• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The action mechamisms of bioactive substances in follicular fluid related to human ovarian folliculogenesis and dysfunction

Research Project

Project/Area Number 05454438
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionGunma University, School of Medicine

Principal Investigator

IBUKI Yoshito  Gunma University, School of Medicine, Obstetrics and Gynecology, Professor, 医学部・産婦人科, 教授 (40008256)

Co-Investigator(Kenkyū-buntansha) MINEGISHI Takashi  Gunma University, School of Medicine, Obstetrics and Gynecology, Associate Profe, 医学部・産婦人科, 講師 (00209842)
HASEGAWA Yoshihisa  Gunma University, School of Medicine, Obstetrics and Gynecology, Associate Profe, 医学部・産婦人科, 講師 (40092001)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsInhibin / Activin / Follistatin / FSH receptor / LH / CG receptor / Gonadotropin / アクチビンレセプター / hCGレセプター / CAMP / mRNA
Research Abstract

The function of ovary and folliculogenesis is regulated by both hormones and local autocrine/paracrine factors. Many kinds of bioactive substances exist in follicular fluid. Inhibin, activin and follistatin from porcine and/or bovine follicular fluid were isolated in our laboratory. We are successful in cloning of human FSH receptor, human LH/CG receptor and rat activin receptor type II,also. In order to elucidate the regulatory mechanisms of folliculogenesis, it is important to study the endocrine, paracrine and autocrine factors produced in ovary. We tried to purify bioactive substances from follicular fluid and studied functions of bioactive substances and gonadotropin receptors. Inhibin was purified to homogeniety from human follicular fluid with an immunoaffinity chromatography though it's concentration was much lower in human follicular fluid. The study of activin on gonodotropin receptors demonstrated that activin-A enhanced the FSH receptor mRNA and the FSH induced LH/CG receptor mRNA.We also demonstrated that actvin was the strongest activator of follistatin production and that both cAMP and PMS facilitated follistatin production.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (82 results)

All Other

All Publications (82 results)

  • [Publications] Nakamura M.: "Effect of an activin A on FSH receptor messenger rebonucleic acid levels and FSH receptor expression in cultured rat granulosa cells." Endocrinology. 133. 538-544 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ito I.: "Developmental changes of activin and FSH receptor mRNA and plasma FSH and inhibin levels in rat testes." Life Science. 53. 1299-1307 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minegishi T.: "structure and regulation of LH/hCG receptor." Endocrine Journal. 40. 275-287 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shenker A.: "A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty." Nature. 365. 652-654 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka: "Thyrotropin,likeluteinizinghormone(LH) and chorionic gonadotropin(CG), increase cAMP and inositol phosphate levels in cells with recombinant human LH/CG receptor." Biochem.Biophys.Res.Comm.196. 187-195 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gunji K.: "Recombinant thyrotropin stimulates cAMP formatin in CHO-K1 cells expressing recombinant chorionic gonadotropin receptor." Biochem.Biophys.Res.Comm.197. 1530-1535 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakamkura K.: "Effect of activin on LH/hCG receptor messenger rebonucleic acid in granulosa cells." Endocrinology. 34. 2329-2335 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minegishi T.: "Functional expression ofthe recombinant human FSH receptor." Journal of Endocrinology. 141. 369-375 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi S.: "Functional expression of recombinant human luteinizing hormone/human choriogonadotropin receptor." Biochem.Biophys.Res.comm.201. 248-256 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka A.: "Thyrotropin Stimulation of the Lutropin/Choriogonadotropin Receptor:Different Sites Mediate Agonist Activity and High Affinity Binding." Thyroid. 4. 447-457 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasegawa Y.: "Activin as Autocrine and Paracrine Factor in The Ovary." Horn.Res.41. 55-62 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kamijo T.: "In Vitro Fertilization of Androgen Sterilized Mice." Life Science. 55. 527-531 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takagi T.: "Changes in Serum Immunoreactive Inhibin during Ovulation Induction in Women with Amenorrea." Endocrine J.41. 703-708 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizunuma H.: "Serum Immunoreactive Inhibin Levels in Polycystic Ovarian disease (PCOD) and Hypogonadotropic Amenorrhea." Endocrine J.41. 409-414 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minigishi T.: "Regulation of follicle-stumulating hormone receptor messenger ribonucleic acid levels in cultured rat granulosa cells." Molecular and Cellular Endocrinology. 108. 67-73 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tano M.: "Regulation of follistatin messenger rebonucleic acid in cultured rat granulosa cells." Molecular and Cellular Endocrinology in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 峯岸敬: "ヒトLH/hCG,FSHレセプターの構造" 医学のあゆみ. 166. 762-762 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 石本一也: "ラット顆粒膜細胞のInhibin分泌に対するActivinAとラットFSHの分泌増強効果" 北関東医学. 43. 55-61 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 長谷川喜久: "インヒビン.アクチビン" 産婦人科の実際. 42. 1835-1839 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 中村和人: "LH/hCGの作用とレセプター" 産婦人科の実際. 42. 1811-1814 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 峯岸敬: "家族性思春期早発症とLH/hCGレセプター" Molecular Medicine. 31. 1208-1212 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi M.: "Role of Inhibins and Activins in Female Reproduction." Advances in Human Reproduction The Parthenon Publishing Group.New York Moeloek F.A. et al eds., 4 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi M.: "Role of Inhibins and Activins in Reproduction" Molecular Basis of Reproductive Endocrinclogy Springer-Verlag,New York Leung P.C.K. et al eds., 13 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasegawa Y.: "Progree with Human and Rat Inhibin Characterization." Inhibin and Inhibin-Related Proteins Ares-Serono Symposia Publications,Rome Burger H.G.et al eds., 20 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 峯岸敬: "LH,hCG,FSHレセプター レセプター 井村祐夫 他 編" 朝倉書店, 7 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 長谷川喜久: "下垂体前葉細胞の培養法 生殖機能細胞の培養法 菅原七郎 他 編" 学会出版センター, 10 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 五十嵐正雄: "Inhibin 産婦人科学書1 生殖医学 森宗英 他 編" 金原出版, 8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 長谷川喜久: "家畜繁殖 繁殖のホルモン 加藤征史郎 編" 朝倉書店, 14 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 長谷川喜久: "インヒビンとアクチビン 図説産婦人科13 生殖と神経内分泌 加藤順三 他 編" メジカルビュー社, 11 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakamura M., Minegighi T., et al.: "Effect of an activin A on FSH receptor messenger ribonucleic acid levels and FSH receptor expression in cultured rat granulosa cells" Endocrinology. 133. 538-544 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ito I., Minegishi T.et al.: "Developmental changes of activin and FSH receptor mRNA and plasma FSH and inhibin levels in rat testes" Life Science. 53. 1299-1307 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minegishi T., Nakamura K., and Ibuki Y.: "Structure and regulation of LH/hCG receptor" Endocrine Journal. 40. 275-287 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shenker A., Laue L., Kosugi S., Meredino M.Jr., Minegishi T.and Gordon B.C.Jr.: "A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty" Nature. 365. 652-654 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka A., Minegishi T.and Kohn D.L.: "Thyrotropin, like luteinizing hormone (LH) and chorionic gonadotropin (CG), increase cAMP and inositol phosphate levels in cells with recombinant human LH/CG receptor" Bochem.Biophys.Res.Comm.196. 187-195 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gunji K., Endo T., Ohno M., Minegishi T., and Onaya T.: "Recombinant thyrotropin stimulates cAMP formatin in CHO-K1 cells expressing recombinant chorionic gonadotropin receptor" Bochem.Biophys.Res.Comm.197. 1530-1535 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakamura K., Nakamura M., Igarashi S., Miyamoto K., Eto Y., Ibuki Y., and Minegighi T.: "Effect of activin on LH/hCG receptor messenger ribonucleic acid in granulosa cells" Endocrinology. 34. 2329-2335 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minegishi T., Igarashi S., Nakamura K.et al.: "Functional expression of the recombinant human FSH receptor" Journal of Endocrinology. 141. 369-375 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi S., Minegishi T.et al.: "Functional expression of recombinant human luteinizing hormone/human choriogonadotropin receptor" Bochem.Biophys.Res.Comm.201. 248-256 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka A., Ban T., Panesar N.S., Minegishi T., Kohn L.D.and Tahara K.: "Thyrotropin Stimulation of the Lutropin/Choriogonadotropin Receptor : Different Sites Mediate Agonist Activity and High Affinity Binding" Thyroid. 4 (4). 447-457 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasegawa Y.et al.: "Activin as Autocrine and Paracrine Factor in The Ovary" Horn Res. 41 (suppl 1). 55-62 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kamijo T.et al.: "In Vitro Fertilization of Androgen Sterilized Mice" Life Science. 55 (7). 527-531 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takagi T.et al.: "Changes in Serum Immunoreactive inhibin during Ovulation Induction in Women with Amenorrea" Endocrine J.41 (6). 703-708 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizunuma H.et al.: "Serum Immunoreactive inhibin Levels in Polycystic Ovarian Disease (PCOD) and Hypogonadotropic Amenorrhea" Endocrine J.41 (4). 409-414 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Minegishi T., Tano M., Nakamura K., Karino S., Miyamoto K., and Ibuki Y.: "Regulation of follicle-stumulating hormone receptor messenger ribonucleic acid levels in cultured rat granulosa cells" Molecular and Cellular Endocrinology. 108. 67-73 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tano M., Minegishi T., Nakamura K., Nakamura M., Karino S., Miyamoto K., and Ibuki Y.: "Regulation of follistatin messenger ribonucleic acid in cultured rat granulosa cells" Molecular and Cellular Endocrinology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi M.et al.: Role of Inhibins and Activins in Female Reproduction. Advances in Human Reproduction The Parthenon Publishing Group, New York Moeloek F.A.et al eds., 351-354 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi M.et al.: Role of Inhibins and Activins in Reproduction. Molecular Basis of Reproductive Endocrinology Springer-Verlag, New York Leung P.C.K.et al eds., 50-62 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasegawa Y.et al.: Progress with Human and Rat Inhibon Characterization. Inhibin and Inhibin-Related Proteins Ares-Serono Symposia Publications, Rome Burger H.G.et al eds., 5-24 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakamura M.: "Effect of an activin A on FSH receotor messenger ribonucleic acid levels and FSH receptor expression in cultured rat granulosa cells" Endocrinology. 133. 538-544 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ito I.: "Developmental changes of activin and FSH receptor mRNA and plasma FSH and inhibin levels in rat tests." Life Science. 53. 1299-1307 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Minegishi T.: "Structure and regulation of LH/hCG receptor." Endocrine Journal. 40. 275-287 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shenker A.: "A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty." Nature. 365. 652-654 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hidaka A.: "Thyrotropin,like luteinizing hormone (LH) and chorionic gonado-tropin(CG),increase cAMP and inositol phosphate levels in cells with recombinant human LH/CG receptor." Biochem.Biophys.Res.Comm.196. 187-195 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Gunji K.: "Recombinant thyrotropin stimulates cAMP formatin in CHO-K1 cells expressing recombinant chorionic gonadotropin receptor." Biochem.Biophys.Res.Comm.197. 1530-1535 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nakamura K.: "Effect of activin on LH/hCG receptor messenger ribonucleic acid in granulosa cells." Endocrinology. 34. 2329-2335 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Minegishi T.: "Functional expression of the recombinant human FSH receptor." Journal of Endocrinology. 141. 369-375 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Igarashi S.: "Functional expression of recombinant human luteinizing hormone/human choriogonadotropin receptor." Biochem.Biophys.Res.Comm.201. 248-256 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hidaka A.: "Thyrotropin Stimulation of the Lutropin/Choriogonadotropin Recepto Different Sites Mediate Agonist Activity and High Affinity Binding" Thyroid. 4. 447-457 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hasegawa Y.: "Activin as Autocrine and Paracrine Factor in The Ovary." Horn.Res.41. 55-62 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kamijo T.: "In Vitro Fertilization of Androgen Sterilized Mice." Life Science. 55. 527-531 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tagagi T.: "Changes in Serum Immunoreactive Inhibin druing Ovulation Induction in Women with Amenorrea." Endocrine J.41. 703-708 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mizunuma H.: "Serum Immunoreactive Inhibin Levels in Polycystic Ovarian Disease (PCOD) and Hypogonadotropic Amenorrhea." Endocrine J.41. 409-414 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Minegishi T.: "Regulation of follicle-stumulating hormone receptor messenger ribonucleic acid levels in cultures rat granulosa cells." Molecular and Cellular Endocrinology. 108. 67-73 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tano M.: "Regulation of follistatin messenger ribonucleic acid in cultured rat granulosa cells." Molecular and Cellular Endocrinology. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] 峯岸敬: "ヒトLH/hCG,FSHレセプターの構造" 医学のあゆみ. 166. 762-762 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 石本一也: "ラット顆粒膜細胞のInhibin分泌に対するActivin AとラットFSHの分泌増強効果" 北関東医学. 43. 55-61 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 長谷川喜久: "インヒビン.アクチビン" 産婦人科の実際. 42. 1835-1839 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 中村和人: "LH/hCGの作用とレセプター" 産婦人科の実際. 42. 1811-1814 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 峯岸敬: "家族性思春期早発症とLH/hCGレセプター" Molecular Medicine. 31. 1208-1212 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Igarashi M.: "Role of Inhibins and Activins in Female Reproduction." Advances in Human Reproduction, The Parthenon Publishing Group. New York Moeloek F. A. et al eds., 4 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Igarashi M.: "Role of Inhibins and Activins in Reproduction" Molecular Basis of Reproductive Endocrinology Springer-Verlag, New York Leung P. C. K. et al eds., 13 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hasegawa Y.: "Progress with, Human and Rat Inhibin Characterization." Inhibin and Inhibin-Related Proteins Ares-Serono Symposia Publications, Rome Burger H. G. et al eds., 20 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 峯岸敬: "LH, hCG, FSHレセプター レセプター 井村祐夫, 他 編" 朝倉書店, 7 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 長谷川喜久: "下垂体前葉細胞の培養法 生殖機能細胞の培養法 菅原七郎,他 編" 学会出版センター, 10 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 五十嵐正雄: "lnhibin 産婦人科学書1 生殖医学 森宗英,他 編" 金原出版, 8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 長谷川喜久: "家畜繁殖 繁殖のホルモン 加藤征史郎 編" 朝倉書店, 14 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 長谷川喜久: "インヒビンとアクチビン 図説産婦人科13生殖と神経内分泌 加藤順三,他 編" メジカルビュー社, 11 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 中村 和人: "Effect of activin on LH/hCG receptor messenger ribonucler acid in granulosa cells" Endocrinology. (予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 峯岸 敬: "The functional expression of recombinent human follrle-stimulating hormane receptor" J of Endocrinol. (予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 峯岸 敬: "structwre and regulation of LH/hCG receptor" Endarine Journal. 40. 275-287 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 伊藤 郁朗: "Developmental changes of activin and FSH receptor mRNA and plasma FSH and inhibin in rat testes" Life Sciences. 53. 1299-1307 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中村 学: "Effect of an activin A on FSH receptor messenger ribonucler acid leves and FSH receptor txpression in culture rat granular cells" Endocrinology. 133. 538-544 (1993)

    • Related Report
      1993 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi