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Effects of dietary composition on colon carcinogenesis in the rats

Research Project

Project/Area Number 05454591
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 家政学
Research InstitutionDepartment of food and nutrition, Faculty of human life science, osaka city university

Principal Investigator

KATAYAMA Yohko  Osaka city university Prof., 生活科学部, 教授 (50047049)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kenichi  Osaka prefectural college of health science Prof., 医療技術短期大学部, 教授 (40089959)
OKUDA Toyoko  Osaka City University Associate Prof., 生活科学部, 助教授 (90047308)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordslactosucrose / pullulan / colon cancer / ornithin decarboxylase (ODC) / microflora / bile acids / rats / ラット / ビフィズス菌 / 胆汁酸 / ビタミンE(α-トコフェロール) / 運動 / 1,2-dimethylhydrazinc / 抗酸化酵素 / 1,2-Dimethylhydrazine / beta-glucuronidase / 結腸 / 盲腸
Research Abstract

In our results, rats fed the lactosucrose diet or pullulan diet demonstrated increases of Bifidobacterium in the cecum, a decrease of ornithine decarboxylase (ODC) activity in the colorectal mucosa, and a decrease of bile acid excretion into the feces. There are many kinds of effectors in the gastrointestinal tract, some of which might act on the colon to reduce the risk of colonc arcinogenesis in humans. The cecal contents are composed of various constituents, some of which may reduce or promote the risk carcinogenesis. Their metabolism is so complicated that it should be investigated in more detail.
In conclusion, the intestinal microflora composition, fecal bile acid and colorectal mucosal activity of ODC can be modified to reduce the incidence of colon carcinogenesis in DMH-treated rats fed the lactosucrose diet or pullulan diet for 35 weeks. Further investigation is needed to define the potential protective effect of lactosucrose or pullulan.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Jangmi Kang et al.: "Effects of 4^G-β-D-Galactosylsucrose on cecal microflora,bile acid composition and colonic mucosal ornithine decarboxylase activity-in the DMH-treated rats-" Digestion and Absorption. 17. 78-83 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuyuki Oku et al.: "Effects of pullulan on DMH-induced colon cartinoma in rats" Digestion and Absorption. 17. 84-89 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片山(須川)洋子ら: "高ペクチン食による小腸粘膜の形態的変化" 応用糖質科学. 41. 325-331 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 片山(須川)洋子ら: "水溶性食物繊維による盲腸内細菌叢の変化" 応用糖質科学. 41. 413-418 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Satoshi Sumida et al.: "Effects of Exercise Training and High Fat Diet on Antioxidant Status in Rats Treated with 1,2-Dimethylhydrazine" Adv.Exerc.Sports Physiol.1. 23-29 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jangmi Kang et al.: "Hypocholesterolemic effect of lactosucrose in the DMH-treated rat" Digestion and Absorption. 18. 74-79 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jangmi Kang, kazuyuki Oku, Akiko Kojima and Yohko Sugawa-Katayama: "Effects of 4^G-beta-D-Galactosylsucrose on Cecal Microflora and Bile Acids Composition, Colonic Mucosal Ornithine Decarboxylase Activity. -in the DMH-treated rats-" Digestion & Absortion. 17. 78-83 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuyuki Oku, Jangmi Kang, Akiko Kojima and Yohko Sugawa-Katayama: "Effects of Pullulan on DMH-induced Colon Carcinoma in Rats" Digestion & Absortion. 17. 84-89 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jangmi Kang, kazuyuki Oku and Yohko Sugawa-Katayama: "Hypocholesterolemic Effect of Lactosucrose in the DMH-treated Rats" Digestion & Absortion. 18. 74-79 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jangmi Kang et al.: "Effects of 4^G-β-D-Galactosylsucrose on cecal microflora,bile acid composition and colonic mucosal ornithine decarboxylase activity-in the DMH-treated rats-" Digestion and Absorption. 17. 78-83 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kazuyuki Oku et al.: "Effects of pullulan on DMH-induced colon cartinoma in rats" Digestion and Absorption. 17. 84-89 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 片山(須川)洋子ら: "高ペクチン食による小腸粘膜の形態的変化" 応用糖質科学. 41. 325-331 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 片山(須川)洋子ら: "水溶性食物繊維による盲腸内細菌叢の変化" 応用糖質科学. 41. 413-418 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Satoshi Sumida et al.: "Effects of Exercise Training and High Fat Diet on Antioxidant Status in Rats Treated with 1,2-Dimethlhydrazine" Adv.Exerc.Sports Physiol.1. 23-29 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Jagmi Kang et al.: "Hypocholesterolemic effect of lactosucrose in the DMH-treated rat" Digestion and Absorption. 18. 74-79 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Jangmi Kang et.al: "Effect of 4^G-β-D-galactosylsucrose on cccal microflora,bile acid composition and colonic mucosal ornithine carboxylase activity -In the DMH-treated rats-" Digestion and Absorption. 17. 78-83 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuyuki Oku et.al: "Effects of pullulan on DMH-induced colon carcinoman in rats" Digestion and Absorption. 17. 84-89 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片山(須川)洋子等: "水溶性食物繊維による盲腸内細菌叢の変化" 応用糖質科学. 41. 413-418 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片山(須川)洋子等: "高ペクチン食による小腸粘膜の形態的変化" 応用糖質科学. 41. 335-341 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 片山洋子(須川 洋子): "ラクトスクロースの発癌抑制効果" 日本消化吸収学会誌. 17. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小島明子,片山(須川)洋子: "1,2-dimethylhydrazine誘発大腸癌の発生におよぼすラクトスクロースの抑制効果" 日本消化吸収学会誌. 16. 124-127 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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