| Project/Area Number |
05454431
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
YAMANAKA Hidetoshi Gunma University School of Medicine Professor, 医学部, 教授 (70110393)
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| Co-Investigator(Kenkyū-buntansha) |
FUKABORI Yoshitatu Gunma University School of Medicine Assistant, 医学部, 助手 (90199167)
YUASA Hisako Gunma University School of Medicine Assistant, 医学部, 助手 (50240148)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Benign Prostatic Hypertrophy / Stroma / Estrogen / Androgen / Collagen / Smooth muscle / 精嚢間質 / 好酸球浸潤 / TGF-β / 動物モデル / イメージアナライザー |
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| Research Abstract |
The goal of this sudy is to invesitigate the pathogesisis of Benign Prostatic Hypertrophy (BPH) from the previously not mentioned stand point and to estabulishthe new theory regarding pharma-cotherapy for BPH.In the term of project, we have gotton the following results.
1).the mechanism of stromal proliferation of male accessory sex organs. : We demonstated by the histological investigation that the histological feature of the seminal vesicle in the immature castrates treated with estradiol 17-beta resembled that of fibromuscular type of human BPH (H.Yuasa et al.Acta Urol.Jpn, 39,1993) By further investigation, we showed that estrogen treatment to the immature castrates caused proliferative changes of both collagen and smooth muscle in the seminal vesicle (Y.Ono et al, Tohoku J.EXP.Mod, 175,1995). Moreover, we clarified by biochemical and biomolecular techniques that estrogen receptors were related to the estroge induced proliferation of collagen and smooth muscle in the seminal vesicle.
2).Analysis of collagen biosynthesis of human BPH stromal cells (In Vitro) : We demonstrated that androgen reduction stimulated the production of collagen type I and III in human BPH stromal cells in vitro implicated in the effect of TGF- beta. However, estrogen did not directly stimulate the production of collagen type I and III (Y.Fukabori et al.presented at AUA anual meeting, Las Vegas, 1995)
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