| Project/Area Number |
05454425
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | YOKOHAMA CITY UNIVERSITY |
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Principal Investigator |
KUDOH Ichida YOKOHAMA CITY UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (30145700)
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| Co-Investigator(Kenkyū-buntansha) |
OHTAKE Mika YOKOHAMA CITY UNIVERSITY,SCHOOL OF MEDICINE,INSTRUCTOR, 医学部, 助手 (20233158)
NISHIZAWA Hideo YOKOHAMA CITY UNIVERSITY,SCHOOL OF MEDICINE,INSTRUCTOR, 医学部, 助手 (30244479)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | ASPIRATION / PNEUMONIA / PENTOXIFYLLINE / TNF / ENDOTHELIUM / EPITHELIUM / 透過性 / 誤嚥性肺炎 / TNF-alpha / 好中球 / Myeloperoxidase |
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| Research Abstract |
1. Pulmonary epithelial and endothelial permeability were studied in rabbits whose right lung was instilled acid. Both permeability of the right lung and endothelial permeability of the left lung were increased. Pentoxifyline injected before acid-instillation prevented the increase of endothelium in the left lung.
2. TNF-alpha and neutrophil activation (H2O2) were increased 1 and 2 hour after the acid-instillation. Wet to dry weight ratio and myeloperoxidase in both lungs and the small intestine were increased. Pentoxifylline prevented those changes in the left lung and the small intestine. The effects of antiserum to TNF injected before the acid-instillation were investigated. The effects were similar with those by pentoxifylline.
3. Acid-instillation into one lung induced the interstitial edema in the contralateral lung and the small intestine. Neutrophils sequestered in these organs activated by the increased TNF-alpha may have increased the endothelial permeability. Pentoxifylline which inhibits TNF-alpha production by macrophage and neutrophil activation prevented the inflammatory reactions induced by the acid-instillation into lungs.
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