| Project/Area Number |
05454447
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KONISHI Ikuo Kyoto Univ, Faculty of Medicine, .Lecturer, 医学部, 講師 (90192062)
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| Co-Investigator(Kenkyū-buntansha) |
SAGAWA Norimasa Kyoto Univ, Faculty of Medicine, .Lecturer, 医学部, 講師 (00162321)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1994: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | Heat shock protein / HSP70 / HSP90 / Female genital tract / Endometrium / Endometrial cancer / Cervical cancer / Ovarian cancer |
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| Research Abstract |
Ovarian sex steroids are involved in growth and differentiation of normal and neoplastic cells in the female genital tract. Although heat shock proteins HSP70 and HSP90 are known to modulate the intracellular interaction between the sex steroid and the respective receptor protein, little is known about expression and localization of HSPs in the human female genital tract. This study revealed that both HSP70 and HSP90 are expressed and specifically localized in the cells of normal endometrium, myometrium, fallopian tube, and cervix. Expression level of HSP70 changes in endometrium and myometrium during the menstrual cycle.
Topological correlation between the HSPs and sex steroid receptors suggests that HSPs play an important role in the receptor-activation pathway in the endometrium. Endometrial hyperplasias/carcinomas and cervical carcinomas show an aberrant HSP70 expression. Ovarian cancers strongly express HSP70 along with p53 protein, which is inversely correlated with sex steroid receptor status. Consequently, both HSP70 and HSP90 are essential proteins in physiology and pathology of the female genital tract, and further studies are necessary to verify the exact function of these HSPs in the respective cells.
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