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Experimental and Clinical Follow-up Studies of Vascularized Bone Grafts

Research Project

Project/Area Number 05454406
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHirosaki University

Principal Investigator

TOH Satoshi  Hirosaki Univ.School of Medicine, Associate Prof., 医学部, 助教授 (30142863)

Co-Investigator(Kenkyū-buntansha) INOUE Sadahiro  Hirosaki Univ.School of Medicine, Assistant, 医学部附属病院, 助手 (30241459)
TSUBO Kenji  Hirosaki Univ.School of Medicine, Assistant, 医学部, 助手 (20180044)
NARITA Shunsuke  Hirosaki Univ.School of Medicine, Assistant, 医学部附属病院, 助手 (00261446)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1994: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1993: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsVascularized Bone Graft / Fibula / Iliac Bone / Aseptic Necrosis of the Femoral head / Congenital Pseudoarthrosis / Tibia / Hypertrophy / Muscle Sleeve / 移植骨 / 大腿骨頭壊死 / muscle sleeve / 臨床 / 基礎 / 創外固定 / 先天性下腿偽関節症
Research Abstract

1).Osseous Changes in Muscle Sleeves Attached to Vascularized Bone Grafts
a) Experimental Study : Following transplantation, muscle sleeves lapsed into degeneration such as fatty change and fibrosis, interposing between grafted bones and graft floors, and interfering with bony fusion. However, free bone grafts between graft floors and muscle sleeves induced new bone formation around the vascularized grafted bone, leading to hypertrophy of the grafted bone and obvious bony fusion between vascularized bones and graft floors. Bony fusion between grafted bones and graft floors was apparently promoted through the muscle sleeves when free bone was grafted around the circumference of the vascularized grafted bone.
b) Clinical Study : When an allo or autograft was closely placed parallel to the vascularized fibula or the vascularized fibula was close to the intramedullary surface of the recipient bone, new bone formed from the parallel bone or recipient bone, developing to the edges and nearest … More points of the vascularized fibula. Bony fusion was also achieved in one case of iliac bone chips packed between the vascularized fibula and recipient bone.
2).Hypertrophy of the Grafted Fibula
Clinical study showed proper stress to the grafted bone helps achieve hypertrophy of the grafted fibula. Using external fixation for postoperative immobilaization is preferable, even in congenital pseudoarthrosis of the tibia.
3).Pediculated Vascularized lliac Bone Graft for Aseptic Necrosis of the Femoral Head (ANFH)
joint preserving operations for ANFH have unresolved problems. Our procedure using a pediculated vascularized iliac bone graft with deep cicumflex iliac artery was evaluated. Meticulous division of the vascular pedicle of the iliac bone, and proper direction and depth of the grafted bone are very important for good results.
Indications are Stage I and Stage II cases which are involved, and Stage III cases with wide lesion areas. For these Stage III cases, combining this method with transtrochanteric rotational osteotomy is recommended. Less

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 成田 俊介: "高齢者の整形外科的感染症に対する治療経験" 日本骨・関節感染症研究会誌. 7. 126-130 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 新井弘一: "血管柄付骨移植に関する実験的研究-muscle sleeveを介した骨癒合について-" 日整会誌. 68. 1559-1559 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 熊沢やすし: "大腿骨頭懐死に対する骨頭温存手術" 日整会誌. 68. 171-171 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 坪 健司: "血管柄付腓骨移植術を施行した先天性下腿偽関節症に対する創外固定の応用" 日本創外固定研究会誌.6. 61-65 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤 哲: "先天性下腿偽関節症に対する血管柄付き腓骨移植術の治療上の工夫" 日整会誌. 69. 59-59 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 成田俊介: "高齢者の骨関節感染症とその治療" M B Orthp.8. 27-36 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 熊沢やすし: "私のすすめる整形外科的治療" 金原出版, 102-106 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤 哲: "マイクロサージャリー:最近の進歩" 克誠堂, 279-293 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Schunsuke Narita, et.al.: "The treatments for the Infected Desiese in Orthopaedic of the elder patients." Proc Jpn Soc Bone Jt Infec. 7. 126-130 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Schinichi Arai, et.al.: "Experimental Studies of Vascularized Bone Graft" J.Jpn.Orthop.Assoc.68. S1559 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasushi Kumazawa, et.al.: "Joint Preserving Operations for the Aseptic Necrosis of the Femoral Head" J.Jpn.Orthop.Assoc.68. S171 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenji Tsubo, et.al.: "Applications of the External Fixator for the Congenital Pseudoarthrosis of the Tibia treated by the Vascularized Fibula Grafts" The Journal of the Japanese Society of External Fixation. 7. 61-65 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Satoshi Toh et.al.: "The Treatment of the Congenital Pseudoarthrosis of the Tibia using Free Vascularized Fibula Grafts" J.Jpn.Orthop.Assoc.69. S59 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Schunsuke Narita, et.al.: "The treatments for the Bone and Joint Infection in the elder patients." M B Orthop. 8. 27-36 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasushi Kumazawa, et.al.: "The treatments for the Aseptic Necrosis of the Femoral Head using combined methods of Vascularized lliac Bone graft and Anterior Rotatory Osteotomy" Orthopedics MOOK,Kanehara Inc. 102-106 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Satoshi Toh: "Microsurgery : Recent Advance" Plastic and Reconstructive Surgery, Kokuseido Inc.279-293 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 坪 健司: "血管柄付腓骨移植術を施行した先天性下腿偽関節症に対する創外固定の応用" 日本創外固定研究会誌. 6. 61-65 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤 哲: "先天性下腿偽関節症に対する血管柄付き腓骨移植術の治療上の工夫" 日整会誌. 69. S59 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 坪 健司: "Reconstruction of The Spine and Extrmities Using Vascularized Fibula Grafts." J Reconstr Microsurg,. 11. 288 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 熊沢やすし: "大腿骨頭壊死に対する骨頭温存手術" 日本マイクロ会誌.8. 58 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 成田俊介: "高齢者の骨関節感染症とその治療" M B Orthop.8. 27-36 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤哲: "マイクロサージャリー:最近の進歩" (原科孝雄編),克誠堂,東京, 303 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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