| Project/Area Number |
05556020
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
食品科学・栄養科学
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| Research Institution | Nagoya University BioScience Center |
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Principal Investigator |
NAKANO Kiwao Nagoya University BioScience Center Assoc. Professor, 生物分子応答研究センター, 助教授 (10023433)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Shoei Gifu Pharmaceutical University Dept. of Pharmacology, Assoc.Prof., 薬学部, 助教授 (90159129)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 1994: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1993: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Nerve growth factor / Tryptophan. / Kynurenine / アストロサイト / アルツハイマー症 / アストログリア細胞 |
|---|
| Research Abstract |
Effects of various amino acids and secondery metabolites of vegetable foods were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. L-tryptophan stimulated NGF production in a dosedependent manner. Serotonin and quinolinic acid slightly increased NGF synthesis. L-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100 muM.In contrast, kynurenic acid had no effect. L-Glutamine, glutamic acid, phenylalanine, and methionine produced no appreciable change in NGF synthesis in cultured astroglial cells. None of coumaric acid, caffeic acid, caffeine, chlorogenic acid produced any appreciable change in NGF production in the cells.
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