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Studies on microcirculation influences tissue activity of the Oral Mucousa in Diabetics

Research Project

Project/Area Number 05454547
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

KATAGIRI Sigeo  Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (70085752)

Co-Investigator(Kenkyū-buntansha) BABA Ryoko  Tokyo Dental College, Assistant., 歯学部, 助手 (20156540)
MORIMOTO Mitsuaki  Tokyo Dental College, Assistant., 歯学部, 助手 (90174458)
MIZUNO Yoshio  Tokyo Dental College, Professor., 歯学部, 教授 (40051750)
樋浦 秀一郎  東京歯科大学, 歯学部, 非常勤講師
秋谷 理  東京歯科大学, 歯学部, 非常勤講師
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥5,900,000 (Direct Cost: ¥5,900,000)
KeywordsDiabetics / Microangiopathy / Oral mucosa / Microcirculation / Vital Video-Microscopic System / Capi-Flow / PtO_2 / BrudU L.I. / 口腔粘膜微小循環 / 透過電顕
Research Abstract

In present study, we have attempted to clarify in the relationship between microcirculatory disturbance and tissue oxygon tension, cell kinetics of Oral mucosa in Diabetics. The results were as follows.
1 Significant findings of microcirculation were evidence of slow circulation, meandering in microvessels, irregularly vessel wall, abnormal architecturs and dicrease of visibility.
2 PtO2 levels in diabetics, 26.5(]SY.+-。[)9.5mmHg decreased significantly compared with that in control, 41.3(]SY.+-。[)3.7mmHg (p<0.01) .PtO2 levels correlated with HbA<@D21c@>D2 (r=-0.44p<0.01) and BrdU L.I.(r=0.53 p<0.01). Further, PtO2 levels correlated with abnormalities in microcirculation (r=-0.48 p<0.01) and progress of diabetic retinopathy (r=0.58 p<0.01).
3 PtO2 levels in insulin-treated diabetics were different in the individual patients. These data indicated PtO2 levels reflected the diabetic control and the influence of diabetic microangiopathy in oral mucosa.
4 Vital Video-microscopic system for observing the microcirculation, measurement of PtO2 levels, which is simple, noninvasive and valuable technique may be a useful predictor on the localization and progression at early stage of diabetic microangiopathy, further, these methods seemed to be very efficiant for futuer development of any complications with past-operative inflammation or relardation of wound healing in oral mucosa.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 森本光明: "糖尿病患者における口腔粘膜毛細血管生体ビデオ観察所見" 糖尿病. 36. 189- (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動体に関する研究-llbA_<1c>と組織酸素分圧(PtO_2)との関連-" 糖尿病. 37. 438- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森崎重規: "糖尿病患者口腔粘膜の毛細血管に関する研究-糖尿病性慢性合併症と血中トロンボモジュリン値-" 歯科学報. 11. 986- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森本光明: "糖尿病患者口腔粘膜における微小循環異常に関する研究" 第254回東京歯科大学学会(3月,千葉). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動体に関する研究-網膜症との関連について-" 第38回日本糖尿病学会年次学術集会(5月,大宮). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 片桐重雄: "Evalution of PtO_2 Measurement on the Oral Mucose in Diabetics." The IADR 73rd General Session (June, Singapore). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] MORIMOTO,M., etc.: "Vital Video-Microscopic System for obsarving the microcirculation of oral mucosa in Diabetics." J.Jap.Diab.Soc.36. 189 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] SUZUKI,Y., etc.: "A Study on cell kinetics of oral mucosa in Diabetics. - Correlation between HbA_<1c> and PtO_2" J.Jap.Diab.Soc.37. 438 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] MORIMOTO,M., etc.: "Studies on the oral mucosa vessels in Diabetics. -Correlation between the chronic complication of Diabetes and blood thrombomodulin-" The SHIKWA GAKUHO. 11. 986 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] MORIMOTO,M., etc.: "A Study on Abnormalities in Microcirculation of oral mucosa in Diabetics" The 254rd Tokyo Dental College Society (Chiba), March. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] SUZUKI,Y., etc.: "A Study on cell kinetics of oral mucosa in Diabetics. - Relationship with diabetic retinopaty -" The 38rd Japan Diabetes Society General session (Omiya), May. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] KATAGIRI,S., etc.: "Evalution of PtO_2 measurment on the oral mucosa in Diabetics." The IADR 73rd General session (Singapore), June. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動態に関する研究-HbA_1と組織酸素分圧(PtO_2)との関連-" 糖尿病. 37. 438- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 海州謙太郎: "糖尿病患者における血中微量金属元素と味覚障害について" 口腔診断学会雑誌. 7. 443- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森崎重規: "糖尿病患者口腔粘膜の毛細血管に関する研究-糖尿病性慢性合併症と血中トロンボモジュリン値-" 歯科学報. 11. 986- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森本光明: "糖尿病患者口腔粘膜における微小循環異常に関する研究" 第254回東京歯科大学学会(3月,千葉). 発表予定. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動態に関する研究-網膜症との関連について-" 第38回日本糖尿病学会年次学術集会(5月,大宮). 発表予定. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片桐重雄: "Evalution of PtO_2 Measurement on the Oral Mucosa in Diabetics." The IADR 73rd General Session(June,Singapore). 発表予定. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鈴木雄一: "糖尿病患者口腔粘膜における組織代謝と細胞動態に関する研究(第1報)" 歯科学報. 92. 1548- (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 片桐重雄: "糖尿病性慢性合併症と口腔診断" 日本口腔診断学会雑誌. 5. 585-587 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 杉原正哉: "ストレプトゾトシン糖尿病ラット茸状乳頭における毛細血管および末梢神経の電顕的観察" 歯科学報. 93. 609-630 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森本光明: "糖尿病患者における口腔粘膜毛細血管生体ビデオ観察所見" 糖尿病. 36. 189- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 海州謙太郎: "糖尿病性味覚障害に関する研究(第2報)" 歯科学報. 93. 1095-1096 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鈴木雄一: "糖尿病患者口腔粘膜上皮の細胞動態に関する研究" 糖尿病. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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