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Development of bio-science materials by designing porous structure and surface property of oxide gels.

Research Project

Project/Area Number 05555170
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Inorganic materials/Physical properties
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SOGA Naohiro  Kyoto University, Faculty of Engineering, Professor, 工学部, 教授 (80026179)

Co-Investigator(Kenkyū-buntansha) IMADA Kiyohisa  Miyazaki University, Faculty of Engineering, Professor, 工学部, 教授 (00037748)
NAKANISHI Kazuki  Kyoto Univ., Faculty of Eng.Research Associate, 工学部, 助手 (00188989)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 1994: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1993: ¥7,600,000 (Direct Cost: ¥7,600,000)
KeywordsSol-gel Method / Silica / Phase Separation / Pore Structure / Surface Modification / Separation Function / Artificial Bone / Porous Material / クロマトグラフィー
Research Abstract

Silica gels with controlled interconnected pores in micrometer range have been prepared by hydrolyzing alkoxysilane in the presence of a certain kind of water-soluble polymer using acetic acid as a catalyst. The time-resolved laser light scattering measurements of gelling solution revealed that the interconnected structure is developed when the phase separation by the spinodal mechanism and the sol-gel transition take place almost concurrently. The soaking of gels, prior to the evaporation of the solvent, in ammonia solutions with various concentration and volume ratio to the gel piece at various temperatures resulted in the modification of nanometer range pore structures into well-defined mesopores up to 20nm in diameter, after appropriate drying and heat-treatment. The higher the ammonia concentration, and the higher the soaking temperature, the larger the pore size became. When the soaking was carried out with smaller volume of solvent against a gel piece, the structural change was retarded. This result indicates that the dissolution of silica from the wet gel surface into the external solvent is the rate determining step of the whole structure evolution due to dissolution and re-precipitation of silica. The soaking treatment could completely eliminate the micropores in the gel specimen. An evaluation of silica monoliths having double pore sturcures thus prepared was carried out as a chromatographic column material. After chemical modification of hydrophilic silica gel surface with octadecyl and methyl ligands, a rod shaped monolith was clad with polymer, and was equipped to an LC apparatus. The separation factors for alkylbenzens of the monolithic column was almost the same as that of conventional packed beads column, however, the applied pressure for the same sample flow rate was reduced to 1/2 to 1/3 of conventional one.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report

Research Products

(23 results)

All Other

All Publications (23 results)

  • [Publications] N. Soga: "Syntnesis and structure control of inorganic porous gels by the polymer-incorporated sol-gel method" New Functional Materials. 685-690 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Nakanisni: "Macropore strusture design of sol-gel derived silica by spinodal decomposition" Ceramic Transactions “Porous Materials". 31. 51-60 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Nakanisni: "Phase separation in silica sol-gel system containing poly( ethylene oxide). I. Phase relation and gel morphology" Bulletin of Chemical Society of Japan. 67. 1327-1335 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Nakanisni: "Phase separation Kinetics in silica sol-gel system containing polyethylene oxide I. Initial Stage" Journal of Sol-Gel Science and Technology. 2. 227-231 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Imada: "Application of porous glass as Merrifield type suppot" New Functional Materials. 595-600 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S. Hayashi: "Immobilization of beta-fructofuranosidase from Aureobasidium on DEAE-cellulose" Journal of Industrial Microbiology. 13. 103-105 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Soga et al.: "Synthesis and structure control of inorganic porous gels by the polymer-incorporated sol-gel method" "New Functionality Materials, vol.C" , Elsevier Science Publishers B.V., Amsterdam. 685-690 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakanishi et al.: "Macropore structure design of sol-gel derived silica by spinodal decomposition" Ceramic Transactions 31, "Porous Materials" , eds K.Ishizaki et al.51-60 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakanishi et al.: "Phase separation in Silica Sol-Gel System Containing Poly (ethylene oxide) . I.Phase Relation and Gel Morphology" Bull.Chem.Soc.Jpn.67. 1327-1335 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] P.Li et al.: "The role of hydrated silica, titania, and alumina in inducing apatite on implants" J.Biomed.Mat.Res.28. 7-15 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Kokubo et al.: "Dependence of Bone-like Apatite Formation on Structure of Silica Gel" Bioceramics. 7. 49-54 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakanishi et al.: "Phase separation kinetics in silica sol-gel system containing polyethylene oxide I.Initial Stage" J.Sol-Gel Sci.Tech.2. 227-231 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kaji et al.: "In situ observation of phase separation processes in gelling alkoxy-derived silica system by light scatterig method" J.Sol-Gel Sci.Tech.3. 169-187 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kaji et al.: "Formation of porous gel morphology by phase separation in gelling alkoxy-derived silica. Affinity between silica polymers and solvent" J.Non-Cryst.Solids. 181. 16-26 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Imada: "Applications of porous glass as Merrifield type support" "New Functionality Materials, vol.C" , Elsevier Science Publishers B.V., Amsterdam. 595-600 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Hayashi et al.: "Immobilization of beta-fructofuranosidase from Aureobasidium on DEAE-cellulose" J.Industrial Microbiology. 13. 103-105 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Hayashi et al.: "The enzymatic reaction for the production of panose and isomaltose by glucosyltransferase from Aureobasidium" Letters in Appl.Microbiology. 19. 247-248 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Hayashi et al.: "The effect of chemicals on the activity of deglycosylated Aureobasidium beta-fructofuranosidases" Letters in Appl.Microbiology. 18. 105-106 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Hayashi et al.: "Purification and properties of glucosyltransferase from Aureobasidium" J.Industrial Microbiology. 13. 5-9 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Hayashi et al.: "Long-term continuous reaction of immobilized beta-fructofuranosidase" Biotechnology Letters. 16. 227-228 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakanishi: "Phase separation kinetics in silica sol-gel system containing polyethylene oxide I.Initial Stage" Journal of Sol-Gel Science and Technology. 2. 227-231 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Nakanishi: "Phase separation in silica sol-gel system containing poly(ethylene oxide)I.Phase relation and gel morphology" Bulletin of Chemical Society of Japan. 67. 1327-1335 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuki NAKANISHI: "Phase Separation in Silica Sol-Gel System Containing Poly(ethyleneoxide).I.Phase Relation and Gel Morphology" Bulletin of Chemical Society of Japan. 67(印刷中). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-03-31   Modified: 2016-04-21  

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