| Project/Area Number |
05454463
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Saga Medical School |
|---|
Principal Investigator |
TAKEMOTO Shin Saga Medical School, Faculty of Medicine, Professor, 医学部, 教授 (70080869)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUSE Toshiaki Saga Medical School, Faculty of Medicine, Research Associate, 医学部, 助手 (60244018)
MAEHARA Norifumi Saga Medical School, Faculty of Medicine, Research Associate, 医学部, 助手 (30199640)
UMEZAKI Toshiro Saga Medical School, Faculty of Medicine, Research Associate, 医学部, 助手 (80223600)
MAEYAMA Tadatsugu Saga Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (20145189)
WATANABE Hiroshi Saga Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50109394)
津田 邦良 佐賀医科大学, 医学部, 助手 (40207387)
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥4,100,000 (Direct Cost: ¥4,100,000)
|
|---|
| Keywords | protective reflex / swallowing / larynx / sensory resepor / nucleus tractus solitarius / swallowing related neurons / orbital gyrus / laryngeal sensory evoked potential / 喉頭 / 防御反射 / 嚥下反射 / 延髄 / 関連ニューロン / ニューロン活動 / パターン形成器 / 疑核 |
|---|
| Research Abstract |
The larynx participates in protective reflex during second stage of the swallowing. In this study, morphological and electrophysiological investigations were performed to clarify the neural organization of the swallowing in the cat.
The free nerve ending, taste buds and beaded nerve terminals were observed in the pharyngolaryngeal mucosa. It is proposed that mechanoreceptors, chemoreceptors and polymodal receoptors exist in the laryngeal mucosa. The strucures and characteristics of these receptors are appropriate for elicitation of the swallowing. The majority of the impulses from the pharyngolaryngeal region are carried into the interstitial subnucleus of the nucleus tractus solitarius. The sensory informations, which are essential for elicitaion of the protective reflex, are converged and processed in the interstitial subnucleus. The swallowing related neurons which burst during swallowing are classified into three types. A part of type II neurons constitute the central pattern generator for swallowing. The region of the cortex related to the swallowing was located in the orbital gyrus. This region may modulate the excitability in the elicitation of the swallowing. LSEP (laryngeal sensory evoked potential), which was consisted of short latent potentials in the brainstem and cortex evoked by electrical stimulation of the superior laryngeal nerve, was recorded from the scalp and generator sources were determined.
|
