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"Development of system for diagnosis of early-stage arteriosclerosis using ultrasound"

Research Project

Project/Area Number 05555108
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 計測・制御工学
Research InstitutionFaculty of Engineering, Tohoku University

Principal Investigator

CHUBACHI Noriyoshi  Tohoku University, Faculty of Engineering, Professor, 工学部, 教授 (20006224)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Yasuhito  GE Yokogawa Medical Systems Co.Ltd., Head Manager, 研究開発部, 研究開発課長
SUZUKI Hideo  Ono Sokki Co.Ltd., Acoustic Lab., Head Manager, 音響技術研究所, 研究開発部長
KOIWA Yoshiro  Tohoku University, School of Medicine, Assoc.Professor, 医学部, 助教授 (80091685)
TANAKA Motonao  Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (40006094)
KANAI Hiroshi  Tohoku University, Faculty of Engineering, Assoc.Professor, 工学部, 助教授 (10185895)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥10,900,000 (Direct Cost: ¥10,900,000)
Fiscal Year 1994: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1993: ¥6,400,000 (Direct Cost: ¥6,400,000)
Keywordsatherosclerosis / local elastic characteristics / ultrasonic measurements / non-invasive measurement / ultrasonic Doppler method / pulse wave velocity / small vibration measurements / early-stage diagnosis of arteriosclerosis / 脈波伝搬特性 / 弾性特性 / スペクトル解析 / 早期診断
Research Abstract

In this research, we have developed a new method to measure local pulse wave velocity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i.e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.
Therefore, we have developed a new system to noninvasively measure small vibration signals on the heart wall or the aortic wall from the surface of the skin based on the ultrasonic Doppler effect. … More By this system, small vibrations with amplitudes of 10 - 100 mum on the motion due to heart beat with the large amplitude of 10 mm are successfully detected in the frequency range up to 1 kHz continuously for more than ten beat periods from the chest.
This research also developed a new method for obtaining local PWV by simultaneously measuring small vibrations at two points on the surface of the tube wall and the aortic wall. By the developed method, high spatial resolution, which is necessary in the evaluation of local hardness, is attained. By comparing the static experiments and dynamic experiments using a silicon tube, it is confirmed that the local hardness (Young's modulus) of the vessel wall is also evaluated with high spatial resolution.
By applying the developed system and the method to in vivo experiments, the PWV of the vibration wave transmitted between the two points on the aortic wall is obtained even for the aortic wall near the aortic valve. The distance between the two points is about several millimeters. The local elasticity (Young's modulus) is also evaluated for each measurement point. Thus, the developed system will be effective for local evaluation of the hardness on the aortic wall. Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] H.Kanai,K.Kawabe,M.Takano,R.Murata,N.Chubachi,Y.Koiwa: "New Method for Evaluating Local Pulse Wave Velocity by Measuring Vibrations on Arterial Wall" IEE Electronics Letters. 30. 534-536 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kanai,T.Hori,N.Chubachi,T.Ono: "Delayed Block Transfer Function and its Application to Accurate Es-timation of Transfer Function" IEEE Transctions on Signal Processing. 41. 1669-1684 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 村田亮治、金井 浩、中鉢憲賢、小岩喜郎、竹内康人: "動脈硬化の非侵襲的診断を目指した超音波ビームの制御による動脈壁上2点での微小振動の計測" 日本超音波医学会誌. 21. 703-711 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 川辺健一、村田亮治、金井 浩、中鉢憲賢、小岩喜郎: "動脈硬化の診断を目指した壁の微小振動検出によるヒトのin vivoでの動脈壁局所的脈波速度の測定" 日本音響学会誌. 51. 111-116 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐藤宏明、金井 浩、中鉢憲賢、小岩喜郎: "心臓疾患の非侵襲的診断を目指した超音波ドプラによる心臓壁微小振動の解析" 日本超音波医学会誌. 22. 印刷中 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高野正彦、金井 浩、中鉢憲賢、小岩喜郎、手塚文明、高橋光浩: "動脈硬化の局所診断のための血管壁上微小振動の計測と解析" 日本音響学会誌. 51. 174-181 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ken'ichi Kawabe, Hiroshi Kanai, and Noriyoshi Chubachi: ""Accuracy Evaluation in Ultrasonic-Doppler-Based Measurement of Small Vibrations for Acoustical Diagnosis of the Aortic Wall"" Electronics Letters. Vol.29, No.10. 915-916 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hiroshi Kanai, Toyohiro Hori, Noriyoshi Chubachi, and Takahiko Ono: ""Delayd Block Transfer Function and its Application to Accurate Estimation of Transfer Function"" IEEE Transactions on Signal Processing. Vol.41, No.7. 1669-1684 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ryoji Murata, Hiroshi Kanai, Noriyoshi Chubachi, Yoshiro Koiwa, Yasuhito Takeuchi: ""Measurement of Small Vibrations at Two Adjacent Points on the Aorta by Controlling the Direction of an Ultrasonic Beam for Noninvasive Diagnosis of Arteriosclerosis"" Japanese Journal of Medical Ultrasonics. Vol.21, No.11. 703-711 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ken'iti Kawabe, Ryoji Murata, Hiroshi Kanai, Noriyoshi Chubachi, Yoshiro Koiwa: ""In vivo measurment of local pulse wave velocity on arterial wall of human being by detecting small vibrations for diagnosis of atherosclerosis"" The Journal of the Acoustical Society of Japan. Vol.51, No.2. 111-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hiroaki Sato, Hiroshi Kanai, Noriyoshi Chubachi, Yoshiro Koiwa: ""Analysis of Small Vibrations on the Heart Wall Measured by Ultrasonic Doppler dor Noninvasive DIagnosis of Cardiac Muscle Dysfunction"" Japanese Journal of Medical Ultrasonics. Vol.22, No.2. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masahiko Takano, Hiroshi Kanai, Noriyoshi Chubachi, Yoshiro Koiwa, Fumiaki Teduka, Mituhiro Takahashi: ""Measurement and analysis of small vibrations on local aortic wall for diagnosis of arteriosclerosis"" The Journal of the Acoustical Society of Japan. vol.51, No.3. 174-181 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kanai,K.Kawabe,M.Takano,R.Murata,N.Chubachi,Y.Koiwa: "New Method for Evaluating Local Pulse Wave Velocity by Measuring Vibrations on Arterial Wall" IEE Electronics Letters. 30. 534-536 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Kanai,T.Hori,N.Chubachi,T.Ono: "Delayed Block Transfer Function and its Application to Accurate Estimation of Transfer Function" IEEE Transactions on Signal Processing. 41. 1669-1684 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 村田亮治,金井 浩,中鉢憲賢,小岩喜郎,竹内康人: "動脈硬化の非侵襲的診断を目指した超音波ビームの制御による動脈壁上2点での微小振動の計測" 日本超音波医学会誌. 21. 703-711 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川辺健一,村田亮治,金井 浩,中鉢憲賢,小岩喜郎: "動脈硬化の診断を目指した壁の微小振動検出によるヒトのin vivoでの動脈壁局所的脈波速度の測定" 日本音響学会誌. 51. 111-116 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤宏明,金井 浩,中鉢憲賢,小岩喜郎: "心臓疾患の非侵襲的診断を目指した超音波ドプラによる心臓壁微小振動の解析" 日本超音波医学会誌. 22(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高野正彦,金井 浩,中鉢憲賢,小岩喜郎,手塚文明,高橋光浩: "動脈硬化の局所診断のための血管壁上微小振動の計測と解析" 日本音響学会誌. 51. 174-181 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kawabe,H.Kanai,N.Chubachi: "“Accuracy Evaluation in Ultrasonic-Doppler-Based Measurement of Small Vibrations for Acoustical Diagnosis of the Aortic Wall"" Electronics Letters. 29. 915-916 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 金井浩,中鉢憲賢: "“低いSN比の下での離散的フーリエ変換による周波数分析における偏り誤差と分散の理論解析"" 日本音響学会誌. 49. 763-774 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Kanai,H.Satoh,K.Hirose,N.Chubachi: "“A New Method for Measuring Small Local Vibrations in the Heart Using Ultrasound"" IEEE Transactions on Biomedical Engineering.40. 1233-1242 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤宏明,金井浩,中鉢憲賢: "“ダイナミックプログラミングを用いた心臓壁面運動のトラッキングによる心臓壁の微小な振動計測"" 日本音響学会誌. 50. 11-21 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 朴茂薫,金井浩,中鉢憲賢: "“超音波ドプラ法による加振時の骨の曲げ振動伝搬速度の計測"" 日本音響学会誌. 50. 103-109 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Kanai,T.Hori,N.Chubachi,T.Ono: "“Delayed Block Transfer Function and its Application to Accurate Estimation of Transfer Function"" IEEE Transactions on Signal Processing. 41(発表予定). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2021-09-01  

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