| Project/Area Number |
05454437
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
OKAMURA Kunihiro Tohoku University School of Medicine, Department of Obstetrics and Gynecology, associate Professor, 医学部, 助教授 (90124560)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Yoshitaka Tohoku University School of Medicine, Department of Obstetrics and Gynecology, a
木村 芳孝 東北大学, 医学部・附属病院, 助手 (40261622)
谷川原 真吾 東北大学, 医学部・附属病院, 助手 (90207176)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | power spectral analysis / Fetus / fetal heart rate / fluctuation |
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| Research Abstract |
Fetal heart rate monitoring has been widely used for early detection of fetal demise in current clinical settings.
Interpretation of fetal heart rate tracing is sometimes indecisive, especially when the fetus is premature. In contrast to adult heart rates, frequency analysis of fetal heart rate fluctuation has been unsuccessful. We succeeded in measurement of beat-to-beat intervals of fetus using non-invasive Doppler ultrasound. A dual peak was observed in around 0.1 cycle/beat range, which mainly shows the sympathetic nerve activity of the fetus.In animal experiments, using fetal sheep, this peak designated "Low Frequency Area, LFA" is well correlated with the fetal condition. Namely, it decreases in size as fetus becomes acidosis. In clinical settings, this system may well be correlated with fetal blood gas values.
In near future, this system will become alternative fetal monitoring to conventional fetal heart rate tracing.
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