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Novel Surface Processing for Artificial, Cellular and Biomolecular Devices

Research Project

Project/Area Number 05454695
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MATSUDA Tkehisa  Nat'l Cardiovasc.Ctr.Res.Inst., Dept.of Bioengineering, Head, 生体工学部, 部長 (60142189)

Co-Investigator(Kenkyū-buntansha) TAKAICHI Shigeko  Nat'l Cardiovasc.Ctr.Res.Inst., Dept.of Etiol.and Pathogen., Researcher, 病因部, 室員 (00093930)
NAKATANI Takeshi  Nat'l Cardiovasc.Ctr.Res.Inst., Dept.of Bioengineering, Researcher, 生体工学部, 室長 (60155752)
SEKI Junji  Nat'l Cardiovasc.Ctr.Res.Inst., Dept.of Bioengineering, Researcher, 生体工学部, 室長 (20163082)
NAKAYAMA Yasuhide  Nat'l Cardiovasc.Ctr.Res.Inst., Dept.of Bioengineering, Researcher, 生体工学部, 室員 (50250262)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1994: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywordsmicroarchitectural desigh / submicron device / artificial organ / micromachine
Research Abstract

This study was conducted to complete this three-years project. Elemental materials and processes based on photochemical reactions were explored and realized (1) to modify fabricated devices to provide a desired biocompatibility at a given portion of devices and (2) to provide surface functionalities of microprocessed biosensors. These UV-and pulsed UV-based microprocess surface technologies would serve as fundamental research processing for advanced artificial organs and micromachines.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Y.NAKAYAMA,T.MATSUDA: "NOVEL SURFACE FIXATION TECHNOLOGY OF HYDROGEL BASED ON PHOTOCHEMICAL METHOD:HEPARIN-IMMOBILIZED HYDROGELATED SURFACE." J POLYM SCI:POLYM CHEM. 31. 977-982 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松田 武久: "表面設計と細胞接着制御" 組織培養. 19. 536-542 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.NAKAYAMA,T.MATSUDA: "SURFACE FIXATION OF POLY(ETHYLENE CTLYCOL)VIA PHOTO DIMERIZATION OF CINNAMATE CTROUP" J POLYM SCI : POLYM CHEM. 31. 3299-3305 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.MATSUDA,D.J.CHUNG: "MICROFABRICATED SURFACE DESIGNS FOR CELL CULTURE AND DIAGNOSIS." ASAIO JOURNAL. 40. M594-597 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松田 武久: "細胞行動形態を操作する人工基材の表面設計(I):細胞接着・組織化過程の細胞バイオメカニクス" 生体材料. 12. 187-195 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松田 武久: "細胞行動形態を操作する人工基材の表面設計(II):細胞組織形態の多様性とモデル表面作製" 生体材料. 12. 232-243 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.MATSUDA: "ARTIFICIAL HEART-4" SPRINGER-VERLAG, 423 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松田 武久: "アテネの学堂" ジャストシステム, 302 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nakayama, T.Matsuda: "Novel Surface Fixation Technology of Hydrogel Based on Photochemical Method : Heparin-Immobilized Hydrogelated Surface" J Polym Sci : Polym Chem. 31. 977-982 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kito, N.Nakajima, T.Matsuda: "Differentiated Biocompatible Design of Luminal and Outer Graft Surfaces : Photocurable Extracellular Matrices, Fabrication and Cellular Responses" ASAIO Joumal. Vol.39 (3). M506-M511 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nakayama, T.Matsuda, M.Irie: "Novel Surface Photo-Graft Polymerization Method for Fabricated Devices" ASAIO Journal. Vol.39 (3). M542-M544 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nakayama, T.Matsuda: "Photo Induced Surface Heparin Immobilization" ASAIO Journal. Vol.39 (3). M754-M757 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nakayama, T.Matsuda: "Surface Fixation of Poly (ethylene glycol) via Photodimerization of Cinnamate Group" J Polym Sci Part A : Polym Chem. Vol.31. 3299-3305 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Matsuda, D.J.Chung: "Microfabricated Surface Designs for Cell Culture and Diagnosis" ASAIO Journal. Vol.40 (3). M594-597 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nakayama, T.Matsuda: "Microporous Polymer Surfaces Prepared by Excimer Laser Ablation Technique" ASAIO Journal. Vol.40 (3). M590-593 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kito, F.Suzuki, S.Nagahara, Y.Nakayama, Y.Tsutsui, N.Tsutsui, N.Nakajima and T.Matsuda: "A Total Delivery System of Genetically-engineered Drug and Cell for Diseased Vessels : Concept, Materials and Fabricated Prototype Device" ASAIO Journal. 40 (3). M260-266 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松田 武久: "細胞行動形態を操作する人工基材の表面設計(I):細胞接着・組織化過程の細胞バイオメカニクス" 生体材料. 12. 187-195 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 松田 武久: "細胞行動形態を操作する人工基材の表面設計(II):細胞・組織形態の多様性とモデル表面作製" 生体材料. 12. 232-243 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Matsuda and D.J.Chung: "Microfabricated Surface Designs for Cell Culture and Diagnosis" ASAIO Journal. 40. M594-M597 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Nakayama and T.Matsuda: "Microporous Polymer Surfaces Prepared by Excimer Laser Ablation Technique" ASAIO Journal. 40. M590-M593 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 菅原隆、松田武久: "光反応性高分子による材料表面の極微細修飾と細胞の接着、遊走制御" 人工臓器. 22. 407-411 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中山泰秀、松田武久: "新しいハイドロゲル固定化法を用いたデバイス表面への抗血栓性の付与" 人工臓器. 22. 394-397 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.NAKAO,T.MATSUDA ET.AL.: "DESIGN CONCEPT AND CONSTRUCTION OF A HYBRID LAMELLAR KERATOPROSTHESIS" ASAIO JOURNAL. 39. 257-260 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.MIWA,T.MATSUDA ET AL.: "DEVELOPMENT OF A HIERARCHICALLY STRUCTURED HYBRID VASCULAR CTRAFT BIOHIHICKING NATURAL ARTERLES" ASAIO JOURNAL. 39. 273-277 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.KITO,N.NAKAJIMA,T.MATSUDA: "DIFFERENTIATED BIOCOMPATIBLE DESIGN OF LUMINAL AND OUTER GRAFT SURFACES" ASAIO JOURNAL. 39. 506-511 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] TAKEHISA MATSUDA: "ARTIFICIAL HEART 4" SPRINGER-VERLAG(TOKYO), 423 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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