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Prediction of postpartum onset of autoimmune disease and its prevention

Research Project

Project/Area Number 05454584
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionOsaka University

Principal Investigator

AMINO Nobuyuki  Osaka University Medical School Department of Laboratory Medicine Professor, 医学部, 教授 (60028694)

Co-Investigator(Kenkyū-buntansha) YAGORO Aya  Osaka University Medical School Department of Laboratory Medicine Assistnant, 医学部, 助手 (60273653)
KASHIWAI Taku  Osaka University Medical School Department of Laboratory Medicine Assistant, 医学部, 助手 (00252685)
TADA Hisato  Osaka University Medical School Department of Laboratory Medicine Instructor, 医学部, 講師 (80263242)
HIDAKA Yoh  Osaka University Medical School Department of Laboratory Medicine Instructor, 医学部, 講師 (30243231)
玉置 治夫  大阪大学, 医学部, 助教授 (20221400)
光田 信明  大阪大学, 医学部, 助手 (50209805)
岩谷 良則  大阪大学, 医学部, 助教授 (60168581)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1993: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsAutoimmune desease / Hashimoto's thyroiditis / Graves' disease / Prediction of onset / Prevention / Pregnancy / Postpartum / Autoantibodies / 出産後発症 / 慢性関節リウマチ
Research Abstract

In order to predict the postpartum onset of various autoimmune diseases, we measured autoantibodies in early pregnancy and followed these positive women after delivery and tried to prevent postpartum onset or aggravation of autoimmune diseases. Obtain conclusions are :
1) Measurement of serum antibodies in normal subjects could detect subclinical form of autoimmune diseases, at least in the thyroid gland.
2) Seven kinds of autoantibodies were measured and anti-thyroid microsomal antibody was found in 15.4% of women, suggesting that the high incidence of subclincal autoimmune thyroid disease.
3) High tites (>20,000) of anti-thyroid microsomal antibody in early pregnancy was associated with postpartum onset of hypothyroidism, and destructive thyrotoxicosis was found before onset of hypothyroidism. Most hypothyroidism was transient but persistent one was found in one of 500 postpartum women.
4) Postpartum onser of Graves' disease could be predicted by measurement of microsomal antibody and then of thyroid stimulating antibody, and was found in one of 200 postpartum women.
5) For the prediction of postpartum onset of rheumatoid arthritis, measurement of rheumatoid factors were useful, but we need more specific antibodies to rheumatoid arthritis.
6) Small dose of steroid therapy started immediatedly after delivery for short duration was effective to prevent postpartum aggravation of autoimmune thyroid disease.
7) Postpartum onset of autoimmune disease was induced by immune rebound phenomenon after delivery.
Conclusion : Continuation of this study would be able to predict the onset of various autoimmune desease more perfectly and to reduce the number of patients with autoimmune disease.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Amino N et al.: "Gestaitional thyrotoxicosis and hyperemesis gravidarum : Possible role of hCG with higher stimulating activity." Clinical Endocrinology. 38. 345-350 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N et al.: "Intrathyroidal Iymphocyte subsets,including unusual CD4^+CD8^+ cells and CD3^<lo>TCR^<αβlo/>-CD4-CD8^- cells,in autoimmune thyroid disease." Clinical Exepta Immunology. 93. 430-436 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N et al.: "Crucial role of serum human chorionic gonadoropin for the aggravation of thyrotoxicosis in early pregnancy in Graves′ disease." Thyroid. 3. 189-193 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N et al.: "A case of postpartum hypopituitarism associated with empty sella : Possible relation to poatpartum autoimmune hypophysitis." Endocrine Journal. 40. 431-438 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N et al.: "Prevalence of postpartum onset of disease within patients with Graves′ disease of child-bearing age." Endocrine Journal. 41. 325-327 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N et al.: "Prediction of postpartum Graves′ thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy." Clinical Endocrinology. 41. 15-20 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N: "Thyroid Disease-Medical & Surgical Management" Chapman & Hall Ltd,London, 3 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Amino N,Tada H: "Endocrinology,3rd edition" W.B.Saunders Company,Philadelphia, 16 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kimura M,Amino N,Tamaki H,Ito E,Mitsuda N,Miyai K: "Gestational thyrotoxicosis and hyperemesis gravidarum : Possible role of hCG with higher stimulating activity." Clin Endocrinol. 38. 345-350 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishiyama S,Takada K,Tada H,Takano T,Amino N: "Effect of interleukin-6 on cell proliferation of FRTL-5 cells." Biochem Biophys Res Commun. 192. 319-323 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iwatani Y,Hidaka Y,Matsuzuka F,Kuma K,Amino N: "Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3^<lo>TCR^<ablo/>-CD4-CD8-cells, in autoimmune thyroid disease." Clin Exp Immunol. 93. 430-436 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tamaki H,Itoh E,Kaneda T,Asahi K,Mitsuda N,Tanizawa O,Amino N: "Crucial role of serum human chorionic gonadotropin for the aggravation of thyrotoxicosis in early pregnancy in Graves' disease." Thyroid. 3. 189-193 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishiyama S,Takano T,Hidaka Y,Takada K,Iwatani Y,Amino N: "A case of postpartum hypopituitarism associated with empty sella : Possible relation to postpartum autoimmune hypophysities." Endocrine Journal. 40. 431-438 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka Y,Amino N,Iwatani Y,Itoh E,Matsunaga M,Tamaki H: "Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease." J Clin Endocrinol Metab. 77. 1667-1670 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tada H,Hidaka Y,Itoh E,Kashiwai T,Tamaki H,Iwatani Y,Amino N: "Prevalence of postpartum onset of disease within patients with Graves' disease of child-bearing age." Endocine J. 41. 325-327 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka Y,Tada H,Kashiwai T,Sasaki S,Andoh S,Nakamura H,Amino N: "A case of hyperthyroidism due to pituitary resistance to thyroid hormone." Endocrine J. 41. 339-343 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidaka Y,Tamaki H,Iwatani Y,Tada H,Mitsuda N,Amino N: "Prediction of postpartum Graves' thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy." Clin Endocrinol. 41. 15-20 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tada H,Hidaka Y,Itoh E,Kashiwai T,Tamaki H,Iwatani Y,Amino N: "Prevalence of postpartum onset of disease within patients with Graves′disease of child‐bearing age." Endocrine J. 41. 325-327 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hidaka Y,T,Tamaki H,Iwatani Y,Tada H,Mitsuda N,Amino N: "Prediction of postpartum Graves′thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy." Clin Endocrinol. 41. 15-20 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hidaka Y,Nishi I,Tamaki H,Takeoka K,Tada H,Mitsuda N,Amino N: "Differentiation of postpartum thyrotoxicosis by serum thyroglobulin;Usefulness of the new multi-stie immunoradiometric assay." Thyroid. 4. 275-278 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tamaki H,Kaino M,Endo Y,Moriyama T,,Nakajima T Imagawa Y,Amino N: "Enzyme-linked immunosorbent assay for TSH receptor antibodies using the synthetic TSH receptor peptides." J Clin Lab Immunol. 43. 89-98 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsuruta E,Tada H,Tatsumi H,Kashiwai T,Asahi K,Takeoka K,Mitsuda N,Amino N: "Pathogenic role of asialo-hCG in gestational thyrotoxicosis." J Clin Endocrinol Metab. 80. 350-355 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Amino N,Tachi J: "Hypothyroidism:Aetiology and management(Chapter8)" Wheeler MH,Lazarus JH eds,Thyroid Disease-Medical & Surgical Management,Chapman & Hall Ltd,London,245-267 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Amino N,Tada H: "Autoimmune thyroid disease/Thyroiditis(Chapter43)" De Groot LJ ed,Endocrinology,3rd edition,W.B.Saunders Company,Philadelphia, 726-741 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kimudra M,Amino N,Tamaki H,Ito E,Mitsuda N,Miyai K: "Gestational thyrotoxicosis and hyperemesis gravidarum:Possible role of hCG with higherstimulating activity." Clin Endocrinol. 38. 345-350 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tamaki H,Itoh E,Kaneda T,Asahi K,Mitsuda N,Tanizawa O,Amino N: "Crucial role of serum human chorionic gonadotropin for the aggravation of thyrotoxicosis in early pregnancy in Graves' disease." Thyroid. 3. 189-193 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hidaka Y,Amino N,Iwatani Y,Itoh E,Matsunaga M,Tamaki H: "Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease." J Clin Endocrinol Metab. 77. 1677-1670 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tada H,Hidaka Y,Itoh E,Kashiwai T,Tamaki H,Iwatani Y,Amino N: "Prevalence of postpartum onset of disease within patients with Graves' disease of child-bearing age." Endocrine J. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Hidaka Y,Tamaki H,Iwatani Y,Tada H,Mitsuda N,Amino N: "Prediction of postpartum onset of Graves' thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy." Clin Endocrinol. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Hidaka Y,Nishi I,Tamaki H,Takeoka K,Tada H,Mitsuda N,Amino N: "Differntiation of Postpartum thyroitoxicosis by serum thyroglobulin;Usefulness of the new multi-site immunoradiometreic assay" Thyroid. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Amino N,Takada K: "In:Monaco F,Satta MA,Shapiro B,Troncone L eds.Thyroid Disease Vol.II Clinical Fundamentals and Therapy" Subacute Thyroiditis., 7 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Amino N: "In:Monaco F,Satta MA,Shapiro B,Troncone L eds.Thyroid Disease Vol.II Clinical Fundamentals and Therapy" Postpartum and Silent Thyroiditis, 11 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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