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新生児脳内の近赤外領域拡散スペクトルの研究

Research Project

Project/Area Number 05557055
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa Medical School

Principal Investigator

ONISHI Shoju  Kagawa Medical School Professor, 医学部, 教授 (40080014)

Co-Investigator(Kenkyū-buntansha) HIRAO Konomu  Otsuka Electronics Researcher, 研究開発1部光散乱グループ, 研究員
KUSAKA Takashi  Kagawa Medical School Instructor, 医学部附属病院, 助手 (50274288)
IMAI Tadashi  Kagawa Medical School Instructor, 医学部, 助手 (60176477)
ISOBE Kenichi  Kagawa Medical School Assistant Professor, 医学部附属病院, 講師 (00159815)
ITOH Susumu  Kagawa Medical School Assistant Professor, 医学部, 講師 (80145052)
澤村 義巳  大塚電子(株), 分光計測グループ, 研究員
岡 宏一  大塚電子(株), 研究開発部, 部長
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥9,500,000 (Direct Cost: ¥9,500,000)
Keywordscontinuous near infrared spectroscopy / diffusion spectra / multi-point method / cerebral Hb oxygen saturation / redox state of cytochrome c oxidase / neonate / premature infant / apne / HbO_2 / cytochrome c oxidase / 脳酸素飽和 / 多プロット化 / 差スペクトル / cytochrome coxidase / 吸収スペクトル平坦化
Research Abstract

In order to prevent and manage hypoxic-ischemic encephalopathy in neonates, it is very important to determine the oxygenated state of Hb, oxygen saturation (SbO_2), the redox state of cytochrome c oxidase, and cerebral blood volume in the cerebral tissue correctly and at real time. Using continuous near infrared spectroscopy (cNIRS) with multi-point method, we converted both the flattened and nonlinear diffusion spectra to both the non flattened and linear spectra and normalized different light pathlengths between respective spectra. Upon calculation of molar ratios of individual chromophore components existing in the light path of a given biological material, it was feasible to determine oxyhemoglobin, deoxyhemoglobin, SbO_2, and the redox state of cytochrome c oxidase in the cerebral tissue in vivo.
Comparing the results measured on the scalp with the result measured directly on the dura of the piglets, a close agreement was proven to exist between the results of indirect and direct measurements. We studied the oxygenation of hemoglobin and the redox state of cytochrome c oxidase in full term and premature infants. SbO_2 was 60-70% in normal term infants and 50-75% in premature infants. The asphyxiated infant had a significantly higher total Hb and SbO_2 than the normal neonates controls. In apneic spell, the oxidized form of cytochrome c oxidase decreased after SbO_2.
Thus, this study demonstrates that continuous bedside monitoring of cerebral hemoglobin oxygenation and the redox state of cytochrome c oxidase might become a useful index for evaluating cerebral hemodynamics and energy state.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Shoju Onishi: "Application of an innovative equation to near infrared spectroscopy analysis which converts the flattened and nonlinear diffusion spectrum of chromophores in the biological tissue to the transmission spectrum" Photomed Photobiol. 15. 57-60 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe: "Clinical application of continuous near infrared spectroscopy-Measurements of the oxygenated state of hemoglobin the redox state of cytochrome c oxidase in the cerebral tissue of newborn piglets before,during and after apnea loading" Photomed Photobiol. 15. 61-64 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takashi Kusaka: "A Basic investigation for clinical application of continuous hear infrared spectroscopy-Determination of the oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in the cerebral tissue of newborn piglets before and after hypoxic loading" Photomed Photobiol. 16. 59-61 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe: "Cerebral oxygen saturation measured by continuous NIR spectroscopy relating to oxygen saturation and oxygen partial of blood in the internal jugular vein and artery" Photomed Photobiol. 16. 55-57 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takashi Kusaka: "Study of oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in cerebral tissue under insulin-induced hypoglycemia using continuous near infrared spectroscopy" Photomed Photobiol. 17. 63-65 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe: "Clinical application of continuous near infrared spectroscopy-cerebral tissue oxygenation status of a severely asphyxiated infant-" Photomed Photobiol. 17. 67- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shoju Onishi, Susumu Itoh, Tadashi Imai, Masanori Nanba, Tetsuya Kunikata, Yoshiki Otaki, Kou Kawada, Kenichi Isobe & Konomu Hirao: "Application of an innovative equation to near infrared spectroscopy analysis which converts the flattened and nonlinear diffusion spectrum of chromophores in the biological tissue to the transmission spectrum" Photomed Photobiol. 15. 57-60 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe, Tadashi Imai, Shoju Onishi, Ryo Fukuzaki, Mayumi Kondo, Masaki Hashimoto, Hitoshi Okada, Yoshiyasu Yaguchi, Susumu Itoh & Konomu Hirao: "Clinical application of continuous near infrared spectroscopy -Measurements of the oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in the cerebral tissue of newborn piglets before, during and after apnea loading-" Photomed Photobiol. 15. 61-64 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takashi Kusaka, Kenichi Isobe, Shoju Onishi, Masanori Nanba, Satoshi Sugihara, Tomoko Gotani, Hitoshi Okada, Yoshiyasu Yaguchi, Kou Kawada, Saburo Shibazaki, Mayumi Nakajima, Tadashi Imai, Susumu Itoh and Konomu Hirao: "A Basic investigation for clinical application of continuous hear infrared spectroscopy -Determination of the oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in the cerebral tissue of newborn piglets before and after hypoxic loading-" Photomed Photobiol. 16. 59-61 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe, Takashi Kusaka, Shoju Onishi, Tetsuya Kunikata, Masana Ono, Kou Kawada, Satoshi Sugihara, Yoshiki Ohtaki, Tadashi Imai, Susumu Itoh and Konomu Hirao: "Cerebral oxygen saturation measured by continuous NIR spectroscopy relating to oxygen saturation and oxygen partial pressure of blood in the internal jugular vein and artery" Photomed Photobiol. 16. 55-57 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takashi Kusaka, Kenichi Isobe, Kou Kawada, Yoshiro Ishii, Tadashi Imai, Susumu itoh, Shoju Onishi and Konomu Hirao: "Study of oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in cerebral tissue under insulin-induced hypoglycemia using continuous near infrared spectroscopy" Photomed Photobiol. 17. 63-65 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Isobe, Takashi Kusaka, Yoshiyasu Yaguchi, Kou Kawada, Mami Ishii, Tadashi Imai, Susumu Itoh, Shoju Onishi and Konomu Hirao: "Clinical application of continuous near infrared spectroscopy -cerebral tissue oxygenation status of a severely asphyxiated infant-" Photomed Photobiol. 17. 67 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takashi Kusaka: "A basic investigation for clinical application of continuous near infrared spectroscopy-determination of the oxygenated state of hemoglobin and the redox state of cytochrome c oxidase in the cerebral tissue of newborn piglets before and after hypoxic loading-." Photomed.Photobiol.16. 59-61 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kenichi Isobe: "Cerebral oxygen saturation measured by continuous NIR spectroscopy relating to oxygen saturation and oxygen partial pressure of blood in the internal jugular vein and artery." Photomed.Photobiol.16. 55-57 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kenichi Isobe: "Clinical application of continuous near infrared spectroscopy Cerebral tissue oxygenation status of a severely asphyxiated infant." Photomed.Photobiol.17. 67- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 河田 興: "Fluorocarbon血液置換の低酸素新生仔豚における近赤外連続スペクトルとP-MRSの同時測定による脳エネルギー代謝の基礎的検討" 日本未熟児新生児学会雑誌. 8(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 今井 正: "新生児中枢神経障害の診断と管理" 産婦人科治療. 68. 22-23 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 日下 隆: "近赤外線領域の連続スペクトル測定の基礎的検討" 日本未熟児新生児学会雑誌. 6. 107-119 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takashi Kusaka: "A BASIC INVESTIGATION FOR CLINICAL APPLICATION OF CONTINUOUS NEAR INFRARED SPECTROSCOPY" PHOTOMEDICME AND PHOTOBIOLOGY. 16(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shoju Onishi: "APPLICATION OF AN INNOVATIVE EQUATION TO NEAR INFRARED SPECTROSCOPY ANALYSIS WHICH CONVERTS" Photomedicine and Photobiology. 15. 57-60 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kenichi Isobe: "CLINICAL APPLICATION OF CONTINUOUS NEAR INFRARED SPECTROSCOPY" Photomedicine and Photobiology. 15. 61-64 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大西鐘壽: "脳のエネルギー代謝とその障害" 日本未熟児新生児学会雑誌. 5. 77-101 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大西鐘壽: "周生期脳障害の診断と治療 序論" 日本新生児学会雑誌. 30. 195-207 (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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