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Significances of urinary levels of ulinastatin in the diagnosis of dementia

Research Project

Project/Area Number 05455013
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionShimane Medical University

Principal Investigator

TAKAORI Shuji  Shimane Medical University, President, 学長 (10025538)

Co-Investigator(Kenkyū-buntansha) SHIKIMI Tadahiro  Shimane Med.Univ., School of Med., Associate Professor, 医学部, 助教授 (00065913)
HATTORI Keisuke  Shimane Med.Univ., School of Med., Professor, 医学部, 教授 (80112134)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1993: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsUlinastatin / alpha1-Microglobulin / Alzheimer-type senile dementia / Vascular dementia / Human urine / パーキンソン氏病 / 精神分裂病 / 気分障害患者
Research Abstract

Relationships between urinary levels of alpha1-microglobulin (alpha1M) and ulinastatin (UT) in patients with dementia were investigated. There were no significant differences in alpha1M and UT levels and alpha1M/UT ratios among three groups : age-matched control subjects, patients with either Alzheimer-type senile dementia (ATD) and vascular dementia (VD). Although a positive correlation was established between alpha1M and UT levels in these groups, the regression slope of demented patients differed significantly from that of controls (P<0.05). A tendency toward a negative correlation between alpha1M/UT ratios and the scores of severity, or duration, of the disease was displayd in the ATD group, whereas a tendency toward a positive correlation between alpha1M/UT ratios and the scores of severity was observed in the VD group. In ATD patients, lower scores of severity were observed, where a lower alpha1M levels were registered. These results suggest that changes in the alpha1M levels and the relationships between urinary levels of alpha1M and UT may provide a useful biochemical index for the diagnosis of dementia.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Momiyama,T.: "Enhancement of D2 receptor agonist-induced inhibition by D1 receptor agonist in the ventral tegmental area" Br.J.Pharmacol.110. 713-718 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishihara,K.: "Abnormal excitability of hippocampal CA3 pyramidal neurons of spontaneously epileptic rats(SER),a double mutant" Exp.Neurol.119. 287-290 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi,T.: "Relationships between urinary levels of ulinastatin and α1-microglobulin and the severity of Alzheimer-type or vascular dementia" Jpn.J.Clin.Pharmacol.Ther.24. 571-577 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi,T.: "Relationships between ulinastatin and alpha-1-microglobulin in human urine" Clin.Chim.Acta. 227. 195-200 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shimada,Y.: "A well-controlled study of Choto-san and placebo in the treatment of vascular dementia" J.Tradit.Med.11. 246-255 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Inagaki,T.: "Changes in the ratio of urinary α1-microglobulin to ulinastatin levels in patients with dementia" Jpn.J.Psychiat.Neurol.(submitted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Momiyama T: "Enhancement of D2 receptor agonist-induced inhibition by D1 receptor agonist in the ventral tegmental area." Br.J.Pharmacol.110 (3). 713-718 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishihara K: "Abnormal excitability of hippocampal CA3 pyramidal neurons of spontaneously epileptic rats (SER), a double mutant." Exp.Neurol.119 (2). 287-290 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi T: "Relationships between urinary levels of ulinastatin and alpha1-microglobulin and the severity of Alzheimer-type or vascular dementia." Jpn.J.Clin.Pharmacol.Ther.24 (4). 571-577 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi T: "Relationships between ulinastatin and alpha-1-microglobulin in human urine." Clin.Chim.Acta. 227 (2). 195-200 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shimada Y: "A well-controlled study of Choto-san and placebo in the treatment of vascular dementia." J.Tradit.Med.11 (4). 246-255 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Inagaki T: "Changes in the ratio of urinary alpha1-microglobulin to ulinastatin levels in patients with dementia" Jpn.J.Psychiat.Neurol.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi,T.: "Relationships between ulinastatin and alpha-1-microglobulin in human urine" Clin.Chim.Acta. 227. 195-200 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shimada,Y.: "A well-controlled study of Choto-san and placebo in the treatment of vascular dementia" J.Tradit.Med.11. 246-255 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shikimi,T.: "Effects of glutamate agonists and ischemia on human urinary trypsin inhibitor(ulinastatin)-like substance in the murine brain" Canad.J.Physiol.Pharmacol.72,Suppl.1. 334- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shikimi,T.: "Relationships of ulinastatin and alpha-1-microglobulin contents in urine and cerebrospinal fluids with dementia" Pathophysiology. 1,Suppl.1. 448- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Inagaki,T.: "Relationship between urinary levels of ulinastatin and α1-microglobulin in patients with various neuropsychiatric diseases" Jpn.J.Pharmacol.67,Suppl.1. 164- (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 食見 忠弘: "脳脊髄液中に認められるウリナスタチン抗体陽性物質について" 日薬理誌. 105. 88- (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shikimi,T.: "Relationships between urinary levels of ulinastatin and α1-microglobulin and the severity of Alzheimer-type or vascular dementia" Jpn J Clin Pharmacol Ther. 24. 571-577 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shikimi,T.: "Effects of heparin on the inhibitory activities of human urinary trypsin inhibitor(ulinastatin)on trypsin,chymotrypsin and leukocyte elastase" Jpn J Pharmacol. 62. 115-118 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shikimi,T.: "Demonstration of a human urinary trypsin inhibitor(urinastatin)-like substance in the murine brain" Brain Research. 616. 230-235 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tamura,Y.: "Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons" J Pharmacol Exp Ther. 265. 1017-1025 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Momiyama,T.: "Enhancement of D2 receptor agonist-induced inhibition by D1 receptor agonist in the ventral tegmental area" Br J Pharmacol. 110. 713-718 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ishihara,K.: "Abnormal excitability of hippocampal CA3 pyramidal neurons of spontaneously epileptic rats(SER),a double mutant" Exp Neurol. 119. 287-290 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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