| Project/Area Number |
05555115
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
計測・制御工学
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| Research Institution | Yatushiro National College of Technology |
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Principal Investigator |
YAMASAKI Masaki Yatushiro National College of Tecnology, Department of Bioengineering, Professor, 生物工学科, 教授 (80040286)
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Hidetoshi Panafarm Laboratories Co., Computaer Programing Section, Reseach Worker, 研究開発部電算機室, 研究員
IWASAKI Minoru Panafarm Laboratories Co., Computaer Programing Section, Reseach Worker, 研究開発部電算機室, 研究員
HONDA Itsuo Kumamoto Hospital of Orthopaedic surgery, Head of Research Divition, 研究部長
SOU Meisho Nagata Hospital of Orthopaedic Surgery, Head of Research Divition, 研究部長
松浦 周介 八代高専, 生物工学科, 助教授 (20143943)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | Synovial Fluid / Rheumatoid Arthritis / Osteoarthritis / Chemotherapy / Malignancy Index / NMR / Relaxation Time / Software / Malignancy Index |
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| Research Abstract |
Application of the nuclear magnetic resonance (NMR) method has been attemted in the medical field as a new diagnostic technique.
In this research, we have systematically studied the NMR relaxatin times (T_1 and T_2) of water protons in the synovial fluid of human Rheumatoid Arthritis and Osteoarthritis.
Using the values of the malignancy index derived from the relaxation times (T_1 and T_2) of these disease, it has been possible to discriminate clearly between Rheumatoid Arthritis and Osteoarthritis, and also to evaluate the effectiveness of chemotherapy in these arthritis disease.
The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in these disease.
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