Report
      1994 Annual Research Report
  • [Publications] 原 充弘: "定位的laser温熱療法による悪性膿腫瘍の治療-基礎実験-" 第53回日本脳神経外科学会講演集. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sawa H,Kamada K,Sato H,Kondo A, Saito I,Edlund M,Obrink B: "C-CAM expression in the developing rat central nervous system." Dev,Brain Res. (in press). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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