| Project/Area Number |
05454676
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Jichi Medical School |
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Principal Investigator |
NAGAO Soichi Faculty of Madicine, Jichi Medical School, Associate Professor., 医学部, 助教授 (40164397)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | cerebellum / vestibulo-ocular reflex / smooth pursuit eye movement / primate / control / flocculus / paraflocculus / サッケオード眼球運動 / 随意運動 / 適応 / 学習制御 / 霊長類 / 小脳核 / サッケード眼球運動 / 運動制御 / ニューロン / 神経回路網 |
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| Research Abstract |
The neural mechanisms for the short-term adaptation of the vestibulo-ocular reflex (VOR) has been investigated as an experimental model of the cerebellar motor control. My results of lesion, single unit recording and circuitry analysis studies in the rabbit and monkey experiments consistently support the hypothesis that the flocculus adaptively controls the gain of the VOR through the long-term depression (LTD) of transmission efficacy of the synapses on the Purkinje cells within the flocculus. To this flocculus hypothesis, a different role of the flocculus is proposed in the monkey VOR that the adaptation of the VOR is induced by the cooperation of the flocculus and its target neurons in the brain stem (Lisberger and Sejnowski 1993). To this proposal, however, my neuroanatomical study using retrograde and/or anterograde axonal flow methods and study of unit recording experiments reveal that the caudal half of the monkey flocculus has the characteristics for the control of the VOR,but the rostral half of it has the characteristics for the control of smooth pursuit. So I suggest that the rostral half of the monkey flocculus belongs to the ventral paraflocculus. The experimental observations reported by the Lisberger's group seem to include thoses obtained in the ventral paraflocculus. Therefore, I suggest that the flocculus and ventral paraflocculus respectively controls the vestibulo-ocular and smooth pursuit eye movements in the primate. My behavioral study using the adaptation of the primate VOR and those for the adaptation smooth pursuit eye movements also support the view that these two slow eye movements are independently controlled by the different groups of neurons in the cerebellum.
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