| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
This study was made to examine the pathogenesis and the therapeutic effects on desquamative gingival lesions originated in essentially dermatological diseases of 21 patients (male 2 and female 19, mean age : 47.3) . The chief complaints at first visit were various gingival pain, resulting in mental anxiety, and 70% of their complaints were gingival pain induced by local irritants. Seven of 19 female had past history of uterine myoma, and four of the seven cases underwent panhysterectomy. The primary lesions were characterized by zonal and/or spotted erythema and desquamation with occasional blistering of free and attached gingiva, and zonal lesions were mostly found at the buccalsites of upper molar and lower incisor regions. The diagnosis of chronic desquamative gingivitis was made by the clinical courses from onset of gingival signs. Histopathological examination and immunofluorescent technique of the lesions restricted to gingiva could not discover a specific basic disease, but clin
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ical signs of oral mucosa and skin lesions during observation periods were useful to make a diagnosis of basic disease. Finally, the patients were almost diagnosed as dermatological diseases such as inflammatory dyskeratosis (lichen planus) , bullous mucosal disease (pemphigus, pemphigoid and et at) and endocrine disorders. All patients were given mainly symptomatic treatment by topical medication. In addition, excision of diseased tissue, replacement with healthy gingiva, and systemic medication such as herb medicine, steroid and DDS were carried out. The therapeutic effect varied with the case. A healing was good in such cases as spotted erythema and pemphigus vulgaris, but was not good in erosive lichen planus. The primary desquamative gingival lesions mostly appeared as early onset of dermatological disease, but lesions restricted to gingiva were also observed in some cases. It seemed that a pathogenesis of the lesions could be related to hormonal disorder and mental stress, and further immunological research concerning factors regulating keratotic mechanism might be expected. Less
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