| Project/Area Number |
05454478
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
UYAMA Masanobu Kansai Medical University, Professor, 医学部, 教授 (30025580)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kanji Kansai Medical University, Assistant Professor, 医学部, 講師 (60216710)
KISHIMOTO Naoko Kansai Medical University, Assistant Professor, 医学部, 講師 (10194838)
NISHIMURA Tetsuya Kansai Medical University, Associate Professor, 医学部, 講師 (30156111)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1993: ¥6,900,000 (Direct Cost: ¥6,900,000)
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| Keywords | Indocyanine green infrared fluorescence angiography / Fluorescence fundus angiography / Choroidal neovascularization / Choroidal circulatory disturbance / Choroidal infarction / Infrared fluorescence light microscopy / Retino-choroidal disease / 網膜脈絡膜病変 / ICG赤外蛍光眼底造影 / 網膜下新生血管 / レーザー光凝固 / インドシアニン・グリーン |
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| Research Abstract |
1. To read scientifically various findings by Indocyanine green (ICG) angiography, we did experimental work.
2. Proof of histological localization of ICG in the retina and choroid
In rats, intravenous by administered ICG particls were fixed in the retina and choroid, and demonstrated localization of ICG by infrared light microscope. ICG leaked through the choriocapillaris, then remained diffusely in the choroidal stroma. ICG did not move through the retinal vessels wall and also the retinal pigment epithelium (RPE).
3. ICG angiography in experimental choroidal infarction
In monkeys, the posterior ciliary arteries were cut on the surface of the sclera, and choroidal infarction were produced. ICG angiography, histopathological study and vascular cast preparation were done on these eyes. Early phase in ICG angiography was coresponded with choroidal circulatory disturbance, and late phase was masked with proliferated RPE.
4. ICG angiography in experimental choroidal neovascularization
In monkeys, choroidal neovascularization (CNV) were produced with intense laser photocoagulation on the posterior pole of the retina. ICG angiography, histopathological study, and vascular cast preparation were done on these eyes.
ICG angiography demonstrated CNV clearly. CNV were enclosed with proliferated RPE,then extravascular leakages were ceased in ICG angiography.
5. These results showed fundamentals on clinical interpretation of ICG angiography.
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