| Project/Area Number |
05557058
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUNO Seiki School of Medicine, Tohoku University, Professor, 医学部, 教授 (80004737)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATSUKA Katsuto Tohoku University, Sch, of Technology Professor, 工学部, 教授 (60005345)
WATANABE Yutaka Tohoku University, Sch, of Technology Assistant Professor, 工学部, 講師 (10260415)
SHOJI Testuo Tohoku University, Sch, of Technology Professor, 工学部, 教授 (80091700)
SHIBATA Chikashi Tohoku University, Sch, of Medicine Assistant Professor, 医学部, 助手 (30270804)
SASAKI Iwao Tohoku University, Sch, of Medicine Associate Professor, 医学部, 助教授 (60125557)
内藤 広郎 東北大学, 医学部附属病院, 講師 (90180223)
中島 美樹子 東北大学, 工学部・附属破壊力学応用研究施設, 助手 (80005488)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1994: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1993: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | magnetic fluid / gastric empting / 胃排出 |
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| Research Abstract |
It is one of very important factor to analyze the gastrointestinal motility for accurate understanding of pathophysiology in gastrointestinal disease. However, ideal method to measure the gastrointestinal motility clinically has not been established. Only a radioisotope technique has been available as a method to evaluate gastric emptying directly which will be significantly useful for the investigation of gastric disease. But, this method has not been so common in ordinary hospital, and not accepted as a clinical test covered by Japanese health insurance system, because, in radioisotope method, it is not so easy to deal with radioactive subject by legal and facility difficulties, and there is a medical problem of exposure to high level of radioisotope. Therefore, the destination of this project should be to develop a novel technique to measure the gastric emptying accurately without radiation exposure which will propagate world widely. Then, we have paid attention to magnetic fluid fo
… More
r performance of this aim. The principle of our method is to get the data about distributive information of magnetic fluid by measuring magnetic field grandient and magnetic field strength to reconstruct the figure or intensity of ingested magnetic fluid which will be located in the homogenous magnetic condition. Employing this principle, we have tried to establish the measuring system which can observe gastric figure and gastric emptying after evaluation of location and residual intensity of magnetic fluid in the stomach. For this purpose, we have investigated 1)the most suitable magnetic fluid for the clinical use 2)the measuring system and it' development in accuracy. The results were obtained as follows : Magnetic fluid which is consisted with central magnetites and superficial monopalmitic acid polyoxyethylenesorbitan was clarified as the most suitable for clinical use of ingestion, because it has no toxicity to human and is neither absorbable nor cohesive in the gastrointestinal lumen. The measuring system has been recently evolved both in the duration and accuracy by changing the Hall element to the new element conceived according to flux principle low. Then it has been possible to detect fine figure of gastric outline, and quantitative evaluation of gastric emptying was also able to be evaluated according to the evidence of good correlation between the calculated values and measured values of concentration of magnetic fluid and magnetic field density in model stomach. These results obtained in this project study showed the positive possibility of this novel method for clinical application. Less
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