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Development of immunosuppressant drugs based on inhibition of IL-2 function

Research Project

Project/Area Number 05557022
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SUGAMURA Kazuo  Tohoku University, School of Medicine Professor, 医学部, 教授 (20117360)

Co-Investigator(Kenkyū-buntansha) SATOMI Susumu  Tohoku University, School of Medicine Professor, 医学部, 教授 (00154120)
SASAKI Takeshi  Tohoku University, School of Medicine Professor, 医学部, 教授 (50110656)
ASAO Hironobu  Tohoku University, School of Medicine, 医学部, 助手 (80250744)
仁木 賢  東北大学, 加齢医学研究所, 助手 (60241626)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 1995: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1994: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1993: ¥7,500,000 (Direct Cost: ¥7,500,000)
KeywordsImmune suppression / IL-2 receptor / Monoclonal antibody / Transplantation immunity / 免疫制御 / サイトカイン / γ鎖 / 可溶化型 / IL-2 / 増殖シグナル
Research Abstract

Treatments for tissue transplantation immunity and sutoimmune disease require desirable immunosuppressant drugs which have little side effects. In this study, we have attempted to establish a methodology for suppression of IL-2 function which plays critical roles in immune responses. For this purpose, we firstly demonstrated the subunit structure of functional IL-2 receptors in human and murine. Functional murine IL-2 receptors consist of complexes containing all the three receptor subunits, alpha, beta and gamma chains, while functional human receptors consist of complexes containing all the three receptor subunits or the two subunits, beta and gamma chains. The murine beta and gamma complex has no ability to bind IL-2. The IL-2 receptor gamma chain has also been shown to be shared among receptors for IL-4, IL-7 and IL-9, suggesting that the gamma chain contributes to a variety of functions mediated by these cytokines in vivo.
We have examined effects of anti-alpha, -beta and-gamma chain monoclonal antibodies (mAbs) on skin transplantation mixed lymphocyte reaction in mice. Combination treatment with the three mAbs induced 70% suppression of allo-stimulated mixed lymphocyte reaction, and elongation of transplanted skin tissue suvival times from 3 to 22 days. However, single treatment with each mAb exhibited less effectiveness for such immunosuppression. These results indicated that the mAbs specific for the three subunits of IL-2 receptors have immunosuppressive effects, suggesting a possible development of immunosuppressant drugs using the mAbs.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (88 results)

All Other

All Publications (88 results)

  • [Publications] Asao, H.: "Reconstitution of the functional IL-2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways." Proc. Natl. Acad. Sci. USA. 90. 4127-4131 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, N.: "A novel human tyrosine kinase gene inducible in T cells by interleukin 2." FEBS Lett.324. 1-5 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumaki, S.: "Cloning of the mouse interleukin 2 receptor γ chain: Demonstration of functional differences between the mouse and human receptors." Bioch. Bioph. Res. Comm.193. 356-363 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, M.: "Kinetic study of IL-2 binding on the receonstituted IL-2 recepter complexes including the human γ chain." Eur. J. Immunol.23. 2472-2476 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M.: "Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4." Science. 262. 1874-1877 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakamura, M.: "Interleukin 2 receptor heterotrimer complex and intracellular signaling." Seminars in immunology. 5. 309-317 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asao, H.: "Structure and function of the heterotrimer subunit complex of IL-2 receptor: Implication of the γ chain in signal transduction." “Horizon in Cytokine Research" F. Takaku ed., Mochida Memorial Foundation for Medical and Pharmaceutical Research. 33-44 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M.: "Functional participation of the IL-2 receptor γ chain in IL-7 receptor complexes." Science. 263. 1453-1454 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N.: "Impairment of ligand binding and growth signaling of mutant IL-2 receptor γ chains in patients with X-linked severe combined immunodeficiency." J. Immunol.153. 1310-1317 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, N.: "Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor β and γ chains." Proc. Natl. Acad. Sci. USA. 91. 7271-7275 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N.: "Expression of the interleukin 2 receptor γ chain on various populations in human peripheral blood." Inter. Immunol.6. 1273-1277 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asao, H.: "Interleukin 2-induced activation of JAK3: possible involvement in signal transduction for c-myc induction and cell proliferation." FEBS Letters. 351. 201-206 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M.: "Expression of the mouse interleukin-2 receptor γ chain in various cell populations of thymus and spleen." Eur. J. Immunol.24. 2026-2030 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hozumi, K.: "Implication of the common γ chain of the IL-7 receptor in intrathymic development of pro-T cells." Inter. Immunol.6. 1451-1454 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asano, M.: "Interleukin-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor β chain transgeneic mice." J. Immunol.153. 5373-5381 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Minegishi, Y.: "Preferential utilization of immature JH segment and absence of somatic mutation in CDR3 junction of Ig H chain gene in three X-linked severe combined immunodeficiency patients." Inter. Immunol.6. 1709-1715 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N.: "mAb specific for the γ chain of the IL-2 receptor." Leucocyte Typing V. 2. 1867-1868 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, Y.: "Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex." Inter. Immunol.7. 115-120 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohbo, K.: "Functional analysis of the human interleukin 2 receptor γ chain gene promoter." J. Biol. Chem.270. 7479-7486 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugamura, K.: "The common γ chain for multiple cytokine receptors." Adv. Immunol.59. 225-277 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumaki, S.: "Characterization of B cell lines established from two X-linked severe combined immunodificiency patients: interleukin-15 binds to the B cells but not internalized efficiently." Blood. 86. 1428-1436 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nemoto, T.: "Difference in interleukin 2 (IL-2) receptor system between human and mouse: essential requirement of the α chain for formation of the functional mouse IL-2 receptor." Eur. J. Immunol.25. 3001-3005 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugamura, K.: "The interleukin 2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID." Annu. Rev. Immunol.14. 179-205 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohbo, K.: "Modulation of hematopoiesis in mouse with a truncated mutant of the interleukin-2 receptor γ chain." Blood. 87. 956-967 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saito, S.: "Expression of the interleukin-2 receptor (IL-2R) γ chain on cord blood mononuclear cells." Blood. (in press.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asao, H., Takeshita, T., Ishii, N., Kumaki, S., Nakamura, M., and Sugamura, K: "Reconstitution of the functional IL-2 receptor complexes on fibroblastoid cells : Involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways." Proc. Natl. Acad. Sci. USA. 90. 4127-4131 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, N., Asao, H., Ohtani, K., Nakamura, M., and Sugamura, K: "A novel human tyrosine kinase gene inducible in T cells by interleukin 2." FEBS Lett. 324. 1-5 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumaki, S., Kondou, M., Takeshita, T., Asano, H., Nakamura, M., and Sugamura, K: "Cloning of the mouse interleukin 2 receptor gamma chain : Demonstration of functional differences between the mouse and human receptors." Bioch. Bioph. Res. Comm. 193. 356-363 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, M., Takeshita, T., Ishii, N., Nakamura, M., and Sugamura, K: "Kinetic study of IL-2 binding on the receonstituted IL-2 receptor complexes including the human gamma chain." Eur. J.Immunol. 23. 2472-2476 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M., Takeshita, T., Ishii, N., Nakamura, M., Watanabe, S., Arai, K.and Sugamura, K: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science, 262,1874-1877,1993" Science. 262. 1874-1877 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakamura, M., Asao, H., Takeshita, T.and Sugamura, K: "Interleukin 2 receptor heterotrimer complex and intracellular signaling" Seminars in immunology. 5. 309-317 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asao, H., Kondo, M., Ishii, N., Takeshita, T., Nakamura, M.and Sugamura, K: "Structure and function of the heterotrimer subunit complex of IL-2 receptor : Implication of the gamma chain in signal transduction." Horizon in Cytokine Research F.Takaku ed. Mochida Memorial Foundation for Medical and Pharmaceutical Research. 33-34 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S.and Sugamura, K: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes" Science. 263. 1453-1454 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N., Asao, H., Kimura, Y., Takeshita, T., Nakamaura, M., Tsuchiya, S., Konno, T., Maeda, M., Uchiyama, T.and Sugamura, K: "Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma chains in patients with X-linked severe combined immunodeficiency" J.Immunol. 153. 1310-1317 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, N., Asao, H., Ohbo, K., Ishii, N., Takeshita, T., Nakamaura, M.and Sugamura, K: "Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains." Proc. Natl. Acad. Sci. USA. 91. 7271-7275 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N., Takeshita, T., Kimura, Y., Tada, K., Kondo, M., Nakamura, M.and Sugamura, K: "Expression of the interleukin 2 receptor gamma chain on various populations in human peripheral blood" Inter. Immunol. 6. 1273-1277 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asao, H., Tanaka, N., Ishii, N., Higuchi, M., Takeshita, T., Nakamura, M., Shirasawa, T., and Sugamura, K: "Interleukin 2-induced activation of JAK3 : possible involvement in signal transduction for c-myc induction and cell proliferation" FEBS Letters. 351. 201-206 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kondo, M., Ohashi, Y., Tada, K., Nakamura, M.and Sugamura, K: "Expression of the mouse interleukin-2 receptor gamma chain in various cell populations of thymus and spleen." Eur. J.Jmmunol. 24. 2026-2030 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hozumi, K., Kondo, M., Nozawa, H., Kobori, A., Nishimura, T., Nishikawa, S., Sugamura, K.and Habu, S: "Implication of the common gamma chain of the IL-7 receptor in intrathymic development of pro-T cells" 6. 1451-1454 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asano, M., Ishida, Y., Sabe, H., Kondo, M., Sugamura, K.and Honjo, T: "Interleukin-2 can support growth of CD8+T cells but not CD4+T cells of human IL-2 receptor beta chain transgeneic mice." J.Immunol. 153. 5373-5381 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Minegishi, Y., Okawa, H., Sugamura, K.and Yata, J: "Preferential utilization of immature JH segment and absence of somatic mutation in CDR3 junction of Ig H chain gene in three X-linked severe combined immunodeficiency patients." Inter. Immunol. 6. 1709-1715 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii, N., Kodo, K., Takeshita, T.and Sugamura, K: "mAb specific for the gamma chain of the IL-2 receptor" Leucocyte Typing. V,2. 1867-1868 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, Y., Takeshita, T., Kondo, M., Ishii, N., Nakamura, M., Snick, J.V.and Sugamura, K: "Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex" Inter. Immunol. 7. 115-120 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohbo, K., Takasawa, N., Ishii, N., Tanaka, N., Nakamura, M.and Sugamura, K: "Functional analysis of the human interleukin 2 receptor gamma chain gene promoter." J.Biol. Chem. 270. 7479-7486 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Nakamura, M., and Takeshita, T: "The common gamma chain for multiple cytokine receptors" Adv. Immunol. 59. 225-277 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumaki, S., Ochs, H.D., Timour, M., Schooley, K., Agdieh, M., Hill, H., Sugamura, K., Anderson, D., Zhu, Q., Cosman, D.and Giri, G.J: "Characterization of B cell lines established from two X-linked severe combined immunodificiency patients : interleukin-15 binds to the B cells but not internaized efficiently" Blood. 86. 1428-1436 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nemoto, T., Takeshita, T., Ishii, N., Kondo, M., Higuchi, M., Satomi, S., Nakamura, M., Mori, S.and Sugamura, K: "Difference in interleukin 2 (IL-2) receptor system between human and mouse : essential requirement of the alpha chain for formation of the functional mouse IL-2 receptor" Eur. J.Immunol. 25. 3001-3005 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M.and Takeshita, T: "The interleukin 2 receptor gamma chain : its role in the multiple cytokine receptor complexes and T cell development in XSCID" Annu. Rev. Immunol. 14. 179-205 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohbo, K., Suda, T., Hashiyama, M., Mantani, A., Ikebe, M., Miyakawa, K., Moriyama, M., Nakamura, M., Katsuki, M., Takahashi, K., Yamamura, K.and Sugamura, K: "Modulation of hematopoiesis in mouse with a truncated mutant of the interleukin-2 receptor gamma chain" Blood. 87. 956-967 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saito, S., Morii, T., Umekage, H., Makita, K., Nishikawa, K., Narita, N., Ichijo, M., Morikawa, H., Ishii, N., Nakamura, M.and Sugamura, K: "Expression of the interleukin-2 receptor (IL-2R) gamma chain on cord blood mononuclear cells." Blood. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ishii,N.: "mAb specific for the γ chain of the IL-2 receptor." Leucocyte Typing V. 2. 1867-1868 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kimura,Y.: "Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex." Inter.Immunol.7. 115-120 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,S.: "Involvement of the IL-2 receptor γ subunit in IL-4-dependent activation of mouse hematopoietic cells and splenic B cells." Eur.J.Immunol.25. 126-131 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohbo,K.: "Functional analysis of the human interleukin 2 receptor γ chain gene promoter." J.Biol.Chem.270. 7479-7486 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugamura,K.: "The common γ chain for multiple cytokine receptors." Adv.Immunol.59. 225-277 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Moreau,J.L.: "Control by interleukin-2 and interleukin-4 of the IL-2 responsiveness of murine B cells." J.Immunol.155. 3401-3408 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kumaki,S.: "Characterization of B cell lines established from two X-linked severe combined immunodificiency patients:interleukin-15 binds to the B cells but not internalized efficiently." Blood. 86. 1428-1436 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nemoto,T.: "Difference in interleukin 2(IL-2)receptor system between human and mouse:essential requirement of the α chain for formation of the functional mouse IL-2 receptor." Eur.J.Immunol.25. 3001-3005 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Clark,C.J.P.: "Interleukin 4 inhibits κ light chain expression and NFκB activation but not IkBa degradation in 70Z/3 murine pre-B cells." Eur.J.Immunol. 25. 2961-2966 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Edelbaum,D.,: "Interleukin(IL)-15 promotes the growth of murine epidermal γδ T cells by a mechanism involving the β-and γc-chains of the IL-2 receptor." J.Invest.Dermatol.105. 837-843 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohbo,K.: "Modulation of hematopoiesis in mouse with a truncated mutant of the interleukin-2 receptor γ chain." Blood. 87. 956-967 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugamura,K.: "The interleukin 2 receptor γ chain:its role in the multiple cytokine receptor complexes and T cell development in XSCID." Annu.Rev.Immunol.14. 179-205 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Saito,S.: "Expression of the interleukin-2 receptor (IL-2R)γ chain on cord blood mononuclear cells." Blood. (in press.).

    • Related Report
      1995 Annual Research Report
  • [Publications] Schnyder,B.: "IL-4 and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common γ chain(γc)." Blood. (in press.).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohbo,K.: "Demonstration of a crosstalk between IL-2 and IL-5 in phosphorylation of IL-2 and IL-5 receptor β chains." Inter.Immunol.(in press.).

    • Related Report
      1995 Annual Research Report
  • [Publications] Kondo,M.: "Functional participation of the IL-2 receptor γ chain in IL-7 receptor complexes." Science. 263. 1453-1454 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Roessler,E.: "Cooperative interactions between the interleukin 2 recepotr α and β chains alter the interleukin 2-binding affinity of the receptor subunits." Proc.Natl.Acad.Sci USA. 91. 3344-3347 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Vanham,G.: "The interleukin-2 receptor subunit expression and function on peripheral blood lymphocytes from HIV-infected and control persons." Clin.Immunol Immunopathol.71. 60-68 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ishii,N.: "Impairment of ligand binding and growth signaling of mutant IL-2 receptor γ chains in patients with X-linked severe combined immunodeficiency." J.Immunol.153. 1310-1317 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tanaka,N.: "Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor β and γ chains." Proc.Natl.Acad.Sci.USA. 91. 7271-7275 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ishii,N.: "Expressin of the interleukin 2 receptor γ chain on various populations in human peripheral blood." Inter.Immunol.6. 1273-1277 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Asao,H.: "Interleukin 2-induced activation of JAK3:possible involvement in signal transduction for c-mycinduction and cell proliferation." FEBS Letters. 351. 201-206 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kondo,M.: "Expression of the mouse interleukin-2 receptor γ chain in various cell populations of thymus and spleen." Eur.J.Immunol.24. 2026-2030 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hozumi,K.: "Implication of the common γ chain of the IL-7 receptor in intrathymic development of pro-T cells." Inter.Immunol.6. 1451-1454 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yaegashi,N.: "The frequency of human parvovirus B19 infection in nonimmune hydrops fatalis." J.Perinatal Medicine.22. 159-163 (1994)

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      1994 Annual Research Report
  • [Publications] Asano,M.: "Interleukin-2can support growth of CD8+T cells but not CD4+T cells of human IL-2 receptor β chain transgeneic mice." J.Immunol.153. 5373-5381 (1994)

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      1994 Annual Research Report
  • [Publications] Bosco,M.C.: "Regulation by interleukin-2(IL-2)and interferon γ of of IL-2 receptor γ chain gene expression in human monocytes." Blood. 83. 2995-3002 (1994)

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      1994 Annual Research Report
  • [Publications] Minegishi,Y.: "Preferential utilization of immature JH segment and absence of somatic mutation in CDR3 junction of Ig H chain gene in three X-Iinked severe combined immunodeficiency patients." Inter.Immunol.in press.

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      1994 Annual Research Report
  • [Publications] Kimura,Y.: "Sharing of the IL-2 receptor γ chain with the functionall IL-9 receptor complex." Inter.Immunol.,in press.

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      1994 Annual Research Report
  • [Publications] Watanabe,S.: "Involvement of the IL-2 receptor γ sudunit in IL-4 dependent activation of mouse hematopoietic cells and splenic B cells." Eur.J.Immunol.in press.

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      1994 Annual Research Report
  • [Publications] Ohbo,K.: "Functional analysis for the human interleukin 2 receptor γ chain gene promoter." J,Biol.Chem.in press.

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      1994 Annual Research Report
  • [Publications] Sugamura,K.: "The common γ chain of multiple cytokine receptors." Adv.Immunol.in press.

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      1994 Annual Research Report
  • [Publications] Asao,H.: "Reconstitution of the functional IL-2 receptor complexes on fibroblastoid cells:Involvement of the cytoplasmic domain of the α chain in two distinct signaling pathways." Proc.Natl.Acad.Sci.USA. 90. 4127-4131 (1993)

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      1993 Annual Research Report
  • [Publications] Tanaka,N.: "A novel human tyrosine kinase gene inducible in T cells by interleukin 2." FEBS Lett.324. 1-5 (1993)

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      1993 Annual Research Report
  • [Publications] Kumaki,S.: "Cloning of the mouse interlekin 2 receptor α chain:Demonstration of functional differences between the mouse and human receptor." Bioch.Bioph.Res.Comm.193. 356-363 (1993)

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      1993 Annual Research Report
  • [Publications] Matsuoka,M.: "Kinetic study of IL-2 binding on the receonstituted IL-2 receptor complexes including the human α chain." Eur.J.Immunol.23. 2472-2476 (1993)

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      1993 Annual Research Report
  • [Publications] Nakamura,M.: "Interleukin 2 receptor heterotrimer complex and intracellular signaling." Seminars in Immunology. 5. 309-317 (1993)

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      1993 Annual Research Report
  • [Publications] Kondo,M.: "Sharing of the interleukin-2(IL-2)receptor α chain between receptors for IL-2 and IL-4." Science. 262. 1874-1877 (1993)

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      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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