| Project/Area Number |
05454422
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIYA Ikuto Osaka Unuv, Anesthesiology, Professor, 医学部, 教授 (80028505)
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| Co-Investigator(Kenkyū-buntansha) |
MASHIMO Takashi Osaka Unuv, Anesthesiology, Assistant Professor, 医学部, 助教授 (60157188)
八木 正晴 大阪府立病院, 麻酔科 (50198644)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1994: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | Imidazoline veceptors / Halothane anesthesia / Epinephrine induced arrhythmias / Idazoxan / Rauwolscine |
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| Research Abstract |
The aim of this investigation to elucidate the role of central imidazoline receptrors (IRs) on halothane-epinephrine arrhythmias in the dogs. The results of our investigation is as follows.
1-Intarvenous administration of rilmenidine, which is selective IRs agonist prevent halothane-epinephrine arrhythmias dose dependent manner.
2-The antiarrhythmic effect of rilmenidine is blocked by intracicternal idazoxan, an IRs antagonists, but not rauwolscine, a classical a2 adrenoceptor antagonist.
These results suggest that rilmenidine prevents halothane-epinephrine arrhythmias through central IRs.
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